Toxicological evaluations of combined administration of ethanolic stem bark extract of Enantia chlorantha and lisinopril in experimental type 2 diabetes

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of combined administration of lisinopril and ethanolic bark extract of E. chlorantha on serum CK and LDH activities

Group	Treatment	Creatine kinase-MB	Lactate dehydrogenase activity ((U/L)
NC	Distilled water	13.57 ± 4.32^a	0.837 ± 0.82^a
DM	STZ-fructose+ distilled water	43.64 ± 5.36^b	1.878 ± 0.13^b
T1	Extract only	20.24 ± 1.89^c	1.469 ± 0.20^b
T2	Glucophage only	17.74 ± 4.74^a	1.357 ± 0.50^a,b
T3	Extract + Lisinopril	13.78 ± 3.74^a	1.135 ± 0.17^a,b
T4	Glucophage + Lisinopril	14.32 ± 0.87^a	1.075 ± 0.87^a,b
T5	Lisinopril only	16.07 ± 2.37^a	1.121 ± 0.83^a,b

Results are mean ± SD of seven determinations
Values in the same column with similar superscripts (a, b or c) are not significantly (p > 0.05) different from each other