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International Journal of Phytomedicine and Phytotherapy

Table 3 Mean pharmacokinetic parameters of Qu in urine for 12 volunteers after intravenous administration of Corvitin® (average dose of anhydrous Qu was 44 mg)

From: UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration

Parameters Qu conjug Ir conjug Qu sum
Rmax (μg/h) 985.3 ± 292.5 421.8 ± 129.1 1388 ± 405
ТRmax (h) 1.63 ± 0.00 1.63 ± 0.00 1.63 ± 0.00
AURC0–t (μg) 2814 ± 969 1392 ± 520 4169 ± 1435
AURC0–∞ (ng) 2769 ± 988 1482 ± 557 4123 ± 1492
AURC0–t /AUC0–∞ (per cent) 98.98 ± 0.28 97.12 ± 3.06 99.09 ± 0.52
Ае (ng) 3164 ± 868 1548 ± 414 4643 ± 1231
Kel (R) (1/h) 0.35 ± 0.21 0.43 ± 0.15 0.35 ± 0.17
T1/2 (h) 2.60 ± 1.26 1.81 ± 0.71 2.33 ± 0.84
  1. Mean ± S.D., n = 12