Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 10 Results of the antidiabetic activity of the total ethanol extract and the different fractions of C. myxa L. leaves using streptozotocin-induced hyperglycemia method and vildagliptin as a standard

Group	Blood glucose level (mg/dl)
Group	0 h	30 min	1 h	2 h	3 h	4 h	5 h
Control (−ve)	197 ± 7.21	214.33 ± 5.03	214 ± 7.81	212.67 ± 19.66	300.33 ± 2.31	309 ± 4	322.33 ± 13.01
Total extract (350 mg/kg)	209 ± 14.42	136 ± 13.45^***	108.33 ± 3.06^***	99.67 ± 1.15^***	95.67 ± 5.77^***	120 ± 1.73^***	224.33 ± 15.01^***
Petroleum ether fraction (350 mg/kg)	211 ± 18.33	117 ± 7.21^***	107.67 ± 4.16^***	93.67 ± 7.57^***	87.67 ± 10.26^***	106 ± 6.08^***	237 ± 13.86^**
Dichloromethane fraction (350 mg/kg)	213 ± 16.37	213 ± 11.13	163.67 ± 15.01^**	121.67 ± 3.06^***	190.33 ± 1.15^***	271 ± 3.46^***	323.67 ± 2.31
Ethyl acetate fraction (350 mg/kg)	201.67 ± 3.06	205.67 ± 5.03	215 ± 4	216.33 ± 1.15	310.33 ± 1.15^**	311.67 ± 8.08	312.33 ± 4.16
Butanol fraction (350 mg/kg)	204.33 ± 5.03	215 ± 5.29	221.67 ± 9.02	268 ± 29.44^***	293.33 ± 7.51	305.33 ± 3.51	327 ± 15.20
Vildagliptin (50 mg/kg)	208.67 ± 7.77	125 ± 12.12^***	102.33 ± 2.31^***	94.67 ± 6.66^***	64 ± 11.36^***	85 ± 15.20^***	178 ± 20.66^***

The results are presented as the mean ± S.E.M. Differences with respect to the control group were calculated using the student’s T-test (*P > 0.05, **P < 0.01, ***P < 0.001)