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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 6 Effect of methanol extract of L. sativus L. seeds on 2, 4-Dinitrophenol (DNP) induced pyrexia in mice

From: Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Treatment

Temperature in °C

Initial

Pyretic

1 h

2 h

3 h

4 h

Group-I

36.23 ± 0.69

37.23 ± 0.55

37.22 ± 0.54

37.01 ± 0.5

37.01 ± 0.50

36.95 ± 0.49

Group-II

34.95 ± 0.28

36.09 ± 0.22

35.79 ± 0.30*

35.24 ± 0.29*

35.08 ± 0.27*

35.00 ± 0.28*

Group-III

35.97 ± 0.73

36.93 ± 0.78

36.79 ± 0.76

36.41 ± 0.82

36.29 ± 0.77

36.22 ± 0.82

Group-IV

34.86 ± 0.13

36.09 ± 0.19

35.87 ± 0.13

35.25 ± 0.16*

35.08 ± 0.14*

34.87 ± 0.13**

  1. Values are expressed as mean ± SEM (n = 5). Group I (control) animals received distilled water (10 ml/kg), Group II (standard) received aspirin 150 mg/kg body weight, Group III and Group IV were treated with 200 and 400 mg/kg body weight (p.o.) of the methanolic extract of L. sativus L. seeds, respectively. ***indicates P < 0.001, and **indicates P < 0.01; one-way ANOVA followed by Dunnett’s t-test as compared to control. MLSS = Methanolic extract of L. sativus L. seeds
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