Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of standard and MHAL and EAHAL in formalin-induced paw licking test

Group	Dose	Acute Phase		Late Phase
Group	Dose	Licking time (s)	% inhibition	Licking time (s)	% inhibition
Control	10 mL/kg	133.20 ± 6.48	0.00 ± 0.00	55.57 ± 6.35	0.00 ± 0.00
DS	100 mg/kg	65.19 ± 8.26*	51.73 ± 4.01	3.04 ± 0.26*	93.99 ± 1.24
MHAL	200 mg/kg	69.83 ± 8.29*	48.12 ± 4.05	9.77 ± 2.06*	81.54 ± 4.45
MHAL	400 mg/kg	54.91 ± 4.92*	58.77 ± 3.39	6.66 ± 1.30*	88.21 ± 1.33
EAHAL	200 mg/kg	66.60 ± 8.12*	50.47 ± 4.19	8.71 ± 1.34*	83.14 ± 3.93
EAHAL	400 mg/kg	52.37 ± 4.55*	60.63 ± 3.13	6.38 ± 1.67*	88.12 ± 2.23

Numbers of licking time inhibition are presented as (mean ± standard error of mean). MHAL = Methanol extract of Hemigraphis alternata leaves. EAHAL = Ethyl acetate extract of Hemigraphis alternata leaves. “^*푃 < 0.05, 0.01, 0.001 versus control group (Dunnett’s test)”