Articles

Bioactive constituents with antibacterial, resistance modulation, anti-biofilm formation and efflux pump inhibition properties from Aidia genipiflora stem bark

Antimicrobial resistance is a global health challenge. The involvement of bacterial biofilms and efflux pumps in the development of multidrug resistance (MDR) is well established. Medicinal plants have been pr...

Authors: Daniel Anokwah, Evelyn Asante-Kwatia, Abraham Y. Mensah, Cynthia Amaning Danquah, Benjamin K. Harley, Isaac Kingsley Amponsah and Lukas Oberer

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

Persea americana (PA) is a popular medicinal plant in folkloric medicines. The present study therefore investigates the ameliorative potentials of its leaves extract on carbon tetrachloride and rifampicin-induced...

Authors: Temidayo Ogunmoyole, Iretiogo Dada and Oluwatosin Adebukola Adebamigbe

Correction to: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, preventive potential and tolerability of BNO 1030 extract, containing Althea root, Chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

An amendment to this paper has been published and can be accessed via the original article.

Authors: Vasyl Popovych, Ivana Koshel, Oleksandr Malofiichuk, Lubov Pyletska, Oleksandr Semenyuk, Oksana Martynnyk and Ruslana Orlovska

Serotonergic and noradrenergic response of ethanol extract; opioidergic response of ethyl acetate extract of Dicranopteris linearis L. leaf

Dicranopteris linearis L. is among the popular tribal plants used for various ailments, although many of its pharmacological potentials have not been investigated yet. The neuropharmacological potentials of the l...

Authors: Mohammad Mustakim Billah, Ayreen Sonia Chowdhury, Kashfia Nawrin, Saqline Mostaq, Md. Abu Rayhan and Razwanur Rahman Tushar

Phytowaste as nutraceuticals in boosting public health

The utilization of bioactive constituent of peels and seeds provide an effective, environment friendly and inexpensive therapy for different forms of human disease, and the production, improvement and document...

Authors: Chinyere S. Dike, Chinna N. Orish, Chukwuemeka R. Nwokocha, Francis D. Sikoki, Bolaji B. Babatunde, Chiara Frazzoli and Orish E. Orisakwe

Proteolytic enzyme arbitrated antagonization of helminthiasis by Cinnamomum cappara leaf extract in Pheretima posthuma

There have been several studies carried out to irradiate Helminthiasis however very little research have been carried out where in the enzymatic activity of plants are exploited to antagonize infections. Here ...

Authors: Kayeen Vadakkan, Meena K Cheruvathur, Anu S Chulliparambil, Famy Francis and Anu P Abimannue

Benefits of Stryphnodendron adstringens when associated with hydrogel on wound healing in diabetic rats

The plant Stryphnodendron adstringens is a species of legume in the genus Stryphnodendron that is found in Brazil. It is also known as “barbatimão-verdadeiro” and it is popularly used in folk medicine due to its ...

Authors: Patricia de Souza de Aguiar, Áurea Pandolfo Correa, Flavia Tasmin Techera Antunes, Alexandre Falcão de Barros Ferraz, Suele Biehals Vencato, Gabriela Jouglard Vasques Amado, Elenir Wiiland, Dione Silva Corrêa, Ivana Grivicich and Alessandra Hubner de Souza

Alpha lipoic acid attenuated neuropathic pain induced by chronic constriction Injury of sciatic nerve in rats

Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and...

Authors: Prasad Neerati and Harika Prathapagiri

Evaluation of antipsoriatic activity of gel containing Pongamia pinnata extract on Imiquimod-induced psoriasis

Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate...

Authors: Kamlesh Wadher, Shital Dabre, Anjali Gaidhane, Sagar Trivedi and Milind Umekar

Sorghum halepense (L.) Pers rhizomes inhibitory potential against diabetes and free radicals

Owing to the side effects of synthetic medicine and less effectiveness against different syndromes, the researchers have focused on phytotherapy to overcome these problems. The purpose of this project was to s...

Authors: Muhammad Abdur Rehman Shah, Rahmat Ali Khan and Mushtaq Ahmed

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Midd...

Authors: Mohamad Hesam Shahrajabian, Wenli Sun and Qi Cheng

Phytodentistry in Africa: prospects for head and neck cancers

Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Al...

Authors: Henry A. Adeola, Saheed Sabiu, Raphael T. Aruleba, Tayo A. Adekiya, Anthonio O. Adefuye, Ogheneochuko J. Adefuye and Babatunji E. Oyinloye

Efficacy, safety and phytochemistry of medicinal plants used for the management of diabetes mellitus in Ethiopia: a systematic review

Despite tremendous developments in synthetic medicine, medicinal plants are still commonly used for the management of diabetes mellitus. This study synthesized scientific evidence on commonly used medicinal pl...

Authors: Serawit Deyno, Kassahun Eneyew, Sisay Seyfe and Elias Wondim

A randomized, open-label, multicentre, comparative study of therapeutic efficacy, preventive potential and tolerability of BNO 1030 extract, containing Althea root, Chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

Acute tonsillitis tends to recur. In cases where patients do not meet the Paradise criteria, the possibilities of non-surgical treatment are more often considered. The objective of this study was to evaluate t...

Authors: Vasyl Popovych, Ivana Koshel, Oleksandr Malofiichuk, Lubov Pyletska, Oleksandr Semenyuk, Oksana Martynnyk and Ruslana Orlovska

Phytochemical screening and anticancer activity of the aerial parts extract of Xanthium strumarium L. on HepG2 cancer cell line

Cancer is one of the most considerable concerns because of increasing the death rate all over the world. Recent studies have disclosed that plant extracts exhibit anticancer activity through various mechanisms. X...

Authors: Hai Trieu Ly, Trieu Minh Truong, Thi Thu Huong Nguyen, Hoang Dung Nguyen, Yuxia Zhao and Van Minh Le

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

The present study was designed to investigate the therapeutic effects against oxidative stress and alleviative effects of Peganum harmala seeds (PH) in rats with Complete Freund’s Adjuvant (CFA) induced arthritis...

Authors: Ashish Singhai and Umesh Kumar Patil

Composition and biological assays of the leaf essential oil of Asparagus flagellaris (Kunth) Bak

Asparagus flagellaris leaves are ethnomedicinally used to treat syphilis, gonorrhea and other sexually transmitted diseases (STDs), with no reports on the volatile constituents. This study was aimed to quantitati...

Authors: Oluwakayode O. Odeja, Michael Gabriel Ibok and Ejike O. Okpala

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the anxiolytic-like effects of Urena lobata L. (MEUL) methanolic extract in...

Authors: Muhammad Torequl Islam, Thoufiqul Alam Riaz, Seyed Abdulmajid Ayatollahi and Javad Sharifi-Rad

Efficacy of an herbal preparation based on lovage, rosemary, and centaury on patients after extracorporal shockwave lithotripsy

To study the effect of a herbal preparation containing a standardised BNO 1040 extract* (based on lovage root, rosemary leaves and aerial parts of centaury) on the extracorporeal shockwave lithotripsy (ESWL) r...

Authors: Volodymyr Frankovych Vitkovskyy

Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide

Authors: Noufissa Touiti, Tarik Sqalli Houssaini and Sanae Achour

Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model

Ziziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular and commonly known as “BAU Kul” in Bangladesh. This study was designed to ...

Authors: Md. Khokon Miah Akanda and A. H. M. Nazmul Hasan

Evaluation of anti-arthritic and anti-inflammatory activities of Martynia annua L. Ethanolic extract

Arthritis is a disorder of change in joint architecture and ligament degeneration. Rheumatoid arthritis is an autoimmune disorder in which body’s immune system targets own cells and degrade them. Martynia annua L...

Authors: Suruj Kaushik, Parag Jain, Trilochan Satapathy, Prerna Purabiya and Amit Roy

Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice

Authors: Valrielyn Saio, Donkupar Syiem, Ramesh Sharma and Careen Liza Pakyntein

Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis

Diabetes is a long-lasting and serious disease that effect in worldwide individual lives, families, and societies. Hyperglycemia of diabetes mellitus produced Advance Glycation End Products that are associated...

Authors: Ayesha Khan, Ajmal Khan, Manzoor Ahmad, Mumtaz Ali, Umar Farooq, Farhan Ahmad Khan and Syed Majid Bukhari

Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration of herbal medicine as alternatives. Also, the increasing rate of the use of herbal antimalarial...

Authors: Earnest Oghenesuvwe Erhirhie, Chidozie Ikegbune, Anthony Ifeanyi Okeke, Chukwunonso Chukwudike Onwuzuligbo, Ngozi Ukamaka Madubuogwu, Uche Maryann Chukwudulue and Onyinye Blessing Okonkwo

Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative ef...

Authors: Efosa Godwin Ewere, Ngozi Paulinus Okolie, Erhunmwunsee Dalton Avan and Patience Edet Umoh

Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. ...

Authors: Emmanuel Sina Akintimehin, Kayode Olayele Karigidi, Tope Samuel Omogunwa and Foluso Olutope Adetuyi

Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Azadirachta indica, Khaya senegalensis, Anogeissus leiocarpus and Tamarindus indica are important ethnomedicinal plants used for health mitigation since the history of mankind. They are used discretionarily in fo...

Authors: Abdullah M. Tauheed, Mohammed Mamman, Abubakar Ahmed, Na’imatu A. Sani, Mohammed M. Suleiman, Mohammed H. Sulaiman and Emmanuel O. Balogun

In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense)

Diabetes mellitus is a metabolic disorder of glucose metabolism and management of blood glucose level is the hallmark in the treatment of this disease. The present study investigated chemical composition, in v...

Authors: L. A. Sulaimon, E. O. Anise, E. M. Obuotor, T. A. Samuel, A. I. Moshood, M. Olajide and T. Fatoke

Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh

Thysanolaena maxima (Roxb.) Kuntze, a perennial grass plant, is usually distributed in hilly regions of the Indian Subcontinent. Different parts of T. maxima have been used as herbal medicine by traditional heale...

Authors: Nazia Hoque, Md. Hossain Sohrab, Farhana Afroz, Satyajit Roy Rony, Suriya Sharmin, Fatema Moni, Choudhury Mahmood Hasan and Md. Sohel Rana

Investigation of the nutritional value and antioxidant activities of common Bangladeshi edible mushrooms

Mushrooms have been recognized both as medicine and nutritional food in many countries for thousands of years, owing to the presence of significant amounts of carbohydrates, proteins, lipids, fibers, and antio...

Authors: Nazifa Sifat, Farhana Lovely, S. M. Neamul Kabir Zihad, Md. Golam Hossain, Jamil A. Shilpi, I. Darren Grice, Mohammad S. Mubarak and Shaikh Jamal Uddin

Lophira lanceolata protects testicular and spermatological damages induced by cisplatin in male Wistar rats

Chemotherapy is associated with male infertility. Cisplatin (CP), an antineoplastic agent has been successfully used for the treatment of diverse kinds of malignancies, however, the use of this effective agent...

Authors: Solomon Tsekohol Agu, Christian Okechukwu Ezihe, Paul Friday Itodo and Hyacinth Adakole Abu

Phytochemical screening and antioxidant, analgesic, and anthelmintic effect of ethanolic extract of Merremia umbellate stems

Merremia umbellata subsp. orientalis (Hallier f.), commonly known as Sapussunda in Bengali, is used in folk medicine for the treatment of different diseases such as helminthiasis, rheumatism, fever, wounds, burns...

Authors: Mst Nazmun Nahar, Amit Kumar Acharzo, Md Sohanur Rahaman, Iffat Ara Zabeen, Shariful Haque and Md Amirul Islam

Evidence-based management of acute rhinosinusitis with herbal products

The overuse of antibiotics for unjustified indications such as the management of acute uncomplicated rhinosinusitis has contributed to the emergence of antibiotic-resistant strains of bacteria and prompted the...

Authors: Claus Bachert

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Trend analysis, graphical representation, and summarization of pharmacological research trends were carried out to act as guidance for the future. The main objectives of the research are to find out the comple...

Authors: Shibam Karmakar, Somnath Paul, Nripendra Madhab Biswas, Jasmina Khanam, Sudip Kumar Kar, Hemanta Mukherjee and Sourav Poddar

In-Vitro antioxidant, anti-lipid peroxidative activities and In-Silico study of Terminalia chebula bioactive compounds

To evaluate the antioxidant activities and to identify the bioactive compounds in hot water extracts of Terminalia chebula fruit.

Authors: Syed Mubashar Sabir, Syed Rizwan Abbas, Shabnam Shahida and Muhammad Faraz Khan

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxico...

Authors: Reshu Tiwari, Mohammed Haris Siddiqui, Tarique Mahmood, Alvina Farooqui, Paramdeep Bagga, Farogh Ahsan and Arshiya Shamim

Correlative study of heavy metal content with biological importance of Solanum virginianum leaf extract

Rapid urbanization and industrialization have greatly impacted the inherent soil composition. Heavy metals disposed in the environment by anthropogenic activities toxicate flora and ultimately affect the phyto...

Authors: Biswash Guragain, Khem Raj Pant, Saugat Bhattarai and Narendra Kumar Chaudhary

Effects of Cnidium monnieri (L.) Cuss. fruit extract on sexual behaviors in male rats

Cnidium monnieri (L.) Cuss. has been used for a long time according to the traditional experiences and documentation in order to treat male sexual disorders. Osthole is one of the main bioactive components in Cni...

Authors: Thuy Duong Dau, Minh Ha Le, Tran Thi Giang Huong Nguyen, Thi Ngoc Mai Dang, Thi Nguyet Que Do and Quynh Trang Tran

Exploration of the role of a lithophytic fern, Pteris vittata L. in wound tissue regeneration and remodelling of genes in hyperglycaemic rat model

In hyperglycemic conditions like diabetes, impaired wound healing occurs due to endothelial damage, dysfunction of leukocyte, decreased phagocytosis and secondary infection which may lead to amputation and deb...

Authors: Tania S. Paul, Biswadeep B. Das, Yogesh P. Talekar and Suchitra Banerjee

Evaluation of in vivo wound healing activity of Moroccan Citrus reticulata peel extract

Citrus reticulata is one of the most cultivated fruit with great benefits for humans in the world. Citrus reticulata peel has several biological activities within them hypoglycemic, hepatoprotective, antimicrobia...

Authors: Sanae Dahmani, Rachida Chabir, Faouzi Errachidi, Wiam Berrada, Hafsa Lansari, Meryem Benidir, Lahsen El Ghadraoui and Abdellatif Bour

Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals

The present study was designed to investigate the in vivo wound healing activity of herbal ointment prepared from Calendula officinalis Linn. on excision wounded rats.

Authors: Shobana Gunasekaran, Agnel Arul John Nayagam and Rameshkannan Natarajan

Evaluation of Andira inermis stem bark extract for hypoglycaemic and antioxidant effects’

The aqueous methanolic extract of Andira inermis(A. inermis) stem bark was screened for phytochemical constituents, antioxidant activity, acute oral toxicity, and preliminary prophylactic normoglycaemic test and ...

Authors: Maxwell Osaronowen Egua, Florence Chimezie Nwinyi, Ode Julius Okwoche, Onakpa Micheal Monday, Akande Motunrayo Ganiyat, Onoja Samuel Okwudili, Mikail Hudu Garba, Akumka David Dezi and Adamu Mohammed

Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach

The practice of ethnomedicine remains to be the primary source of healthcare in many parts of the world, especially among the tribal communities. However, there is a lack of scientific outlook and investigatio...

Authors: Ananta Swargiary and Manita Daimari

Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced d...

Authors: Reyhane Javanshir, Moones Honarmand, Mehran Hosseini and Mina Hemmati

The in vivo toxicity evaluation of leaf and root methanolic extracts of Tephrosia vogelii Hook.f using animal model

Traditionally, herbal medicines are commonly used to cure several diseases since immemorial of human life. Nevertheless, the safety of some traditionally used medicinal plants is uncertain. Since Tephrosia vogeli...

Authors: Stephano Hanolo Mlozi, Juma A. Mmongoyo and Musa Chacha

Phytochemical and pharmacological activities of methanol extract of Artemisia vulgaris L. leaves

Artemisia vulgaris commonly known as “mugwort” is a very important medicinal plant which is used widely for the treatment of various ailments traditionally. The present studies aimed to conduct preliminary phytoc...

Authors: Nurpen Meitei Thangjam, Jasmina Taijong and Awadhesh Kumar

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel e...

Authors: Rosane Soh Matsinkou, Valere Aime Soh Oumbe, Judith Laure Ngondi and Julius Enyong Oben

The phytochemical and pharmacological screening of three crude extracts of Desmodium canum (strong back)

Desmodium canum (Strong Back) is deemed a versatile traditional medicine, where it is used to treat diabetes, hypertension, asthma and erectile dysfunction.

Authors: Ruby Lisa Alexander-Lindo, Roy Barrington Reynolds Porter, Chuckwuemeka Rapheal Nwokocha and Kemmoy Godfrey Lattibeaudiere

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

Obesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forc...

Authors: Kumaraswamy Athesh, Rangaraju Sivasubramanian, Gnanasekaran Jothi and Pemiah Brindha