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International Journal of Phytomedicine and Phytotherapy

Table 3 Results of the analgesic activity of the total ethanolic extract and different fractions of A. hirtum leaves in mice using the hot plate method

From: Anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Abutilon hirtum (Lam.) Sweet

Group Time (sec)   
  0 h 30 min 1 h 2 h 3 h 4 h 5 h
Control (−ve) 58 ± 2.51 60.67 ± 0.88 62 ± 2.30 61.33 ± 1.85 59.33 ± 2.02 59.5 ± 1.55 59 ± 1.47
Total extract (300 mg/kg) 60.25 ± 1.88 57.5 ± 1.32 94.25 ± 4.42*** 94 ± 5*** 152.7 ± 3.28*** 159.8 ± 4.19*** 167 ± 3.34***
Petroleum ether fraction (300 mg/kg) 59 ± 2.48 60.75 ± 1.93 72.25 ± 3.98 97 ± 1.68*** 138.3 ± 7.51*** 167.3 ± 2.72*** 171 ± 1***
Chloroform fraction (300 mg/kg) 64.33 ± 1.76 68.67 ± 3.84 75.5 ± 5.31 94.33 ± 4.66*** 112 ± 4.20*** 156.7 ± 7.83*** 169.3 ± 5.72***
Ethyl acetate fraction (300 mg/kg) 52.25 ± 3.19 55 ± 0.57 57.25 ± 1.75 57.75 ± 3.49 63.5 ± 2.53 59.25 ± 1.93 58.75 ± 2.95
Aqueous fraction (300 mg/kg) 62.5 ± 2.32 75.33 ± 2.84** 86 ± 4.91** 94.75 ± 2.72*** 108 ± 6.24*** 155.3 ± 3.70*** 186.8 ± 5.51***
Acetylsalicylic acid (100 mg/kg) 56.25 ± 1.70 67.5 ± 3.61 71.5 ± 3.66 79 ± 2.48** 93.67 ± 4.37*** 131.7 ± 5.20*** 169 ± 7.37***
  1. The results are presented as the mean ± S.E.M Standard error of the mean. Differences with respect to the control group were calculated using the student’s T-test (*P < 0.05, **P < 0.01, ***P < 0.001)