Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 6 Dose-response characteristics of the influence of Annona muricata methanol extracts on α-glucosidase activity

	Dose-Response characteristics		Sigmoid plot interpolation characteristics		Hyperbola plot interpolation characteristics		Michaelis-Menten’s kinetics		Straight line regression interpolation characteristics
	LogIC50	IC50	R²	Hill’s slope	Bmax	Kd	Km	Vmax	Y-intercept	slope
Fruit-pulp	0.828	6.734	0.000	2.726	38.83	−0.030	1.176 × 10⁻¹⁶	41.59	41.67	44.23
Leaf	0.210	1.623	0.987	5.105	51.49	−0.063	1.825 × 10⁻¹⁶	60.12	60.23	58.14
Stem-bark	0.318	2.077	1.000	2.116	49.05	−0.067	1.565 × 10^− 16	57.93	57.93	55.96
Root-bark	0.812	6.483	0.000	3.002	37.76	− 0.030	1.759 × 10^− 16	40.44	40.44	43.14
Acarbose	0.236	1.722	1.000	1.481	51.17	−0.079	2.220 × 10⁻¹⁶	63.07	63.07	59.18

Bmax = maximum binding capacity (U/L), Kd = dissociation constant (mg/dL), Km = Michaelis-Menten’s constant (mg/dL) and Vmax = maximum velocity (U/L)