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International Journal of Phytomedicine and Phytotherapy

Table 4 Liver function test of rats subjected to short, medium and long term oral administration of extracts of four ethnomedicinal plants

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Group

Type of toxicity study

ALT (U/I)

AST (U/I)

ALP (U/I)

TP (g/dL)

Albumin (g/dL)

Globulin (g/dL)

Anogeissus leiocarpus

Acute

52.57±1.38a

69.69±2.56a

157.8±3.25a

7.58±0.15a

4.18±0.12

4.03±0.21

Sub-acute

41.36±1.53b

53.01±5.36b

126.6±3.50b

10.17±0.45b

4.71±0.39

4.06±0.09

Sub-chronic

43.85±2.08

48.74±1.20b

127.1±3.30b

9.83±0.30b

6.82±0.15

4.36±0.12

Chronic

43.72±3.34

50.69±0.86b

125.7±5.21b

9.7±0.43b

4.55±0.14

4.23±0.43

Azadirachta indica

Acute

43.27±2.68

54.97±5.17

128.2±3.85

10.28±0.14

5.37±0.09

4.64±0.22

Sub-acute

40.8±4.63

50.18±4.28

125.2±6.19

9.89±0.30

4.87±0.08

3.96±0.18b

Sub-chronic

40.94±3.48

49.33±1.84

128.4±1.98

9.84±0.44

5.29±0.1

4.41±0.19

Chronic

42.04±4.01

55.78±4.28

125.7±4.90

9.89±0.25

5.09±0.22

5.02±0.22a

Tamarindus indica

Acute

40.1±2.93

50.73±1.3.82

123.94±5.43

8.66±0.26

4.84±0.14

4.36±0.21

Sub-acute

42.31±3.74

47.51±4.90

129.11±5.10

9.93±0.41

5.91±0.12

4.82±0.25

Sub-chronic

46.97±7.09

56.9±3.83

126.9±1.95

10.91±0.27

6.01±0.45

5.41±0.41

Chronic

37.94±4.11

61.22±5.71a

130±3.74

10.33±0.35

5.77±0.35

5.05±0.27

Khaya senegalensis

Acute

57.87±3.38a,x

55.66±4.24

152.9±3.52a,x

7.57±0.14a

3.94±0.24

3.96±0.14

Sub-acute

54.95±3.35a,x

49.81±3.82b

125±5.55b

8.36±0.23

4.12±0.37

4.29±0.26

Sub-chronic

64.06±2.39a

57.01±4.54

156.6±4.14a,x

8.03±0.45

4.02±0.20

3.56±0.30a

Chronic

70.25±2.84a,y

68.64±1.57a

191.7±2.99a,y

8.06±0.27

4.4±0.49

4.2±0.12

Distilled water

 

39.53±2.73b

49.31±3.79b

126.3±2.42b

10.06±0.19b

5.25±0.14

4.72±0.17

  1. a and b = significant difference between each group and control (distilled water) group; while x and y = significant different within each group