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International Journal of Phytomedicine and Phytotherapy

Table 10 Results of the antidiabetic activity of the total ethanol extract and the different fractions of C. myxa L. leaves using streptozotocin-induced hyperglycemia method and vildagliptin as a standard

From: Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves

Group Blood glucose level (mg/dl)
0 h 30 min 1 h 2 h 3 h 4 h 5 h
Control (−ve) 197 ± 7.21 214.33 ± 5.03 214 ± 7.81 212.67 ± 19.66 300.33 ± 2.31 309 ± 4 322.33 ± 13.01
Total extract (350 mg/kg) 209 ± 14.42 136 ± 13.45*** 108.33 ± 3.06*** 99.67 ± 1.15*** 95.67 ± 5.77*** 120 ± 1.73*** 224.33 ± 15.01***
Petroleum ether fraction (350 mg/kg) 211 ± 18.33 117 ± 7.21*** 107.67 ± 4.16*** 93.67 ± 7.57*** 87.67 ± 10.26*** 106 ± 6.08*** 237 ± 13.86**
Dichloromethane fraction (350 mg/kg) 213 ± 16.37 213 ± 11.13 163.67 ± 15.01** 121.67 ± 3.06*** 190.33 ± 1.15*** 271 ± 3.46*** 323.67 ± 2.31
Ethyl acetate fraction (350 mg/kg) 201.67 ± 3.06 205.67 ± 5.03 215 ± 4 216.33 ± 1.15 310.33 ± 1.15** 311.67 ± 8.08 312.33 ± 4.16
Butanol fraction (350 mg/kg) 204.33 ± 5.03 215 ± 5.29 221.67 ± 9.02 268 ± 29.44*** 293.33 ± 7.51 305.33 ± 3.51 327 ± 15.20
Vildagliptin (50 mg/kg) 208.67 ± 7.77 125 ± 12.12*** 102.33 ± 2.31*** 94.67 ± 6.66*** 64 ± 11.36*** 85 ± 15.20*** 178 ± 20.66***
  1. The results are presented as the mean ± S.E.M. Differences with respect to the control group were calculated using the student’s T-test (*P > 0.05, **P < 0.01, ***P < 0.001)