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International Journal of Phytomedicine and Phytotherapy

Table 4 Comparison of the groups by the dynamics of the main symptoms severity according to the physician’s assessment (% of the Mann-Whitney U test)

From: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19

Indicator

Day

Main group %

Control group %

Mann–Whitney U test

Wilcoxon’s test W

Statistics Z

p-value

Differences significance*

Hyperthermia

V1

100

100

1096.00

2224.00

-0.420

0.675

Non-significant

V2–V1

-41.4

-7.3

765.50

1990.50

-2.979

0.003

Significant

V3–V1

-98.0

-89.5

1003.00

2228.00

-1.124

0.261

Non-significant

Myalgia

V1

100

100

1003.00

2131.00

-1.127

0.260

Non-significant

V2–V1

-24.5

6.1

586.00

1811.00

-4.471

0.000

Significant

V3–V1

-97.1

-67.6

697.00

1922.00

-3.415

0.001

Significant

Nasal congestion

V1

100

100

1455.00

3285.00

-1.854

0.064

Non-significant

V2–V1

-17.4

27.2

644.50

1869.50

-4.009

0.000

Significant

V3–V1

-95.4

-65.4

714.00

1939.00

-3.274

0.001

Significant

Nasal discharge

V1

100

100

959.50

2184.50

-1.539

0.124

Non-significant

V2–V1

-25.5

-29.7

1062.50

2190.50

-0.743

0.457

Non-significant

V3–V1

-92.7

-85.7

999.00

2127.00

-1.223

0.221

Non-significant

Coughing

V1

100

100

862.00

2087.00

-1.127

0.215

Non-significant

V2–V1

43.9

28.1

1126.50

2351.50

-0.203

0.839

Non-significant

V3–V1

-100.0

-51.0

1083.00

2211.00

-2.560

0.005

Significant

Anosmia

V1

100

100

1129.00

2354.00

-0.192

0.848

Non-significant

V2–V1

170.0

177.2

1121.50

2346.50

-0.226

0.821

Non-significant

V3–V1

-11.3

74.7

952.00

2177.00

-3.498

0.000

Significant

Rhinolalia

V1

100

100

1147.00

2372.00

-0.034

0.973

Non-significant

V2–V1

-13.1

23.0

946.00

2171.00

-1.985

0.004

Significant

V3–V1

-90.2

-65.1

1021.00

2246.00

-0.994

0.320

Non-significant

Sore throat

V1

100

100

1113.00

2241.00

-0.294

0.769

Non-significant

V2–V1

-51.6

-34.7

973.00

2198.00

-1.457

0.145

Non-significant

V3–V1

-100.0

-90.9

1049.50

2274.50

-0.780

0.435

Non-significant

  1. *The conclusion has been made at a significance level of 0.05