Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Design, treatment and follow-up schedule of pooled studies

	Bach study [16]	GRANU study [17]
General design	Multicenter, randomized, double-blind, placebo-controlled	Multicenter, randomized, partially blind^a, placebo-controlled
Conduction period	1996-1998	2005-2009
No. of sites	65 urology practices	158 urology practices
Country	Germany	Germany
Indication	LUTS/BPH	LUTS/BPH
Efficacy variable	IPSS	IPSS
Study medications	PSE Placebo	PSE Placebo Pumpkin seeds^a
Run-in period	1 month (placebo)^b	1 month (no treatment)
Treatment period	12 months	12 months
Follow-up visits	After 1, 3, 6, 9, 12 months	After 3, 6, 9, 12 months

PSE pumpkin seed soft extract
^aOpen administration of Uromedic® pumpkin seeds; data ignored for the meta-analysis
^bPatients with change in IPSS ≥3 points during the run-in period were excluded from randomization