Evaluation of anti-inflammatory activity of Justicia secunda Vahl leaf extract using in vitro and in vivo inflammation models

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of methanol extract of J. secunda leaves on hematological parameters of rats induced with inflammation using formaldehyde

Parameters	Normal	Untreated control	10 mg/kg b.w. Diclofenac sodium	100 mg/kg b.w. MEJSL	300 mg/kg b.w. MEJSL
RBC (10¹²/L)	6.43 ± 0.69	6.19 ± 0.04^α	6.16 ± 0.75^α	7.09 ± 0.53^β	7.87 ± 0.10^β
HCT (%)	41.96 ± 5.84	38.30 ± 1.42^α	40.60 ± 1.13^α	42.14 ± 1.09^β	44.92 ± 1.31^β
HGB (g/dl)	13.50 ± 1.07	12.36 ± 0.94^α	12.56 ± 0.31^α	14.36 ± 0.87^β	14.66 ± 0.36 ^β
PLT (10⁹/L)	489.00 ± 67.32	339.40 ± 72.58^α	335.20 ± 83.65 ^α	527.80 ± 48.36 ^β	619.40 ± 36.44 ^β
WBC (10⁹/L)	9.22 ± 3.26	11.18 ± 0.12^Ω	9.66 ± 0.16^€	9.04 ± 0.26*	8.46 ± 1.53*
LYM (10⁹/L)	7.06 ± 2.11	8.25 ± 0.99 ^Ω	7.50 ± 1.63^€	7.40 ± 0.78*	7.10 ± 1.39*
GRAN (10⁹/L)	1.40 ± 0.85	0.74 ± 0.12 ^Ω	0.84 ± 0.21^€	0.62 ± 0.06*	0.44 ± 0.07*
EBM (10⁹/L)	0.76 ± 0.32	2.79 ± 0.10 ^Ω	1.32 ± 0.35^€	1.02 ± 0.15*	0.92 ± 0.13*

RBC red blood cells, HCT hematocrit, PLT platelet, WBC white blood cells, HGB hemoglobin, LYM lymphocytes, GRAN granulocytes, EBM eosinophil, basophil, and monocyte, MEJSL methanol extract of Justicia secunda leaves
Different symbols across row indicate significantly different at P < 0.05