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International Journal of Phytomedicine and Phytotherapy

Table 6 Results of anti-diabetic activity of the total ethanolic extract and different fractions of A. hirtum leaves on streptozotocin-induced hyperglycemia

From: Anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Abutilon hirtum (Lam.) Sweet

Group Blood glucose level (mg/dl)   
  0 h (fasting) 30 min 1 h 2 h 3 h 4 h 5 h
Control (−ve) 203.3 ± 2.32 201.8 ± 1.79 201.3 ± 1.49 202.8 ± 1.93 207.3 ± 1.93 208.5 ± 1.70*** 208.8 ± 2.78***
Total extract (300 mg/kg) 202.3 ± 1.79 201.8 ± 1.25 184 ± 2.64 150 ± 2.08*** 145.5 ± 2.75*** 123.3 ± 3.32*** 109 ± 4.54***
Petroleum ether fraction (300 mg/kg) 206.3 ± 1.70 199 ± 5.05 183.5 ± 4.34 158.5 ± 4.69*** 142.5 ± 3.5*** 129.3 ± 4.90*** 109 ± 5.35***
Chloroform fraction (300 mg/kg) 206.8 ± 2.32 195.8 ± 3.63 174.8 ± 2.72** 149 ± 4.69*** 141.5 ± 3.40*** 124.5 ± 4.57*** 104.3 ± 3.03***
Ethyl acetate fraction (300 mg/kg) 205 ± 2.85 202.8 ± 2.62 161.3 ± 5.48*** 150.5 ± 5.12*** 142 ± 3.87*** 113.5 ± 3.86*** 104.8 ± 2.01***
Aqueous fraction (300 mg/kg) 205.3 ± 3.56 204.3 ± 3.63 181.3 ± 5.51* 160 ± 4.93*** 153.5 ± 2.63*** 138.5 ± 3.5*** 112 ± 5.5***
Crude polysaccharides (300 mg/kg) 207.3 ± 3.77 199.8 ± 1.25 172.7 ± 6.83** 96.3 ± 6.36*** 87.25 ± 6.30*** 72.25 ± 5.28*** 39.5 ± 2.5***
Metformin (150 mg/kg) 204 ± 2.64 199 ± 1.35 166.5 ± 6.70*** 137.8 ± 3.19*** 126.5 ± 2.21*** 113 ± 4.54*** 93 ± 4.08***
  1. The results are presented as the mean ± S.E.M Differences with respect to the control group were calculated using the student’s T- test (*P < 0.05, **P < 0.01, ***P < 0.001)