|Study||Study design||Population||Sample size||Main findings|
|Tesche S, et al. 2008 ||Double-blind randomized clinical trial||Patients suspected of having acute rhinosinusitis||
n = 75 with 5-component herbal preparation|
n = 75 with cineole
The change in symptom-sum score from baseline to Day 7 was higher in the cineole group (− 11.0 ± 3.3) than in the other group (− 8.0 ± 3.0) (p < 0.0001).
Changes in individual components of symptom-sum score were higher in the cineole group than in the other group.
|Gottschlich S, et al. 2018 ||Non-interventional study||Patients with a recommendation for treatment with GeloMyrtol or Sinupret and with a diagnosis of acute rhinosinusitis based on EPOS guidelines||
n = 117 with GeloMyrtol|
n = 111 with Sinupret (BNO 1016)
|Overall, GeloMyrtol and Sinupret had comparable effectiveness. The study presents with methodological flaws.|