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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Pharmacokinetic parameter of K007 and K008 after single oral dose of FDSE (250 mg.kg− 1) in SD rats

From: Self-emulsifying formulation of Spinacia oleracea reduces the dose and escalates bioavailability of bioactive compounds to accelerate fracture repair in rats

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Parameters

K007

K008

Cmax (ng/mL)

7.6

5.0

tmax (h)

1.4

2

AUClast (ng h/mL)

39.0

23.3

AUC0-∞(ng h/mL)

49.3

35.3

MRT (h)

3.4

3.9

Cl/F (L/h/kg)

12.8

1.4

Vss/F (L/kg)

43.3

5.6

  1. Abbreviations: AUClast = area under the serum concentration-time curve up to last observation, Cmax = peak serum concentration, tmax = time to Cmax, MRT = mean residence time, Vss/F = steady-state volume of distribution, Cl/F = clearance, F = fraction of dose absorbed
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