Fig. 3
From: Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction
Effect of treatment on the expression of cardiac PI3K/AKT downstream genes and apoptosis in the studied groups. A PI3K gene expression, B AKT gene expression, C FOXO-1 gene expression, D eNOS gene expression. Data are presented as mean ± SD, significance was set at P < 0.05, n = 6. a: Significant versus normal control group. b: Significant versus ISO group. c: Significant versus LY294002 + ISO group. e: significant versus DATS+ISO group. PI3K: Phosphatidylinositide 3-Kinases. Akt: Serine and Threonine Kinase. FOXO-1: Forkhead Box Protein O-1. eNOS: Endothelial Nitric Oxide Synthase. ISO: Isoproterenol induced AMI group (85 mg/kg isoproterenol), LY294002 + ISO: PI3K inhibitor group (0.3 mg/kg), DATS+ISO: Diallyl trisulfide pretreated group (40 mg/kg), CAP+ISO: Captopril pretreated group (50 mg/kg), DATS+LY294002 + ISO: Diallyl trisulfide and PI3K inhibitor pretreated group, CAP+LY294002 + ISO: Captopril and PI3K inhibitor pretreated group