International Journal of Phytomedicine and Phytotherapy
Table 3 Results of the analgesic activity of the total ethanolic extract and different fractions of A. hirtum leaves in mice using the hot plate method
Group | Time (sec) | ||||||
|---|---|---|---|---|---|---|---|
0 h | 30 min | 1 h | 2 h | 3 h | 4 h | 5 h | |
Control (−ve) | 58 ± 2.51 | 60.67 ± 0.88 | 62 ± 2.30 | 61.33 ± 1.85 | 59.33 ± 2.02 | 59.5 ± 1.55 | 59 ± 1.47 |
Total extract (300 mg/kg) | 60.25 ± 1.88 | 57.5 ± 1.32 | 94.25 ± 4.42*** | 94 ± 5*** | 152.7 ± 3.28*** | 159.8 ± 4.19*** | 167 ± 3.34*** |
Petroleum ether fraction (300 mg/kg) | 59 ± 2.48 | 60.75 ± 1.93 | 72.25 ± 3.98 | 97 ± 1.68*** | 138.3 ± 7.51*** | 167.3 ± 2.72*** | 171 ± 1*** |
Chloroform fraction (300 mg/kg) | 64.33 ± 1.76 | 68.67 ± 3.84 | 75.5 ± 5.31 | 94.33 ± 4.66*** | 112 ± 4.20*** | 156.7 ± 7.83*** | 169.3 ± 5.72*** |
Ethyl acetate fraction (300 mg/kg) | 52.25 ± 3.19 | 55 ± 0.57 | 57.25 ± 1.75 | 57.75 ± 3.49 | 63.5 ± 2.53 | 59.25 ± 1.93 | 58.75 ± 2.95 |
Aqueous fraction (300 mg/kg) | 62.5 ± 2.32 | 75.33 ± 2.84** | 86 ± 4.91** | 94.75 ± 2.72*** | 108 ± 6.24*** | 155.3 ± 3.70*** | 186.8 ± 5.51*** |
Acetylsalicylic acid (100 mg/kg) | 56.25 ± 1.70 | 67.5 ± 3.61 | 71.5 ± 3.66 | 79 ± 2.48** | 93.67 ± 4.37*** | 131.7 ± 5.20*** | 169 ± 7.37*** |