Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Responders after 12 months of treatment and differences between treatments

Analysis set Study		No. of patients Total/Responders	Responder %	Difference^a % [95% CI]	P value
ITT
Bach study	Total	465 / 276	59
	PSE	227 / 147	65
	Placebo	238 / 129	54	11 [1, 20]	0.02
GRANU study	Total	924 / 447	48
	PSE	460 / 221	48
	Placebo	464 / 226	49	-1 [−7, 6]	0.84
Pooled	Total	1389 /723	52
	PSE	687 / 368	54
	Placebo	702 / 355	51	3 [−2, 8]	0.28
PP
Bach study	Total	356 / 223	63
	PSE	178 / 120	67
	Placebo	178 / 103	58	10 [−1, 20]	0.08
GRANU study	Total	579 / 295	51
	PSE	290 / 151	52
	Placebo	289 / 144	50	2 [−6, 11]	0.62
Pooled	Total	935 / 518	55
	PSE	468 / 271	58
	Placebo	467 / 247	53	5 [−2, 12]	0.13

ITT set (using LOCF) and PP set (as observed). PSE pumpkin seed soft extract
^aDifference means the percentage of PSE responders minus the percentage of placebo responders