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International Journal of Phytomedicine and Phytotherapy

Fig. 1 | Clinical Phytoscience

Fig. 1

From: Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity

Fig. 1

Photomicrograph of the liver Fig. (I-IV) and kidney Fig. (V-VII) of wistar albino rat under various experimental treatments. I- liver photomicrograph of rats fed with normal feed and distilled water only: Normal histomorphology of the hepatic tissue, distinct hepatocyte nuclei correctly located in the cytosol (black arrows). No noticeable histopathological distortion in the liver tissues. II- liver photomicrograph of rats administered with 3 ml/kg bw CCl4 only: Distorted liver histoarchitecture (black arrows) with noticeable fatty liver (broken circles). III- liver photomicrograph of rats exposed to 3 ml/kg bw CCl4 and treated with 100 mg/kg S. acuta: Liver histoarchitecture was normal. No noticeable histopathological distortion was found in the hepatic tissues. IV - liver photomicrograph of rats exposed to 3 ml/kg bw CCl4 and treated with 100 mg/kg bw Silymarin: Distinctly stained and well positioned hepatocytic nuclei was observed. No histopathological distortion of the liver histoarchitecture. V - kidney photomicrograph of rats administered with distilled water only: Cellular delineation, distribution density and staining were appropriate. No apparent histopathological distortion was observed. VI - kidney photomicrograph of rats administered with 250 mg/kg bw rifampicin only: Marked distortion in renal histoarchitecture coupled with glomerular atrophy. Tubular degeneration, formation of pathological cast, intraluminal exfoliation and observable pyknosis of the nuclei were noticeable. VII- kidney photomicrograph of rats administered with 250 mg/kg bw rifampicin and treated with 100 mg/kg bw of S. acuta: Normal renal corpuscle with typical cellular delineation, distribution, density and staining intensity. No apparent histopathological alteration. CT - Convoluted tubule, GC- glomerular capillaries, P- podocytes, JC- juxtaglomerular cells MD- macula densa cells

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