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Table 7 Effect of MECM on carrageenan-induced paw edema inhibition

From: Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model

Treatment (mg/kg)

Pre-injection mean paw circumference (mm)

Post-injection mean paw circumference (mm) (% inhibition)

1 hour

2 hour

3 hour

4 hour

Control-Tween 80 solution (10 ml/kg)

9.80 ± 0.58

14.60 ± 0.51

-

15.20 ± 0.49

-

14.80 ± 0.37

-

14.20 ± 0.49

-

Standard-Indomethacin (10 mg/kg)

10.20 ± 0.37

13.50 ± 0.35

(31.25%)

13.00 ± 0.35

48.15%

11.20 ± 0.41**

(76%)

10.80 ± 0.44**

(86.36%)

MECM 200 mg/kg

9.60 ± 0.51

13.90 ± 0.33

(10.41%)

13.40 ± 0.33

(29.63%)

12.40 ± 0.29**

(44%)

11.70 ± 0.30**

(52.27%)

MECM 400 mg/kg

9.30 ± 0.37

13.30 ± 0.37

(16.67%)

12.80 ± 0.37

35.19%

11.70 ± 0.44**

(52%)

11.20 ± 0.34**

(56.82%)

  1. MECM Methanolic extract of seeds, SEM Standard error of the mean
  2. All values are expressed as Mean ± SEM (N = 5)
  3. **p < 0.01, ***p < 0.001 were considered statistically significant compared to control
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