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International Journal of Phytomedicine and Phytotherapy

Table 2 The sedative effect of MESC on the open field test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment Dose (mg/kg)   Number of squares crossed  
0 min. 30 mins. 60 mins. 90 mins. 120 mins.
Control 0.1 ml/mouse 106.20 ± 0. 93 106.60 ± 0.66 102.40 ± 0.97 100.40 ± 1.02 98.00 ± 1.14
Diazepam 1 100.80 ± 0.60 43.80 ± 1.07* 24.40 ± 0.81* 13.80 ± 0.80* 5.20 ± 0.37*
MESC 200 103.00 ± 0.70 88.60 ± 0.51* 64.60 ± 0.95* 43.00 ± 1.52* 20.80 ± 1.57*
MESC 400 101.80 ± 0.86 52.20 ± 1.06* 30.00 ± 0.70* 18.80 ± 0.58 * 9.40 ± 0.51*
MESC 600 98.80 ± 0.58 44.20 ± 0.91* 25.60 ± 1.02* 16.00 ± 0.70* 7.20 ± 0.48*
  1. i.* p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group