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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of methanolic extract of the L. sativus L. seeds on open field test in mice

From: Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Group

Number of Movements(Mean ± SEM)

0 min

30 min

60 min

90 min

120 min

Group-I

57.50 ± 2.50

50.50 ± 2.50

46.67 ± 1.76

45.33 ± 5.33

34.67 ± 2.60

Group-II

45.00 ± 2.00

33.00 ± 2.00*

31.33 ± 2.03**

15.33 ± 0.88**

24.00 ± 1.53**

Group-III

38.50 ± 1.50**

32.50 ± 2.50*

32.00 ± 2.00**

23.33 ± 1.45*

9.33 ± 0.33***

Group-IV

36.50 ± 0.50

29.50 ± 0.50*

20.67 ± 3.04**

4.33 ± 0.33**

2.67 ± 0.33***

  1. Values are represented as mean ± SEM, (n = 5). Group I (control) animals received vehicle (1% Tween 80 in water), Group II (standard) received diazepam 1 mg/kg body weight, Group III and Group IV were treated with 200 and 300 mg/kg body weight (p.o.) of the methanolic extract of L. sativus L. seeds, respectively. ***indicates P < 0.001, **indicates P < 0.01 and *indicates P < 0.05; one-way ANOVA followed by Dunnett’s test as compared to control