International Journal of Phytomedicine and Phytotherapy
Table 4 The anxiolytic effect of MESC on elevated plus-maze test in mice
Treatment | Dose (mg/kg) | Time spent in open arms (s) | Time spent in close arms (s) | Entries in open arms (s) | Entries in closed arms (s) | Total no. of entries |
|---|---|---|---|---|---|---|
Control | 0.1 ml/mouse | 113 ± 0.83 (37.33) | 187 ± 0.24 (29.67) | 8 ± 0.83 (62.67) | 16 ± 0.70 (70.31) | 26 |
Diazepam | 1 | 250.60 ± 0.92** (85.53) | 49.40 ± 0.93** (16.47) | 18.20 ± 0.37** (88.35) | 2.40 ± 0.40** (11.65) | 21 |
MESC | 200 | 160.60 ± 1.88** (53.53) | 139.40 ± 0.54** (30.63) | 6.80 ± 1.88* (46.47) | 15.40 ± 0.34* (69.37) | 22 |
MESC | 400 | 175.20 ± 0.86** (58.40) | 124.80 ± 0.86** (62.50) | 12.00 ± 0.37** (41.60) | 7.20 ± 0.25** (37.50) | 19 |
MESC | 600 | 187.00 ± 2.02** (62.33) | 113.00 ± 2.02** (74.74) | 14.20 ± 0.58** (37.67) | 4.80 ± 037** (25.26) | 19 |