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International Journal of Phytomedicine and Phytotherapy

Table 4 The anxiolytic effect of MESC on elevated plus-maze test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment Dose (mg/kg) Time spent in open arms (s) Time spent in close arms (s) Entries in open arms (s) Entries in closed arms (s) Total no. of entries
Control 0.1 ml/mouse 113 ± 0.83
(37.33)
187 ± 0.24
(29.67)
8 ± 0.83
(62.67)
16 ± 0.70
(70.31)
26
Diazepam 1 250.60 ± 0.92**
(85.53)
49.40 ± 0.93**
(16.47)
18.20 ± 0.37**
(88.35)
2.40 ± 0.40**
(11.65)
21
MESC 200 160.60 ± 1.88**
(53.53)
139.40 ± 0.54**
(30.63)
6.80 ± 1.88*
(46.47)
15.40 ± 0.34*
(69.37)
22
MESC 400 175.20 ± 0.86**
(58.40)
124.80 ± 0.86**
(62.50)
12.00 ± 0.37**
(41.60)
7.20 ± 0.25**
(37.50)
19
MESC 600 187.00 ± 2.02**
(62.33)
113.00 ± 2.02**
(74.74)
14.20 ± 0.58**
(37.67)
4.80 ± 037**
(25.26)
19
  1. i. * p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group
  3. # within bracket result expressed in percentage (%).