Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of methanol extract of T. conophorum seeds on liver antioxidant status in CCl4 induced hepatotoxicity in rats after 24 h of intoxication

From: Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats

Treatment Parameters
(n = 5) CAT (Unit/mg protein) SOD (Unit/mg protein) GPx (Unit/mg protein) GST (Unit/mg protein GSH (μg/mg protein
Group1A 32.20 ± 1.20 6.00 ± 0.50 4.20 ± 0.22 0.53 ± 0.03 14.50 ± 0.25
Group IIA ***16.42 ± 1.12a ***2.55 ± 0.08a ***2.69 ± 0.10a **0.30 ± 0.05a ***6.41 ± 0.15
Group IIIA ***30.25 ± 0.50b ***5.50 ± 0.15b ***4.12 ± 0.11b *0.50 ± 0.05b ***18.20 ± 0.45
Group IVA ***25.50 ± 0.55b *3.50 ± 0.05b **3.46 ± 0.05b 0.35 ± 0.01a ***15.20 ± 0.40
Group VA ***28.00 ± 0.40b ***5.06 ± 0.20b **3.43 ± 0.02b *0.45 ± 0.05b ***15.00 ± 0.06
GroupVIA ***23.30 ± 0.30b 2.80 ± 0.08b 3.13 ± 0.04b 0.32 ± 0.03b ***15.70 ± 0.16
GroupVIIA ***27.62 ± 0.60b **4.00 ± 0.12b ***3.54 ± 0.09b 0.40 ± 0.01a ***16.20 ± 0.20
  1. Values are Mean ± SEM, n = 5 rats in each group, *P˂0.05; **p < 0.01; ***p < 0.001, a as compared with the normal saline (control) group; b as compared with the CCl4 only group SOD Superoxide dismutase; CAT Catalase; GPx Glutathione peroxidase; GST Glutathione-S-Transferase
  2. Group IA (control) received distilled water and olive oil (i.p), group IIA rats were intoxicated with CCl4 in olive oil (600 mg/kg, i.p.) only on the 8th day, while groups IIIA, IVA and VA were given 100 mg/kg of silymarin, 250 mg/kg and 500 mg/kg of methanol extract respectively for 7 days, thereafter intoxicated with CCl4 on the 8th day. Groups VIA and VIIA were intoxicated with CCl4 on the 8th day and administered 250 mg/kg and 500 mg/kg of methanol extract of T. conophorum seeds at 1 h, 6 h, 12 h, 18 h and 24 h. Fasting blood samples were collected after the last administration of the extract at 24 h of intoxication with CCl4