International Journal of Phytomedicine and Phytotherapy
Table 3 Mean pharmacokinetic parameters of Qu in urine for 12 volunteers after intravenous administration of Corvitin® (average dose of anhydrous Qu was 44 mg)
From: UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
Parameters | Qu conjug | Ir conjug | Qu sum |
|---|---|---|---|
Rmax (μg/h) | 985.3 ± 292.5 | 421.8 ± 129.1 | 1388 ± 405 |
ТRmax (h) | 1.63 ± 0.00 | 1.63 ± 0.00 | 1.63 ± 0.00 |
AURC0–t (μg) | 2814 ± 969 | 1392 ± 520 | 4169 ± 1435 |
AURC0–∞ (ng) | 2769 ± 988 | 1482 ± 557 | 4123 ± 1492 |
AURC0–t /AUC0–∞ (per cent) | 98.98 ± 0.28 | 97.12 ± 3.06 | 99.09 ± 0.52 |
Ае (ng) | 3164 ± 868 | 1548 ± 414 | 4643 ± 1231 |
Kel (R) (1/h) | 0.35 ± 0.21 | 0.43 ± 0.15 | 0.35 ± 0.17 |
T1/2 (h) | 2.60 ± 1.26 | 1.81 ± 0.71 | 2.33 ± 0.84 |