Toxicological evaluation of the dried hydroethanolic extract of Amaranthus spinosus L. roots in Artemia salina larvae and Sprague Dawley rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of A. spinosus on biochemical parameters in female rats

Parameters	Control	*A. spinosus* 500 mg/kg/day	*A. spinosus* 1000 mg/kg/day
Urea (g/L)	0.439 ±0.030	0.404 ± 0.030	0.390 ± 0.037
Creatinine (mg/L)	6.741 ± 0.692	7.980 ± 0.377	7.740 ± 0.060
CPK (IU/L)	331.867 ± 44.377	282.043 ± 40.296	272.058 ± 44.822
ASAT (IU/L)	160.011 ± 14.493	134.600 ± 6.071	135.400 ± 7.960
ALAT (IU/L)	50.796 ± 5.573	43.200 ± 3.734	46.200 ± 6.224
ɣ-GT (IU/L)	9.600 ± 1.400	8.000 ± 0.707	8.400 ± 0.678
TG (g/L)	0.732 ± 0.077	0.650 ± 0.070	0.748 ± 0.042
TC (g/L)	0.790 ± 0.040	0.680 ± 0.024	0.646 ± 0.038*
HDL-C (g/L)	0.492 ± 0.060	0.454 ± 0.045	0.470 ± 0.013
LDL-C (g/L)	0.192 ± 0.051	0.122 ± 0.046	0.056 ± 0.033*

CPK = creatinine phosphokinase; ASAT = aspartate aminotransferase; ALAT = alanine aminotransferase; ɣ-GT = ɣ-glutamyltranspeptidase; TG = triglycerides; Total-C = total cholesterol; HDL and LDL-C = high and Low-density lipoprotein cholesterol. The values were analysed with 1-way ANOVA and expressed as the mean ± SEM, then compared to the control. *p < 0.05. n = 5