International Journal of Phytomedicine and Phytotherapy
Table 4 In vitro inhibitory effects of different solvent fractions of P.guineense on the activity of dipeptidyl peptidase –IV (DPP-IV)
Fraction | Concentration (mg/ml) | % Inhibition ± SEM | IC50 (mg/ml) ± SEM |
|---|---|---|---|
AQUEOUS | 5.00 | 49.06 ± 0.40 | 4.60 ± 0.87 |
2.50 | 45.28 ± 1.47 | ||
1.25 | 35.85 ± 1.08 | ||
0.625 | 20.75 ± 0.29 | ||
0.3125 | 4.72 ± 0.18 | ||
0.15625 | 1.52 ± 0.10 | ||
BUTANOL | 5.00 | 54.38 ± 0.10 | 3.22 ± 0.03 |
2.50 | 49.70 ± 2.56 | ||
1.25 | 40.75 ± 0.18 | ||
0.625 | 35.36 ± 0.96 | ||
0.3125 | 17.54 ± 0.28 | ||
0.15625 | 4.65 ± 0.10 | ||
DCM | 5.00 | 73.70 ± 2.50 | 1.83 ± 0.35 |
2.50 | 50.96 ± 1.80 | ||
1.25 | 48.49 ± 1.09 | ||
0.625 | 48.19 ± 0.06 | ||
0.3125 | 45.12 ± 0.20 | ||
0.15625 | 10.38 ± 1.40 | ||
ETHYL ACETATE | 5.00 | 58.50 ± 0.05 | 1.45 ± 0.12 |
2.50 | 55.35 ± 0.40 | ||
1.25 | 51.05 ± 0.38 | ||
0.625 | 46.02 ± 0.20 | ||
0.3125 | 43.31 ± 0.60 | ||
0.15625 | 18.67 ± 0.84 | ||
VIDAGLIPTIN | 5.00 | 8.95 ± 0.10 | 0.07 ± 0.01 |
2.50 | 16.09 ± 3.20 | ||
1.25 | 38.50 ± 0.20 | ||
0.625 | 48.60 ± 2.55 | ||
0.3125 | 60.50 ± 1.08 | ||
0.15625 | 69.05 ± 0.20 |