Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 5 Acute oral toxicity test (LD50) of AGE

From: Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

Number of ratsDose (mg/kg)Mortality
1st PHASE
 3100/3
 31000/3
 310000/3
2nd PHASE
 27500/2
 215000/2
 230000/2
 260000/2
  1. Using Lorke’s equation, LD50 = √ a x b
  2. a = nil; b = 6000 mg/kg. Therefore, the acute oral lethal dose of AGE is greater than 6000 mg/kg (Oral LD50 of AGE > 6000 mg/kg). The adopted doses of AGE that were used for the main study were less than 10% of the oral LD50 of AGE (> 6000 mg/kg); these include 100 mg/kg, 200 mg/kg and 400 mg/kg of AGE