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International Journal of Phytomedicine and Phytotherapy

Table 2 Summary of major classes of drug and the Cytochrome enzyme/transport protein involved during adverse events

From: Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

Drug/class Cytochrome enzyme/transport protein involved Effect of interaction
Digoxin/cardiac glycoside P-gp Decreases drug AUC by 25-30 %
Nifedipine/calcium channel blocker CYP3A4, P-gp Decreases drug AUC by 45 %
Simvastatin/antihyperlipidemic CYP3A4 Decreases drug AUC by 50 %
Warfarin/anticoagulant CYP2C9 Loss of efficacy due to decrease in INR
  1. Adapted from [23]