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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Toxicity and ADME analysis of the phytoconstitiuents isolated from Piper sylvaticum by Swiss ADME Analysis and Molinspiration Cheminformatics software

From: Anthelmintic activity of Piper sylvaticum Roxb. (family: Piperaceae): In vitro and in silico studies

Compound name

Molecular weighta (g/mol)

H-donorb

H-acceptorc

LogP valued

Molar refractivitye

Piperine

285.34

0

3

3.33

85.47

Piperlonguminine

273.33

1

3

3.30

78.77

N-isobutyl deca-trans-2-trans-4-dienamide

223.35

1

1

4.26

71.47

  1. aMolecular weight accepted range < 500
  2. bHydrogen bond donor acceptable range ≤ 5
  3. cHydrogen bond acceptor acceptable range ≤ 10
  4. dHigh lipophilicity (expressed as LogP, Acceptable range < 5)
  5. eMolar refractivity should be between 40 and 130
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