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International Journal of Phytomedicine and Phytotherapy

Table 4 Liver function test of rats subjected to short, medium and long term oral administration of extracts of four ethnomedicinal plants

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Group Type of toxicity study ALT (U/I) AST (U/I) ALP (U/I) TP (g/dL) Albumin (g/dL) Globulin (g/dL)
Anogeissus leiocarpus Acute 52.57±1.38a 69.69±2.56a 157.8±3.25a 7.58±0.15a 4.18±0.12 4.03±0.21
Sub-acute 41.36±1.53b 53.01±5.36b 126.6±3.50b 10.17±0.45b 4.71±0.39 4.06±0.09
Sub-chronic 43.85±2.08 48.74±1.20b 127.1±3.30b 9.83±0.30b 6.82±0.15 4.36±0.12
Chronic 43.72±3.34 50.69±0.86b 125.7±5.21b 9.7±0.43b 4.55±0.14 4.23±0.43
Azadirachta indica Acute 43.27±2.68 54.97±5.17 128.2±3.85 10.28±0.14 5.37±0.09 4.64±0.22
Sub-acute 40.8±4.63 50.18±4.28 125.2±6.19 9.89±0.30 4.87±0.08 3.96±0.18b
Sub-chronic 40.94±3.48 49.33±1.84 128.4±1.98 9.84±0.44 5.29±0.1 4.41±0.19
Chronic 42.04±4.01 55.78±4.28 125.7±4.90 9.89±0.25 5.09±0.22 5.02±0.22a
Tamarindus indica Acute 40.1±2.93 50.73±1.3.82 123.94±5.43 8.66±0.26 4.84±0.14 4.36±0.21
Sub-acute 42.31±3.74 47.51±4.90 129.11±5.10 9.93±0.41 5.91±0.12 4.82±0.25
Sub-chronic 46.97±7.09 56.9±3.83 126.9±1.95 10.91±0.27 6.01±0.45 5.41±0.41
Chronic 37.94±4.11 61.22±5.71a 130±3.74 10.33±0.35 5.77±0.35 5.05±0.27
Khaya senegalensis Acute 57.87±3.38a,x 55.66±4.24 152.9±3.52a,x 7.57±0.14a 3.94±0.24 3.96±0.14
Sub-acute 54.95±3.35a,x 49.81±3.82b 125±5.55b 8.36±0.23 4.12±0.37 4.29±0.26
Sub-chronic 64.06±2.39a 57.01±4.54 156.6±4.14a,x 8.03±0.45 4.02±0.20 3.56±0.30a
Chronic 70.25±2.84a,y 68.64±1.57a 191.7±2.99a,y 8.06±0.27 4.4±0.49 4.2±0.12
Distilled water   39.53±2.73b 49.31±3.79b 126.3±2.42b 10.06±0.19b 5.25±0.14 4.72±0.17
  1. a and b = significant difference between each group and control (distilled water) group; while x and y = significant different within each group