Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays

Orhan, Ilkay Erdogan; Senol, Fatma Sezer; Haznedaroglu, Mehmet Zeki; Koyu, Halil; Erdem, Sinem Aslan; Yılmaz, Gulderen; Cicek, Mehmet; Yaprak, A. Emre; Ari, Esin; Kucukboyaci, Nurgun; Toker, Gulnur

doi:10.1186/s40816-016-0023-6

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 AChE, BChE, and TYR inhibitory effects of the extracts at 100 μg mL^-1

From: Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays

Species	Plant part	Extract type	Inhibitory effect of the extracts (% ± S.E.M.^a)
Species	Plant part	Extract type	AChE	BChE	TYR
AL^b	Fruit	DCM	-^c	14.23 ± 1.22^****	26.55 ± 1.42^****
		EtOAc	-	7.56 ± 2.00^****	27.21 ± 2.55^****
		EtOH	-	-	24.23 ± 1.33^****
AL^b	Aerial	DCM	-	-	21.78 ± 0.91^****
		EtOAc	-	-	22.12 ± 0.09^****
		EtOH	-	10.19 ± 0.56^****	27.30 ± 2.20^****
EE	Fruit	Juice	-	2.15 ± 0.78^****	1.33 ± 0.68^****
	Fruit	EtOH	-	15.90 ± 1.93^****	6.18 ± 2.39^****
	Aerial	EtOH	-	8.16 ± 1.80^****	-
	Root	EtOH	1.71 ± 0.42^****	15.98 ± 2.94^****	4.92 ± 0.77^****
CER	Aerial	EtOAc	51.33 ± 3.35^**	15.21 ± 1.32^****	8.00 ± 1.65^****
CER	Aerial	MeOH	-	10.42 ± 1.43^****	4.38 ± 0.68^****
CET	Aerial	EtOAc	-	11.52 ± 3.19^****	2.24 ± 0.15^****
CET	Aerial	MeOH	-	11.55 ± 3.27^****	1.52 ± 0.14^****
CM	Aerial	EtOAc	-	13.19 ± 1.26^****	-
CM	Aerial	MeOH	-	14.48 ± 0.24^****	6.24 ± 1.15^****
CS	Aerial	EtOAc	4.20 ± 0.04^****	10.05 ± 1.46^****	-
CS	Aerial	MeOH	6.55 ± 1.90^****	9.85 ± 1.84^****	15.10 ± 0.30^****
CT	Aerial	EtOAc	12.69 ± 1.70^****	13.03 ± 1.64^****	-
CT	Aerial	MeOH	14.67 ± 1.80^****	10.32 ± 1.85^****	22.14 ± 2.62^****
RC (wild)	Aerial	EtOH	-	-	4.36 ± 1.23^****
RC (cultivated)	Aerial	EtOH	-	-	-
CG	Aerial	EtOH	-	-	-
VH	Aerial	EtOH	-	-	3.67 ± 0.42^****
OH^b	Aerial	MeOH	22.36 ± 2.93^****	66.88 ± 0.17^**	35.28 ± 1.90^****
OH^b	Aerial	Aqueous	-	-	-
ZN	Aerial	EtOH	-	-	-
ZM	Leaf	EtOH	-	5.39 ± 0.40^****	6.34 ± 1.21^****
PO	Leaf	EtOH	10.03 ± 3.00^****	3.18 ± 1.65^****	-
	Rhizome	EtOH	15.77 ± 4.68^****	25.82 ± 1.32^****	5.69 ± 1.35^****
	Root	EtOH	61.88 ± 2.23^**	82.55 ± 2.14^**	17.04 ± 1.31^****
Galanthamine^d			92.13 ± 1.47	89.95 ± 0.87
Alpha-kojic acid^e					87.62 ± 0.23

^aStandard error mean (n = 3)
^bTested at 200 μg mL^-1
^cNo inhibitory activity
^dReference for AChE and BChE inhibitory effect at 100 μg mL^-1
^e Reference for TYR inhibitory effect at 200 μg mL^-1
[^* p < 0.05; ^** p < 0.01; ^*** p < 0.001, ^**** p < 0.0001]

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