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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of C. diffusa extract and diazepam on hole cross test

From: Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Treatment

Dose

(mg/kg)

Number of hole crossed

0 min

30 min

60 min

90 min

120 min

Control

0.1 mL/mouse

16.40 ± 0.92

12.40 ± 1.12

9.40 ± 0.51

6.60 ± 0.81

4.00 ± 0.70

Diazepam

1

14.00 ± 1.41

5.40 ± 0.51*

3.40 ± 0.24*

1.20 ± 0.37*

0.60 ± 0.24*

MECD

50

14.40 ± 1.69

7.60 ± 0.40*

6.20 ± 1.02*

3.00 ± 0.54*

2.40 ± 0.51

MECD

100

13.40 ± 0.92

6.60 ± 0.74*

5.00 ± 0.89*

2.40 ± 0.67*

1.60 ± 0.51*

MECD

200

15.00 ± 0.83

6.40 ± 0.51*

4.20 ± 0.37*

1.80 ± 0.37*

1.00 ± 0.31*

  1. Values are presented as mean ± SEM (n = 5). MECD = Methanolic extract of C. diffusa
  2. * p < 0.05, vs. control (Dunnett’s test)
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