Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 Effect of S. nigrum on CCl₄ -induced changes in SDH and ATPase activities

Experimental groups	SDH	ATPase
Control
1. Untreated	61.12 ± 2.12	0.35 ± 0.12
2. Olive oil	61.89 ± 1.12	0.35 ± 0.09
3. S. nigrum (SN)	61.01 ± 0.44	0.34 ± 0.11
Carbon Tetrachloride (CCl₄) -Treated
4. CCl₄	33.23 ± 1.24^a*	0.17 ± 0.02^a*
(V) CCl₄ + Solanum Nigrum (SN) Extract-Treated
5. CCl₄ + SN100	43.28 ± 0.66^b*	0.24 ± 0.55^b*
6. CCl₄ + SN200	46.02 ± 0.54^b*	0.25 ± 0.90^b*
7. CCl₄ + SN300	47.29 ± 0.33^b*	0.28 ± 0.76^b*

Results are expressed as mean ± SEM; n = 10
No significant difference was noted between groups 1–3
^aas compared between vehicle control (group 2) and toxin-treated (group 4),
^bas compared between toxin-treated (group 4) and toxin - + antidote-treated (groups 5–7)
Level of significance ^*p < 0.001
Units: SDH - μg formazon formed/mg protein/15 min; ATPase - μmoles i.p. released/mg protein/30 min