International Journal of Phytomedicine and Phytotherapy
Table 2 Summary of studies on herbal-antimalarial drugs interactions using P. berghei and P. yoelii nigerense model
From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs
S/no | Medicinal plant | Conventional antimalarial drug | Interaction effect | Reference |
|---|---|---|---|---|
12 | Aqueous leaf extract of TO (200 mg/kg) | ART (2 mg/kg) | Synergistic effect | [16] |
13 | VA (100–500 mg/kg) | AQ (2–10 mg/kg) and ART (0.8–4 mg/kg) | Synergistic effect | [3] |
14 | Aqueous leaf extract of Ageratum conyzoides (100 mg/kg) | CQ (5 mg/kg), ART | Extract potentiated activities of CQ and ART | [32] |
15 | MAMA herbal antimalarial decoction (120 mg/kg) | AQ (10 mg/kg) | Synergistic effect against CQ sensitive (except resistant) | [33] |
16 | Methanol leaf extract Uvaria chamae (100–400 mg/kg) | AQ (10 mg/kg) | Low dose of extract + AQ produced better antimalarial activity | [34] |
17 | Aqueous leaf extract of VA (31.25, 62.5, 125 mg/kg) | CQ (5 mg/kg) | Extract ↑ antimalarial effects of CQ | [15] |
18 | Ethanol stem bark extract of Khaya grandifolia (50–400 mg/kg) | CQ (2.5 mg/kg) Halofantrine, 6.25 mg/kg) | Enhanced antiplasmodial activity and mean survival time | [11] |