Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Dose-enzyme response characteristics of the influence of Annona muricata methanolic extracts on tissue amylase activity

	Dose-Response characteristics		Sigmoid plot interpolation characteristics		Hyperbola plot interpolation characteristics		Michaelis-Menten’s kinetics		Straight line regression interpolation characteristics
	LogIC50	IC50	R²	Hill’s slope	Bmax	Kd	Km	Vmax	Y-intercept	slope
Fruit-pulp	3.726	532.00	0.000	0.029	0.673	−1.11	4.25 × 10⁻¹¹	48.00	43.89	1.634
Leaf	2.469	294.60	0.826	−1.467	0.496	− 43.06	2.16 × 10⁻¹⁶	44.41	232.70	−74.80
Stem-bark	2.462	289.70	0.784	−1.344	0.489	−41.62	1.64 × 10⁻¹⁶	44.48	221.70	−70.41
Root-bark	2.756	569.80	0.702	−49.47	0.721	10.57	9.77 × 10⁻¹⁹	2.07 × 10²¹	− 117.40	67.06

Bmax = maximum binding capacity (U/L), Kd = dissociation constant (mg/dL), Km = Michaelis-Menten’s constant (mg/dL) and Vmax = maximum velocity (U/L)