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International Journal of Phytomedicine and Phytotherapy

Table 7 Statistical characteristics of changes from baseline to 12 months for urologic parameters (ITT set)

From: Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months

Variable

 Study

PSE

Placebo

 

n

Mean (SD)

Median [min/max]

n

Mean (SD)

Median [min/max]

P value

Maximum urinary flow rate, Qmax (mL/s)

Bach study

205

3.9 (7.3)

2.5 [−8/45]

207

3.3 (7.3)

1.9 [− 10/38]

 

GRANU study

404

3.6 (6.3)

2.6 [−14/34]

405

3.6 (6.4)

2.0 [−11/42]

 

Pooled

609

3.7 (6.7)

2.5 [−14/45]

612

3.5 (6.7)

2.0 [−11/42]

0.55

Post-void residual volume, PVR (mL)

Bach study

207

−12.2 (45.4)

− 10.0 [− 249/150]

214

−17.2 (41.1)

− 10.0 [− 164/120]

 

GRANU study

421

− 1,8 (41.2)

0.0 [− 23/283]

420

1.2 (41.1)

0.0 [− 20/232]

 

Pooled

626

−5.3 (42.9)

− 0.5 [− 249/383]

634

− 5.0 (42.0)

− 3,1 [− 164/232]

0.90

Prostate volume, PV (mL)

Bach study$

118

− 1.7 (15.1)

−0.3 [− 50/70]

111

−4.0 (17.7)

− 2.0 [− 123/42]

 

GRANU study

421

2.4 (9.8)

1.0 [− 30/55]

419

2.6 (10.2)

2.0 [− 22/77]

 

Pooled

539

1.5 (11.3)

1.0 [− 50/70]

530

1.2 (12.4)

1.0 [−123/77]

0.67

  1. aProstate volume measurement was optional. PSE pumpkin seed soft extract