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International Journal of Phytomedicine and Phytotherapy

Table 2 Predicted Absorption of seven Ligands

From: In-Vitro antioxidant, anti-lipid peroxidative activities and In-Silico study of Terminalia chebula bioactive compounds

  Caffeic acid Catechin Ellagic acid Epicatechin Gallic acid Quercetin Rutin
Blood-Brain Barrier BBB- BBB- BBB+ BBB- BBB- BBB- BBB-
Human Intestinal Absorption HIA+ HIA+ HIA+ HIA+ HIA+ HIA+ HIA+
Caco-2 Permeability Caco2+ Caco2- Caco2- Caco2- Caco2- Caco2- Caco2-
P-glycoprotein Substrate Non-substrate Substrate Substrate Substrate Non-substrate Substrate Substrate
P-glycoprotein Inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor
Renal Organic Cation Transporter Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor