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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 The sedative effect of MESC on the open field test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment

Dose (mg/kg)

 

Number of squares crossed

 

0 min.

30 mins.

60 mins.

90 mins.

120 mins.

Control

0.1 ml/mouse

106.20 ± 0. 93

106.60 ± 0.66

102.40 ± 0.97

100.40 ± 1.02

98.00 ± 1.14

Diazepam

1

100.80 ± 0.60

43.80 ± 1.07*

24.40 ± 0.81*

13.80 ± 0.80*

5.20 ± 0.37*

MESC

200

103.00 ± 0.70

88.60 ± 0.51*

64.60 ± 0.95*

43.00 ± 1.52*

20.80 ± 1.57*

MESC

400

101.80 ± 0.86

52.20 ± 1.06*

30.00 ± 0.70*

18.80 ± 0.58 *

9.40 ± 0.51*

MESC

600

98.80 ± 0.58

44.20 ± 0.91*

25.60 ± 1.02*

16.00 ± 0.70*

7.20 ± 0.48*

  1. i.* p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group
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