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International Journal of Phytomedicine and Phytotherapy

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Table 1 Short description of clinical studies with Cimiciduga racemosa preparations

From: Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

Ref. (placebo or comparator controlled) Design Patient characteristics and age Treatment, dose, and duration Outcome measures Finding and comments Effects in short
No = Ø
Signif. pos = +
Signif. neg = −
Wuttke et al., 2003 [34] Randomized, double-blind, comparator and placebo-controlled 64 early postmenopausal women with 3 or more hot flushes daily Aquous-ethanolic CR extract BNO 1055 (40 mg dried rhizome powder daily (equivalent to 4.5-8.9 mg dried extract)) vs 0.6 mg conjugated estrogens vs placebo. Duration, 3 mo Menopause Rating Scale I. Frequency of nocturnal wake-up periods Significantly better improvement of most climacteric complaints under CR an CE in comparison to placebo, +
Osmers et al. 2005 [41] Randomized, double-blind, placebo-controlled 304 early post-menopausal women Isopropanolic CR extract (40 mg dried rhizome powder daily (equivalent to 5 mg dreid extract)), duration 12 weeks Menopause Rating scale I. Significantly better improvement of most climacteric complaints under CR an CE in comparison to placebo, +
Nappi et al. 2005 [42] Randomized, comparator controlled trial 64 postmenopausal women Isopropanolic CR extract (40 mg dried rhizome powder daily (equivalent to 5 mg dried extract)) vs low-dos transdermal estradiol, duration 3 months Diary recorded number of hot flushes per day Identical improvement under CR and transdermal E2 +
Frei-Kleiner et al. 2005 [43] Randomized, double-blind, placebo-controlled trial 122 postmenopausal women with 3 or more hot flushes per day CR extracr Cr 99 vs placebo, duration 12 weeks Kupperman Index and Menopause Rating Scale Significant superiority of the CR extract in comparison to placebo. +
Pockaj et al. 2006 Randomized, double-blind, placebo-controlled, trial, cross-over design 132 postmenopausal women 2x20 mg of a CR extract (probably equivalent to 2x200 mg dried root powder) for 4 weeks, then crossover to verum or placebo respectively Hot flush score Slightly better improvement under placebo in comparison to verum. -
Note: The dose was approximately 10-fold higher than in all other studies which had a positive outcome
  1. CE conjugated oestrogens, CR Cimicifuga racemosa, DB double blind, GCS greene climacteric scale, KMI Kupperman menopause index, MRS menopause rating scale, PM postmenopausal, RCT randomised controlled trial