International Journal of Phytomedicine and Phytotherapy
Table 6 Results of anti-diabetic activity of the total ethanolic extract and different fractions of A. hirtum leaves on streptozotocin-induced hyperglycemia
Group | Blood glucose level (mg/dl) | ||||||
|---|---|---|---|---|---|---|---|
0 h (fasting) | 30 min | 1 h | 2 h | 3 h | 4 h | 5 h | |
Control (−ve) | 203.3 ± 2.32 | 201.8 ± 1.79 | 201.3 ± 1.49 | 202.8 ± 1.93 | 207.3 ± 1.93 | 208.5 ± 1.70*** | 208.8 ± 2.78*** |
Total extract (300 mg/kg) | 202.3 ± 1.79 | 201.8 ± 1.25 | 184 ± 2.64 | 150 ± 2.08*** | 145.5 ± 2.75*** | 123.3 ± 3.32*** | 109 ± 4.54*** |
Petroleum ether fraction (300 mg/kg) | 206.3 ± 1.70 | 199 ± 5.05 | 183.5 ± 4.34 | 158.5 ± 4.69*** | 142.5 ± 3.5*** | 129.3 ± 4.90*** | 109 ± 5.35*** |
Chloroform fraction (300 mg/kg) | 206.8 ± 2.32 | 195.8 ± 3.63 | 174.8 ± 2.72** | 149 ± 4.69*** | 141.5 ± 3.40*** | 124.5 ± 4.57*** | 104.3 ± 3.03*** |
Ethyl acetate fraction (300 mg/kg) | 205 ± 2.85 | 202.8 ± 2.62 | 161.3 ± 5.48*** | 150.5 ± 5.12*** | 142 ± 3.87*** | 113.5 ± 3.86*** | 104.8 ± 2.01*** |
Aqueous fraction (300 mg/kg) | 205.3 ± 3.56 | 204.3 ± 3.63 | 181.3 ± 5.51* | 160 ± 4.93*** | 153.5 ± 2.63*** | 138.5 ± 3.5*** | 112 ± 5.5*** |
Crude polysaccharides (300 mg/kg) | 207.3 ± 3.77 | 199.8 ± 1.25 | 172.7 ± 6.83** | 96.3 ± 6.36*** | 87.25 ± 6.30*** | 72.25 ± 5.28*** | 39.5 ± 2.5*** |
Metformin (150 mg/kg) | 204 ± 2.64 | 199 ± 1.35 | 166.5 ± 6.70*** | 137.8 ± 3.19*** | 126.5 ± 2.21*** | 113 ± 4.54*** | 93 ± 4.08*** |