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International Journal of Phytomedicine and Phytotherapy

Table 2 Summary of studies on herbal-antimalarial drugs interactions using P. berghei and P. yoelii nigerense model

From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

S/no Medicinal plant Conventional antimalarial drug Interaction effect Reference
12 Aqueous leaf extract of TO (200 mg/kg) ART (2 mg/kg) Synergistic effect [16]
13 VA (100–500 mg/kg) AQ (2–10 mg/kg) and ART (0.8–4 mg/kg) Synergistic effect [3]
14 Aqueous leaf extract of Ageratum conyzoides (100 mg/kg) CQ (5 mg/kg), ART Extract potentiated activities of CQ and ART [32]
15 MAMA herbal antimalarial decoction (120 mg/kg) AQ (10 mg/kg) Synergistic effect against CQ sensitive (except resistant) [33]
16 Methanol leaf extract Uvaria chamae (100–400 mg/kg) AQ (10 mg/kg) Low dose of extract + AQ produced better antimalarial activity [34]
17 Aqueous leaf extract of VA (31.25, 62.5, 125 mg/kg) CQ (5 mg/kg) Extract ↑ antimalarial effects of CQ [15]
18 Ethanol stem bark extract of Khaya grandifolia (50–400 mg/kg) CQ (2.5 mg/kg)
Halofantrine, 6.25 mg/kg)
Enhanced antiplasmodial activity and mean survival time [11]
  1. Vernonia amygdalina (VA); Artesunate (ART); Plasmodium berghei (P. berghei); Chloroquine (CQ). Amodiaquine (AQ). ↑ (Increased activity)