International Journal of Phytomedicine and Phytotherapy
From: African natural products with potential antioxidants and hepatoprotectives properties: a review
Plants | Family | Part used | Solvents | Toxicant | Dose of extract (mg/kg) | Ameliorative effect demonstrated by the extract on toxin induced alterations in biomarkers of liver integrity | Country of origine | References |
---|---|---|---|---|---|---|---|---|
Acalypha racemosa H.M. | Euphorbiaceae | Leaf | H2O | CCL4 | 60 | Decrease serum AST, ALT, and total bilirubin and increase serum TP and ALB concentrations | Nigeria | [312] |
Acalypha wilkesiana L. | Euphorbiaceae | Leaf | H2O | PCM | 100/200/300 | Decrease serum AST, ALT and ALP activities and prevent histopathological alterations in liver | Nigeria | [313] |
Aframomum melegueta K. Schum. | Zingiberaceae | Fruit | H2O | EtOH | 100 | Decrease serum AST, ALT and TG. Increase serum SOD GSH and prevent histopathological alterations in liver | Nigeria | [314] |
Ajuga iva (L.) | Lamiacea | Aerial parts | Oil | CCL4 | 50 | Decreas serum ALP,AST, ALT | Libya | [315] |
Alchornea cordifolia Mull. Arg. | Euphorbiaceae | Leaf | MeOH | CCL4 | 300 | Decrease serum AST, ALT, ALP and TB | Nigeria | [147] |
Allanblackia gabonensis (Pellegr.) Bamps. | Guttiferae | Stem bark | H2O | PCM | 100/200 | Decrease serum ALT, AST, bilirubin and MDA, increase SOD, CAT and GSH | Cameroon | [111] |
Anacardium occidentale L. | Anacardiaceae | Leaf | MeOH | CCL4 | 500/1000 | Decrease serum AST, ALT and ALP | Nigeria | [316] |
Andrographis paniculata Bum.F. | Acanthaceae | Leaf | H2O | CCL4 | 100–300 | Decrease serum AST, ALT, ALP, TB,DBL,CHL, TG, LDL, VLDL and MDA | Nigeria | [317] |
Annona muricata L. | Annonaceae | Leaf | EtOH | PCM | 400 | Decrease serum AST, ALT, ALP, TP and TB levels. Prevented toxins-induced liver necrosis | Nigeria | [318] |
Azadirachta indica A, Juss. | Meliaceae | Leaf | EtOH | PCM | 300 | Decrease serum AST, ALT, ALP, GGT, CHOL and TG. Prevented toxins induced alterations in haematological parameters | Nigeria | [319] |
Balanites aegyptiaca (L.) Delile. | Balantitiaceae | Stem bark | H2O | PCM | 100 | Decrease serum AST, ALT and ALP activities | Nigeria | [320] |
Camellia sinensis (L.) Kuntze | Theaceae | Leaf | H2O | Tamoxifen | 45 | Decrease serum AST, ALT and TBARS | egypt | [321] |
Carica papaya L. | Caricaceae | Leaf | H2O | PCM and CC14 | 100/300 | Decrease serum AST, ALT, ALP, BIL and MDA. Increase GSH, CAT and SOD | Nigeria | [322] |
Cassia italic Mill. | cesalpiniaceae | Leaf | EtOH | CCL4 | 200 | Decrease serum and liver AST, ALT, ALP and GGT. | Nigeria | [323] |
Cassia Occidentalis L. | Caesalpinoidae | Leaf | H2O | PCM | 250/500 | Prevented vascular congestion, periportal infiltrates of chronic inflammatory cells and periportal oedema. | Nigeria | [324] |
Cassia sieberiana DC. | Fabaceae | Leaf | MeOH | CCL4 | 100/200/400 | Decrease serum AST, ALT, ALP MDA. Increase serum CAT | Nigeria | [163] |
Cassia singueana Burkill. H.M. | Fabaceae | Root | MeOH | CCL4 | 50 | Decrease serum AST, ALT BIL, MDA and LDL Increase serum HDL,SOD, CAT, | Nigeria | [325] |
Chrysophyllum Albidum G. Don. | Sapotaceae | Leaf | EtOH | CCL4 | 500/1000/1500 | Decrease serum AST, ALT, ALP and TB. Prevented toxins-induced centrilobular fat ty degeneration and necrosis in liver | Nigeria | [326] |
Cochlospermum tinctorium A. Rich. | Cochlospermaceae | Leaf | MeOH | CCL4 | 200 | Decrease serum ALT, AST, bilirubin and MDA and prevent histopathological alterations in liver | Nigeria | [72] |
Cochlospermum Tinctorium A. Rich. | Cochlospermaceae | Leaf | MeOH | CCL4 | 200 | Decrease serum AST, ALT, CHOL, MDA and BIL levels. | Nigeria | [72] |
Costus afer L. | Zingiberaceae | Stem | MeOH | ALC | 60/120 | Decrease serum AST, ALP | Nigeria | [327] |
Echinops galalensis Schweinf. | Asteraceae | Aerial parts | MeOH | CCL4 | 100 μg/mL | Decreas AST, ALT, MDA level and increase SOD activities | Egypt | [102] |
Erythrina senegalensis L. | Fabaceae | Stem bark | EtOH | CCL4 | 100 | Decrease serum ALT, AST and lipid peroxidationin liver homogenate | Cameroon | [116] |
Ficus chlamydocarpa Mildbr. & Burret | Moraceae | Stem bark | MeOH | CCL4 | 50–200 | Increase hepatic GSH, decrease liver MDA decrease AST, ALT and LDH | Cameroon | [99] |
Ficus exasperate Vahl. | Moraceae | Leaf | EtOH | PCM | 125/150/500 | Decrease serum AST,ALT,ALP and TB | Nigeria | [115] |
Ficus exasperata Vahl. | Moraceae | Leaf | EtOH | PCM | 125–500 | Increase liver ALT, AST but decrease liver ALP and bilirubin level | Nigeria | [115] |
Gongronema latifolium | Asclepiadaceae, | Leaf | H2O | CCL4 | 500 | Decrease serum AST, ALT, ALP TB,CRT, urea, CHOL andTG | Nigeria | [328] |
Harungana madagascariensis Lam. ex Poiret. | Hypericaceae | Root | H2O | PCM | 100–500 | Decrease serum ALT, AST, ALP and FBG but increase serum levels of TP and ALB | Nigeria | [329] |
Hibiscus cannabinus L. | Malvaceae | Leaf | H2O | PCM/cm3 | 1600 | Decrease serum AST, ALT, BIL and MDA. Prevented toxin induced severe inflamm at ion and liver necrosis | Nigeria | [330] |
Hibiscus sabdariffa L. | Malvaceae | Flower | EtOH | CCL4 | 200/300 | Decrease serum ALT, AST, ALP,TC, LDL-C, TG and liver MDA level. 1ncrease in HDL-C, vitamins A, C, and β-carotene level | Nigeria | [331] |
Hibiscus sabdariffa L. | Malvaceae | Leaf | MeOH | CCL4 | 500/1000 | Decrease serum ALT, AST, ALP, LDH and TBARS but increase serum GSH, SOD and CAT | Nigeria | [177] |
Hibiscus Sabdariffa L. | Malvacea | Leaf | MeOH | CCL4 | 600/1000 | Increase serum SOD, CAT, GSH and decrease serum ALP | Nigeria | [332] |
Irvingia gabonensis | Irvingiaceae | Leaf | EtOH | Sodium arsenite | 250/500 | Decrease serum ALT, AST and γGT and prevent histopathological alterations in liver | Nigeria | [100] |
Khaya grandifoliola C.DC. | Meliaceae | Stem bark | EtOAc/MeOH | CCL4 | 25/100 | Decreas serum ALP,AST, ALT and TP; Increase liver TBARS, SOD,GSH and GR) in liver. | Cameroon | [83] |
Khaya senegalensis (Desr.) A Juss. | Meliaceae | Stem bark | H2O | PCM | 100 | Decrease serum AST, ALT and ALP activities | Nigeria | [320] |
Lawsonia inermis L. | Lythraceae | Leaf | H2O | CCL4 | 100/150 | Decrease serum AST and ALT | Nigeria | [107] |
Lawsonia inermis L. | Lythraceae | Leaf | MeOH | CC14 | 100/200 | Decrease serum AST, ALT, ALP. TP and BIL. Prevented toxin induced necrosis of hepatic architecture with vacuolization and congestion of sinusoids | Sudan | [106] |
Mangifera Indica L. | Anacardiaceae | Stem bark | H2O/EtOH | PCM | 200 | Decrease serum AST, ALT, ALP and MDA increase TP, GSH, CAT and SOD | Nigeria | [333] |
Marrubium vulgare L. | Lamiacea | Aerial parts | Oil | CCL4 | 50 | Decreas serum ALP,AST, ALT | Libya | [315] |
Moringa oleifera L. | Moringaceae | Leaf | EtOH | Alcohol | 300 | Decrease serum AST, ALT, ALP, GGT andprevented histopathological changes in liver. | Nigeria | [63] |
Nauclea latifolia L. | Rubiaceae | Leaf | EtOH | PCM | 400 | Decrease serum AST, ALT, increase serum TP, ALB, CAT,GPx andSOD concentrations | Nigeria | [334] |
Newbouldia Laevies (P. Beauv) Seem. Ex Burea | Bignoniaceae | Leaf | EtOH | CCL4 | 100/300 | Decrease serum AST, ALT,ALP,TB,TP andCHL | Nigeria | [335] |
Ocimum americanum L. | Lamiaceae | Leaf | H2O | PCM | 200/400 | Decrease serum ALP, AST, ALT. TBIL and preserve liver architecture | Nigeria | [94] |
Ocimum gratissimum L. | Lamiaceae | Leaf | H2O | CCL4 | 500 | Decrease serum AST, ALT, ALP TB,CRT, urea, CHOL andTG | Nigeria | [328] |
Prosopis africana (Guill. & Perr.) Taub. | Mimosaceae | Stem bark | H2O | PCM | 100 | Decrease serum AST, ALT and ALP activities | Nigeria | [320] |
Rosmarinus officinalis L. | Lamiacea | Aerial parts | Oil | CCL4 | 50 | Decreas serum ALP,AST, ALT | Libya | [315] |
Senna alata (L.) Roxb. | Fabaceae | Leaf | MeOH | CCL4 | 400 | Decrease serum ALT, AST, ALP, total and direct bilirubin and liver TBARS, increase serum total protein and albumin and prevent histopathological alterations in liver | Nigeria | [68] |
Spathodea campanulata P. Beauv. | Bignoniaceae | Stem bark | H2O | CCL4 | 100/300/625 | Decrease serum AST, ALT and GGT and prevent histopathological alterations in liver | Ghana | [86] |
Sphenocentrum jollyanum L. | Menispermaceae | Stem bark | MeOH | CCL4 | 50/100/200 | Decrease serum AST,ALT, ALP, TB and LP and Increase liver TP, SOD, CAT, GPx GST | S. Africa | [96] |
Swietenia Mahogani (L.) Jacq. | Maliaceae | Leaf | H2O | Alcohol | 250/500 | Decrease serum AST, ALT, ALP BIL and CRT | Nigeria | [336] |
Telfairia occidentalis Hook. F. | Cucurbitaceae | Leaf | EtOH | CCL4 | 500 | Increase livee AST, ALT, ALP and prevented toxin-induced central vein congestion with eroded endothelium and haemolised blood vessels, pkynotic nucleic and fats infiltration | Nigeria | [337] |
Thymus capitatus L. | Lamiacea | Aerial parts | Oil | CCL4 | 50 | Decreas serum ALP,AST, ALT | Libya | [315] |
Tulbaghia violacea Harv. | Alliaceae | Rhizome | − | Atherosclerogenic (ath) | 250/500 | Decrease Serum TG, TC, LDL-C, VLDL-C, TBARS, fibrinogen, LDH, AST,ALT, ALP, BIL,CRET and prevent histopathological alterations in liver | South Africa | [263] |
Uvaria afzelii P. Beauv. | Annonaceae | Root | MeOH | CCL4 | 125/250/500 | Decreases serum ALT, AST, ALP, total and un-conjugated bilirubin | Nigeria | [76] |
Vernonia ambigua L. | Asteraceae | Leaf | EtOH | CCL4 | 250/500 | Decrease serum ALT, AST and ALP, TB, CHOL, TGA increase TP and ALB | Nigeria | [90] |
Vernonia amygdalina Delile. | Asteraceae | Leaf | EtOH | PCM | 300 | Decrease serum AST, ALT, ALP, GGT, CHOL and TG. Prevented toxins induced alterations in haematological parameters | Nigeria | [319] |
Vernonia amygdalina Delile. | Asteraceae | Leaf | MeOH | Â | 20/60 | Increase liver and kidney AST and ALT, | Nigeria | [338] |
Vitellaria paradoxa C.F. Gaertn. | Sapotaceae | Stem bark | H2O | PCM | 100 | Decrease serum AST, ALT and ALP activities | Nigeria | [320] |
Xylopia aethiopica Delile. | Annonaceae | Stem bark | H2O | CCL4 | 250/500 | Decrease serum AST, ALT, ALP and BIL | Nigeria | [339] |
Satureja punctata (Benth.) Briq. | Lamiaceae | Aerial parts | H2O | Fe-NTA | 250/500 | Decrease serum AST, ALT, ALP | Ethiopia | [291] |
Solanecio angulatus (Vahl) C. Jeffrey | Asteraceae | Leaf | H2O | Fe-NTA | 250/500 | Decrease serum AST and ALT, | Ethiopia | [291] |
Cineraria abyssinica Sch. Bip.ex A. | Asteraceae | Leaf | MeOH/H2O | CCL4 | 200 | Decrease serum AST, ALT, ALP. Prevented toxins induced liver necrosis and inflammation | Ethiopia | [340] |