Articles

Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity

Curative potential of Sida acuta Burm. f. (Malvaceae) leaves on hepatotoxicity and nephrotoxicity induced by carbon tetrachloride (CCl₄) and rifampicin was studied. This was aimed at providing a potent therapeuti...

Authors: Temidayo Ogunmoyole, Onaopemiposi Olufunke Falusi and Funmilayo Oderinde

Molecular interaction of bioactive compounds from Senecio biafrae leaf with α-amylase and α-glucosidase receptors

Diabetes mellitus is one of the silent killer diseases affecting millions of people globally and some of the key enzymes in managing this disease are α-amylase and α-glucosidase This study was designed to inve...

Authors: Basiru Olaitan Ajiboye

Current findings and future prospective of high-value trans Himalayan medicinal plant Lycium ruthenicum Murr: a systematic review

The genus Lycium is commercially known for its nutrient dense goji-berries, among these berries, black goji-berries obtained from Lycium ruthenicum Murr are highly valued and widely used as traditional medicine i...

Authors: Rajni Sharma, Rinky Raghuvanshi, Raj Kumar, Mohan Singh Thakur, Santosh Kumar, Manoj K. Patel, O. P. Chaurasia and Shweta Saxena

Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients

GlucoMedix® is an all-natural phytotherapy consisting of a hydro-alcoholic extract of Stevia rebaudiana (Bertoni) Bertoni and pentacyclic chemotype Uncaria tomentosa (Willd. Ex Schult.) DC. The nutraceutical prod...

Authors: Thomas P. Dooley, Johnny Martín Paredes Pérez and Carlos Rengifo Rodriquez

Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb.

Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has ...

Authors: Liton Sikder, Md. Roich Khan, Shanita Zaman Smrity, Muhammad Torequl Islam and Shams Ara Khan

Correction to: Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Authors: Julius Kevin Cura, Antonio Basilio and Ma. Cristina De Las Llagas

Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD).

Authors: Mac Donald Idu, Owen – Obaseki Edehia and Benjamin Ogunma Gabriel

Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Theobroma cacao Linn. husks are considered agricultural wastes, but studies show that they exhibit natural compounds that may be used in alternative medicine. Hence, this study was conducted to determine the anti...

Authors: Julius Kevin Cura, Antonio Basilio and Ma. Cristina De Las Llagas

Anti-diuretic and anti-glycemic properties of Jatropha gossypiifolia L. leave extract on wistar rats

Jatropha gossypiifolia L. is a widespread plant in tropical and sub-tropical countries used in traditional medicine. This study investigated the anti-diuretic and anti-hyperglycemia activities of J. gossypiifolia

Authors: Benjamin Ogunma Gabriel and Mac Donald Idu

Plantain based dough meal: nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high-fat induced rats

Dyslipidemia is an aberrant rise in blood lipids due to diet and lifestyle. It has implicated as the major risk factor for developing hypertension among other diseases. This study was designed to evaluate plan...

Authors: Timilehin David Oluwajuyitan, Oluwole Steve Ijarotimi and Tayo Nathaniel Fagbemi

Comparative studies on the hypoglycemic and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic rats

Vernonia amygdalina is a bitter culinary vegetable known to possess anti-diabetic principle. Baccharoides tenoreana belonging to the same species as V. amygdalina, is also used in cooking soup and it is comparati...

Authors: Samuel Chijioke Attama, Patrick Emeka Aba, Chinwe Uchechukwu Asuzu and Isaac Uzoma Asuzu

Toxicological studies of aqueous and ethanol leaf extract of Spondias purpurea (red plum) in rats

Spondias purpurea is a flowering plant of the cashew family commonly found in South Western Nigeria. The plant is used in folk medicine for treatment of gastric disorders and diarrhoea. The purpose of the study w...

Authors: T. Y. Gara, A. I. Daniel, F. M. Muhammad and H. H. Ndayako

Hypoglycaemic activity of Smilax canellifolia Mill. rhizomes: a bioassay-guided isolation and identification of synergistic compounds

Smilax canellifolia Mill. is a native shrub used in commercial root tonics as an aphrodisiac, stimulant, and pain reliever. Traditional medicine incorporates the rhizomes of S. canellifolia for the treatment of a...

Authors: Davia A. Peddie, Sophia J. Bryan, Sheena Francis and Ruby L. Alexander-Lindo

Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

The medicinal plant Citrullus colocynthis (L.) Schrad. (C. colocynthis) may benefit patients at different phases of diabetes by attuning to contrasting situations. Our primary objective was to find the mechanism(...

Authors: Arezoo Afshari, Fouzieh Salimi, Azin Nowrouzi, Masoumeh Babaie Khalili, Salar Bakhtiyari, Gholamreza Hassanzadeh, Maryam Shabani, Ali Ahadi and Masoumeh Farhadiannezhad

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone ...

Authors: Musa Bola Busari, Rabiat Unekwu Hamzah, Hadiza Lami Muhammad, Ruqayyah Shehu Yusuf, Fatima Mohammad Madaki, Jamiu Olabanji Adeniyi, Yunusa Olatunji Ibrahim and Eustace Bonghan Berinyuy

Correction to: Phytochemicals and in vitro anti-apoptotic properties of ethanol and hot water extracts of Cassava (Manihot esculenta Crantz) peel biogas slurry following anaerobic degradation

Authors: Oluwaseyi Paul Olaniyan and Ebenezer Idowu O. Ajayi

Evaluation of cerebroprotective effect of Ricinus communis leaves against ischemia reperfusion injury in rats

Ricinus communis (RC) has been used for a long time as natural origin medicine in the treatment of central nervous system ailments. This present study was designed to identify the possible role of Ricinus communi...

Authors: Nesar Ahmad, Anuradha Mishra, Farogh Ahsan and Zafar Khan

Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats

Pleurotus tuber-regium (P.T) is an edible mushroom with abundant polysaccharides that has been used in traditional medicine to treat diabetes mellitus. This study investigated the hypoglycaemic potential and amel...

Authors: Akindele Oluwatosin Adeyi, Folasade Ajoke Adams and Clementina Oyinkansola Adenipekun

Efficacy and safety of Cineole (Soledum®) in the treatment of patients with acute bronchitis: results of an open-label randomized clinical phase III study

Cineole has documented anti-inflammatory, expectorant, and mucolytic properties and has shown to be a valuable treatment option in different airway diseases. Our study examined whether a therapy with Cineole a...

Authors: Peter Kardos, Olga Khaletskaya and Olga Kropova

Baccharis trimera aqueous extract modulates inflammation and nociception in mice

The aerial parts of Baccharis trimera (Less.) are frequently used as a tea to treat several diseases. Therefore, the aim of this study was to identify the constituents of an aqueous extract of B. trimera, focusin...

Authors: Natiely Silveira de Almeida, Alexandre de Barros Falcão Ferraz, Claudia Pedron, Dione Silva Correa, Luciene Bruno Vieira, Flavia Tasmim Techera Antunes and Alessandra Hubner de Souza

Evaluation of bioactivity and phytochemical screening of endophytic fungi isolated from Ceriops decandra (Griff.) W. Theob, a mangrove plant in Bangladesh

Due to increasing number of individuals within the world having health issues caused by varied cancers, drug-resistant microorganism, parasitic protozoans, and fungi could be a cause for alarm. Endophyte’s are...

Authors: Mita Munshi, Md. Hossain Sohrab, Mst. Nadira Begum, Sattyajit Roy Rony, Md. Adnan Karim, Farhana Afroz and Md. Nazmul Hasan

Antioxidant and immunomodulatory effect of AKSS16-LIV01 – a multi herbal formulation against ethanol induced liver dysfunction in mice

Liver complication arises commonly due to high alcohol consumption rate. Majority of the people residing in both developed and under developed countries consuming alcohol face various liver complications such ...

Authors: Soumendra Darbar, Srimoyee Saha, Kausikisankar Pramanik and Atiskumar Chattopadhyay

Evaluation of clinical trials of the plants, which have ethnobotanical uses for skin disorders in Turkey: a review

Ethnobotanical studies investigating a large number of traditional herbs and uses have an important role in the discovery of new drugs. Nowadays, some of these traditional herbs are researched directly in the ...

Authors: Zinar Alan, Halil Özgüldü, Meryem Sedef Erdal, Ayşenur Yaman Bucak, A. Yağız Üresin and Emine Akalın

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

Malaria has continued to be a threat to man and his wellbeing, especially Africans and Asians. New antimalarial drugs are urgently needed to mitigate malaria treatment failure due to resistant Plasmodium species....

Authors: Osmond Chukwuma Enechi, Christian Chijioke Amah, Innocent Uzochukwu Okagu, Pamela Chidinma Ononiwu, Alice Chinwendu Nweke, Theophilus Chukwudi Ugwuanyi, Emmanuel Arinzechukwu Ajibo, Anthonia Chiamaka Nweze and Blessing Chiamaka Chukwurah

Phytochemicals and in vitro anti-apoptotic properties of ethanol and hot water extracts of Cassava (Manihot esculenta Crantz) peel biogas slurry following anaerobic degradation

Wastes emanating from cassava (Manihot Esculenta Crantz) processing in African countries significantly contribute to environmental pollution, besides, such toxic wastes contribute to greenhouse gas emission. Alth...

Authors: Oluwaseyi Paul Olaniyan and Ebenezer Idowu O. Ajayi

A formulation of Clausena anisata (Willd.) Hook. f. Ex Benth and Cassia sieberiana DC. alleviates the symptoms associated with osteoarthritis: a single-blind, randomised controlled trial of a traditional Ghanaian remedy

Clinical validation of herbal medicinal products is important for their widespread acceptance and application. In this single-blind, randomised controlled trial, a traditional Ghanaian herbal medicine formulat...

Authors: Kwesi Prah Thomford, Joseph Yorke, Ama Kyeraa Thomford and Isaac Kingsley Amponsah

Inhibition of phospholipase A2, platelet aggregation and egg albumin induced rat paw oedema as anti-inflammatory effect of Peltophorun pterocarpus stem-bark

Most medicinal plants presently employed in traditional medicine are used without scientific evidence, thereby suggesting a need to explore efficient and reliable investigations of their potential. We, therefo...

Authors: Osmund Chukwuma Enechi, Emmanuel Sunday Okeke, Ogochukwu Emmanuel Awoh, Charles Obinwanne Okoye and Chinaza Kyrian Odo

Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats

In the wake of antibiotic resistance, treatment of intractable wound have been very challenging and any alternative treatment which may lead to less use of antibiotics deserves further exploitation. Nanopartic...

Authors: Oluwatosin Kudirat Shittu, Olawale Issac Oluyomi and Theresa Yebo Gara

Impact of Althaea Officinalis extract in patients with atopic eczema: a double-blind randomized controlled trial

Althaea Officinalis introduced as an emerging anti-inflammatory agent with immunomodulatory effects that may suppress the symptoms of atopic eczema. In this study, we aimed to investigate the impact of liposomal ...

Authors: Negar Khalighi, Farahzad Jabbari-Azad, Maral Barzegar-Amini, Jalil Tavakkol-Afshari, Pouran Layegh and Roshanak Salari

A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19

COVID19 is a high burden for medicine and society as still no specific therapy exists. Most patients depend on symptomatic treatment, comparable to the symptomatic treatment in common respiratory infection e.g...

Authors: Vasyl Popovych, Ivana Koshel, Yulia Haman, Vitaly Leschak, Oleksandr Malofiichuk, Natalia Kapustina, Ihor Shevaga, Olha Shevaga and Tetiana Kunytska

Antiproliferative effect of extracts and fractions of the root of Terminalia avicennioides (Combretaceae) Guill and Perr. on HepG2 and Vero cell lines

Terminalia avicennioides Guill and Perr (Combretaceae) is an important West African medicinal plant. The plant is used locally against microbes and parasites in both humans and animals and studies have demonstrat...

Authors: Hadiza Aliyu-Amoo, Hamza Ibrahim Isa, Emmanuel Mfotie Njoya and Lyndy Joy McGaw

Correction to: An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Authors: Reshu Tiwari, Mohammed Haris Siddiqui, Tarique Mahmood, Alvina Farooqui, Paramdeep Bagga, Farogh Ahsan and Arshiya Shamim

Toxicological screening and evaluation of anti-allergic and anti-hyperglycemic potential of Sonneratia caseolaris (L.) Engl. fruits

Sonneratia caseolaris (L.) Engl. (S. caseolaris) belonging to the Sonneratiaceae family is commonly known as Ora. It is traditionally used as an astringent, antiseptic, to treat sprains, swellings, cough and in a...

Authors: Shrabanti Dev, Rabindra Nath Acharyya, Sheuly Akter, Md. Abdullah Al Bari, Kaniz Asma, Hemayet Hossain, Kishore Kumar Sarkar, Nripendra Nath Biswas and Asish Kumar Das

Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India

Cognitive impairment mainly affects learning and problem solving abilities of the person. Traditional medicines, due to fewer side effects, more efficacy and lesser cost are still the choice of treatment in In...

Authors: Sapna Saini, Manjusha Choudhary and Ankur Garg

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

This study was designed to evaluate the protective effects of a Rhamnus alaternus aqueous extract (RAAE) on aluminum chloride-induced hepatotoxicity in rats. A preliminary phytochemical study and antioxidant acti...

Authors: Chahrazed Benzaid, Lazhari Tichati, Fouzia Trea, Mahmoud Rouabhia and Kheireddine Ouali

Toxicological evaluation of the dried hydroethanolic extract of Amaranthus spinosus L. roots in Artemia salina larvae and Sprague Dawley rats

Amaranthus spinosus is a medicinal plant used in traditional medicine to treat several diseases including diabetes and its complications. The aim of this study was to prove the safety of the plant in animal healt...

Authors: Kokou Atchou, Povi Lawson-Evi, Aboudoulatif Diallo and Kwashie Eklu-Gadegbeku

Cardiovascular benefits of Momordica charantia in cholesterol-fed Wistar rats

Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated the beneficial effects of the ethanolic extract of M. charant...

Authors: Silvanus Olu Innih, Ikechi Gerald Eze and Kingsley Omage

Cure and prevention of cardiovascular diseases: herbs for heart

Herbs contribute to more than 60-70% in development of modern medicines in the world market either directly or indirectly. The herbal treatments for congestive heart failure, systolic hypertension, angina, ath...

Authors: Suman Ray and Mahesh Kumar Saini

Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study

Fenugreek (Trigonella foenum-graecum) seed is a popular kitchen spice and medicinal herb with wide applications in Indian folklore. Earlier studies have shown that the hydro-ethanolic extracts of fenugreek are ef...

Authors: Aman Khanna, Jestin Thomas, Febi John, Balu Maliakel and I. M. Krishnakumar

Effect of wound healing in gels containing tinctures of Alnus glutinosa (L) leaves

Alnus glutinosa (L) is a widespread medicinal plant on the territory of the Republic of Belarus. Alnus glutinosa (L) leaves tincture has an anti-inflammatory effect on the diseases of the throat, intestines, in r...

Authors: Volha Mushkina

Preliminary toxicology profile of Dennettia tripetala (Pepper Fruit) methanolic leaves extract

Dennentia tripetalla (Pepper Fruit) belongs to the Annonaceae family and is abundant in Nigeria. Its fruit in folklore medicine is used for treatment of varying ailments. While ample research evidence exists on t...

Authors: Joseph Chukwufumnanya Mordi, Patrick Chukwuyenum Ichipi-Ifukor, Godfery Rume Kweki, Rita Ngozi Ichipi-Ifukor, John Chukwuma Oyem and Uche Dennis-Eboh

Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review

Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Earlier to the innovation of synthetic drugs, human beings completely relied on the plants for the treatment of variou...

Authors: Devanesan Arul Ananth, Garlapati Deviram, Vijayaraghavan Mahalakshmi and V. Ratna Bharathi

Phytotoxicity, cytotoxicity and chemical composition of Spondias mombin Linn. Stem bark

Spondias mombin Linn. is a tropical climate plant with wide applications in ethnomedicinal practice. This study evaluates the phytotoxicity, cytotoxicity and chemical composition of the plant’s stem bark.

Authors: Kissinger Obaogie Orumwensodia, Patrick Ojeifo Uadia and Muhammed Iqbal Choudhary

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammat...

Authors: Luis Ângelo Macedo Santiago, Roberval Nascimento Moraes Neto, Ana Caroline Santos Ataíde, Dâmaris Cristina Sousa Carvalho Fonseca, Enio Fernandes Aragão Soares, Joicy Cortez de Sá Sousa, Renata Mondego-Oliveira, Rachel Melo Ribeiro, Maria do Socorro de Sousa Cartágenes, Lídio Gonçalves Lima-Neto, Rafael Cardoso Carvalho and Eduardo Martins de Sousa

Root extracts of Anacardium occidentale reduce hyperglycemia and oxidative stress in vitro

Hyperglycemia is the hallmark of diabetes, and the associated oxidative stress is a major concern that invites an array of diabetic complications. The traditional practices of medicare are of great, current in...

Authors: TM Archana, K Soumya, Jesna James and Sudheesh Sudhakaran

Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre

Gymnema sylvestre is a reputable medicinal plant commonly explore for the management of diabetes and other ailments in traditional medicine. In the present study, we investigated the phytochemical compositions an...

Authors: Rofiyat Omolara Raji, Hadiza Lami Muhammad, Abdulkadir Abubakar, Sophia Shekwoyan Maikai and Habibat Feyishara Raji

Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characte...

Authors: Olubanke O. Ogunlana, Babatunde O. Adetuyi, Miracle Rotimi, lohor Esalomi, Alaba Adeyemi, Julie Akinyele, Oluseyi E. Ogunlana, Oluwatosin A. Adetuyi, Oluwaseun A. Adebisi, Edward K. Opata, Roua S. Baty and Gaber El-Saber Batiha

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding ...

Authors: Olumide Samuel Fadahunsi, Peter Ifeoluwa Adegbola, Olubukola Sinbad Olorunnisola, Temitayo Idris Subair, David Oluwasegun Adepoju and Ayodeji Zabdiel Abijo

Variation for caffeic acid and phenolic content in different plant parts of Solanum xanthocarpum Schrad. and Wendl. – a commercially important dashmool species

Environmental factors have profound effect on quantity vis-a-vis quality of phytochemicals in medicinal plants. Solanum xanthocarpum Schrad. and Wendl. is among the 10 dashmool species which is utilized in more t...

Authors: Hari Om Saxena, Samiksha Parihar, Naseer Mohammad and Ganesh Pawar

Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review

Black pepper [Piper nigrum (L.), Family: Piperaceae] is used traditionally for the treatment of various diseases including; cough, cold, dyspnea throat diseases, intermittent fever, dysentery, stomachache, worms ...

Authors: Kaliyaperumal Ashokkumar, Muthusamy Murugan, M. K. Dhanya, Arjun Pandian and Thomas D. Warkentin