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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 Effect of methanolic extract of the L. sativus L. seeds on formalin induced writhing in mice

From: Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Groups

Licking number (Mean ± SEM)

% Inhibition

Early phase (0–5 min)

Late phase (10–15 min)

Early phase (0–5 min)

Late phase (10–15 min)

Group-I

13.25 ± 0.63

9.75 ± 0.85

–

–

Group-II

6.00 ± 0.41

2.75 ± 0.25

54.72

71.79

Group-III

7.50 ± 0.65**

5.25 ± 0.63**

43.39

46.15

Group-IV

4.75 ± 0.48**

0.25 ± 0.25***

64.15

97.44

  1. Values are expressed as mean ± SEM (n = 5). Group I (control) animals received vehicle (1% Tween 80 in water), Group II (standard) received indomethacin 10 mg/kg body weight, Group III and Group IV were treated with 200 and 400 mg/kg body weight (p.o.) of the methanolic extract of L. sativus L. seeds, respectively. ***indicates P < 0.001, and **indicates P < 0.01; one-way ANOVA followed by Dunnett’s t-test as compared to control. MLSS = Methanolic extract of L. sativus L. seeds
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