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International Journal of Phytomedicine and Phytotherapy

Table 4 In vitro inhibitory effects of different solvent fractions of P.guineense on the activity of dipeptidyl peptidase –IV (DPP-IV)

From: In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense)

Fraction Concentration (mg/ml) % Inhibition ± SEM IC50 (mg/ml) ± SEM
AQUEOUS 5.00 49.06 ± 0.40 4.60 ± 0.87
2.50 45.28 ± 1.47
1.25 35.85 ± 1.08
0.625 20.75 ± 0.29
0.3125 4.72 ± 0.18
0.15625 1.52 ± 0.10
BUTANOL 5.00 54.38 ± 0.10 3.22 ± 0.03
2.50 49.70 ± 2.56
1.25 40.75 ± 0.18
0.625 35.36 ± 0.96
0.3125 17.54 ± 0.28
0.15625 4.65 ± 0.10
DCM 5.00 73.70 ± 2.50 1.83 ± 0.35
2.50 50.96 ± 1.80
1.25 48.49 ± 1.09
0.625 48.19 ± 0.06
0.3125 45.12 ± 0.20
0.15625 10.38 ± 1.40
ETHYL ACETATE 5.00 58.50 ± 0.05 1.45 ± 0.12
2.50 55.35 ± 0.40
1.25 51.05 ± 0.38
0.625 46.02 ± 0.20
0.3125 43.31 ± 0.60
0.15625 18.67 ± 0.84
VIDAGLIPTIN 5.00 8.95 ± 0.10 0.07 ± 0.01
2.50 16.09 ± 3.20
1.25 38.50 ± 0.20
0.625 48.60 ± 2.55
0.3125 60.50 ± 1.08
0.15625 69.05 ± 0.20