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International Journal of Phytomedicine and Phytotherapy

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Table 2 Effect of combined administration of lisinopril and ethanolic extract of E. chlorantha on serum biomarkers of liver function

From: Toxicological evaluations of combined administration of ethanolic stem bark extract of Enantia chlorantha and lisinopril in experimental type 2 diabetes

GroupTreatmentAST (U/I)ALT (U/I)ALP (U/I)GGT (U/I)Total proteinTotal Bilirubin
NCDistilled water only30.36 ± 2.45a29.69 ± 0.83a1.04 ± 0.76a0.25 ± 0.84a0.79 ± 0.82d0.93 ± 0.31a
DMSTZ-fructose+ distilled water77.68 ± 4.67e85.80 ± 1.04d1.54 ± 0.54d1.14 ± 0.60d1.50 ± 0.47a2.46 ± 0.53c
T1Extract only37.10 ± 2.68ab42.60 ± 4.70b1.14 ± 0.16bc0.52 ± 0.15bc0.90 ± 0.10c1.22 ± 0.18a
T2Glucophage only44.70 ± 1.23bc39.38 ± 3.79ab1.07 ± 0.74b0.48 ± 0.03bc0.93 ± 0.29d1.14 ± 0.35a
T3Extract + Lisinopril48.70 ± 0.96c56.98 ± 1.72c1.29 ± 0.53c0.71 ± 0.26c0.78 ± 0.13b1.62 ± 0.59a
T4Glucophage + Lisinopril47.42 ± 2.03b49.12 ± 2.15bc1.26 ± 0.65c0.68 ± 0.31c0.81 ± 0.03b1.05 ± 0.44a
T5Lisinopril only60.25 ± 4.63d55.88 ± 2.07c1.39 ± 0.05d0.97 ± 0.13d1.07 ± 0.20b1.83 ± 0.34b
  1. Results are mean ± SD of seven determinations
  2. Values in the same column with similar superscripts (a, b, c or d) are not significantly (p > 0.05) different from each other