Effect of Ganoderma lucidum on memory and learning in mice

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of Ganoderma lucidum on Escape Latency (sec) in Morris Water Maze

Treatment group	Dose	EL (Sec) Day 6	EL (Sec) Day 7	EL (Sec) Day 8	EL (Sec) Day 9
Control	10 ml/Kg	28.4 ± 2.4	14.4 ± 1.2	13.2 ± 1.1	12.4 ± 0.9
Scopolamine	0.4 mg/Kg	70.6 ± 2.5^***	71.6 ± 3.4^***	69.6 ± 4.4^***	67.6 ± 4.8^***
Physo + Scop	0.1 mg/Kg + 0.4 mg/Kg	27.4 ± 1.9	12.8 ± 0.9	11.8 ± 0.9^c	11.0 ± 0.8^c
GLE 150 mg + Scop	150 mg/Kg + 0.4 mg/Kg	29.4 ± 2.7	26.4 ± 1.8	12.8 ± 0.8	13.6 ± 0.8^c
GLE 300 mg + Scop	300 mg/Kg + 0.4 mg/Kg	27 ± 3.5	23.2 ± 2.0	10.8 ± 0.5^c**	10.0 ± 0.3^c**

Animals per group (n) = 6; The values are mean ± SEM (One-way ANOVA followed by Tukey’s Post hoc test)
^ap < 0.05, ^bp < 0.01, ^cp < 0.001 when compared with scopolamine alone treated group
*p < 0.05, **p < 0.01, ***p < 0.0001 when compared with DW treated (control) group
DW distilled water, GLE 150 Ganoderma lucidum extract (150 mg/kg), GLE 300 Ganoderma lucidum extract 300/kg, Scop Scopolamine, Physo Physostigmine