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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Fig. 4 | Clinical Phytoscience

Fig. 4

From: Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

Fig. 4

Concentration-dependent inhibition of 5-LO (purified enzyme) activity and 5-LO product formation in human monocytes by BNO 1095. a Cell-free 5-LO enzyme inhibition by BNO 1095 using purified human recombinant 5-LO. b Inhibition of 5-LO product (sum of LTB4, trans-LTB4, epi-LTB4 and 5-H(p)ETE) formation and LTC4 production by BNO 1095 in a cell-based (human monocyte) in vitro assay. 0.5 % ethanol served as vehicle control. Data are given as means ± SEM, n = 3

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