Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of treatment on cardiac histopathological scoring of necrosis and inflammation in the studied groups

Group	Normal Control	ISO	LY294002 + ISO	DATS + ISO	CAP + ISO	DATS + ISO + LY294002	CAP + ISO+ LY294002
Necrosis	0 ± 0	11.28 ± 1.13 ^a	10.4 ± 0.47 ^a	5.8 ± 0.78 ^a,b,c	6.56 ± 0.86 ^a,b,c	9.76 ± 0.99 ^a,b	10.02 ± 1.14 ^a,b
Inflammation	0 ± 0	18.56 ± 2.11 ^a,c	14.72 ± 1.32 ^a,b	8.18 ± 1.04 ^a,b,c	8.44 ± 1.2 ^a,b,c	11.56 ± 1.09 ^a,b,c	12.82 ± 2.1 ^a,b,c

Data are presented as mean ± SD, significance was set at P < 0.05, n = 6. ISO: Isoproterenol induced AMI group (85 mg/kg/d), LY294002 + ISO: PI3K inhibitor group (0.3 mg/kg/d), DATS+ISO: Diallyl trisulfide pretreated group (40 mg/kg d), CAP+ISO: Captopril pretreated group (50 mg/kg/d), DATS+LY294002 + ISO: Diallyl trisulfide and PI3K inhibitor pretreated group, CAP+LY294002 + ISO: Captopril and PI3K inhibitor pretreated group. a: Significant versus normal control group. b: Significant versus ISO group. c: Significant versus LY294002 + ISO group