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International Journal of Phytomedicine and Phytotherapy

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Table 3 Drug-likeness properties of phytochemicals of R. tetraphylla and O. indicum based on Lipinski’s rule and SwissADME

From: Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach

Compounds PubChem
ID
Mol. weight
(< 500 Da)
LogP (< 5) H-bond donor
(< 5)
H-bond acceptor (< 10) BS TPSA
Acarbose 41,774 645.6 −8.5 14 19 0.17 321 Å2
R1 91,723,645 459.6 2.3 1 6 0.55 120 Å2
R2 17,169 260.67 2.6 2 3 0.56 57.5 Å2
R3 6,422,266 199.17 −0.8 2 5 0.55 119 Å2
R4 602,121 225.28 3.1 0 1 0.55 14.2 Å2
O1 535,099 156.29 3.1 0 1 0.55 25.3 Å2
O2 609,707 303.15 3 2 2 0.55 48.9 Å2
O3 634,947 442.60 7.8 0 2 0.55 24.7 Å2
O4 635,787 521.78 3.2 2 3 0.55 69.6 Å2
O5 5,363,717 219.40 1.9 1 3 0.55 86.5 Å2
O6 22,213,249 330.50 2.8 0 3 0.55 51.2 Å2
O7 521,987 252.40 2.2 0 6 0.55 103 Å2
  1. BS – bioavailability score, TPSA – Topological Polar Surface Area