Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of methanol extract of T. conophorum seeds on liver antioxidant status in CCl₄ induced hepatotoxicity in rats after 24 h of intoxication

Values are Mean ± SEM, n = 5 rats in each group, *P˂0.05; **p < 0.01; ***p < 0.001, a as compared with the normal saline (control) group; b as compared with the CCl₄ only group SOD Superoxide dismutase; CAT Catalase; GPx Glutathione peroxidase; GST Glutathione-S-Transferase
Group IA (control) received distilled water and olive oil (i.p), group IIA rats were intoxicated with CCl₄ in olive oil (600 mg/kg, i.p.) only on the 8th day, while groups IIIA, IVA and VA were given 100 mg/kg of silymarin, 250 mg/kg and 500 mg/kg of methanol extract respectively for 7 days, thereafter intoxicated with CCl₄ on the 8th day. Groups VIA and VIIA were intoxicated with CCl₄ on the 8th day and administered 250 mg/kg and 500 mg/kg of methanol extract of T. conophorum seeds at 1 h, 6 h, 12 h, 18 h and 24 h. Fasting blood samples were collected after the last administration of the extract at 24 h of intoxication with CCl₄