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International Journal of Phytomedicine and Phytotherapy

Table 3 Sub-chronic toxicity study from the plasma using AST, ALT, Total protein, bilirubin, albumin, ALP, creatinine, urea and uric acid in male and female rats treated at 2.5 mg/kg and 5 mg/kg dose of Mystomate4® compared with control administered the vehicle

From: Acute and sub-chronic toxicity assessment and evaluation of the gastro-protective activity of polyherbal formulation “Mystomate4® against gastric ulcer in experimental laboratory animal

Group

Control

HM-5 mg/kg

HF-5 mg/kg

LM-2.5 mg/kg

LF-2.5 mg/kg

AST(U/L)

308.10 ± 2.11

298.14 ± 8.06

307.62 ± 20.14

318.32 ± 11.17

270.12 ± 8.06

ALT (U/L)

60.12 ± 1.22

71.22 ± 2.12*

86.53 ± 7.25*

70.56 ± 2.28*

56.25 ± 2.23

Total protein (g/dL)

76.56 ± 4.01

69.87 ± 4.50

74.12 ± 2.52

67.10 ± 4.37

76.30 ± 1.52

Total Bilirubin (umol/L)

2.37 ± 0.22

2.12 ± 0.76

1.75 ± 0.24

1.65 ± 0.12*

1.63 ± 0.31*

Albumin (g/L)

38.15 ± 5.10

43.84 ± 3.25

44.12 ± 1.20

38.22 ± 4.22

46.53 ± 2.45*

Alkaline phosphatase (ALP) (U/L)

160.23 ± 42.12

250.53 ± 8.24*

155.25 ± 10.12

192.25 ± 45.54

175.56 ± 15.25

Creatinine (umol/L

69.22 ± 4.21

66.20 ± 1.25

57.35 ± 5.21*

68.67 ± 8.52

61.22 ± 1.24*

Urea (umol/L)

5.98 ± 1.10

1.24 ± 1.46*

4.54 ± 1.52

4.56 ± 1.21*

4.87 ± 0.82

Uric acid (mmol/L

122.14 ± 2.40

110.58 ± 1.20

140.25 ± 20.54

116.34 ± 18.24

102.01 ± 5.54

Blood Urea: Creatinine

0.086 ± 0.001

0.019 ± 0.000*

0.079 ± 0.001*

0.066 ± 0.000*

0.080 ± 0.002*

  1. CN Control, HM 5 g/kg male, HF 5 g/kg female, LM 2.5 g/kg male and LF = 2.5 g/kg female. n = 8 rats per group. Statistical comparison was determined by one way ANOVA followed by Tukey’s multiple comparison tests. *P ≤ 0.05, statistically significant compared to control