Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 Acute oral toxicity test (LD₅₀) of AGE

Using Lorke’s equation, LD₅₀ = √ a x b
a = nil; b = 6000 mg/kg. Therefore, the acute oral lethal dose of AGE is greater than 6000 mg/kg (Oral LD₅₀ of AGE > 6000 mg/kg). The adopted doses of AGE that were used for the main study were less than 10% of the oral LD₅₀ of AGE (> 6000 mg/kg); these include 100 mg/kg, 200 mg/kg and 400 mg/kg of AGE