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International Journal of Phytomedicine and Phytotherapy

Table 4 Comparison of the groups by the dynamics of the main symptoms severity according to the physician’s assessment (% of the Mann-Whitney U test)

From: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19

Indicator Day Main group % Control group % Mann–Whitney U test Wilcoxon’s test W Statistics Z p-value Differences significance*
Hyperthermia V1 100 100 1096.00 2224.00 -0.420 0.675 Non-significant
V2–V1 -41.4 -7.3 765.50 1990.50 -2.979 0.003 Significant
V3–V1 -98.0 -89.5 1003.00 2228.00 -1.124 0.261 Non-significant
Myalgia V1 100 100 1003.00 2131.00 -1.127 0.260 Non-significant
V2–V1 -24.5 6.1 586.00 1811.00 -4.471 0.000 Significant
V3–V1 -97.1 -67.6 697.00 1922.00 -3.415 0.001 Significant
Nasal congestion V1 100 100 1455.00 3285.00 -1.854 0.064 Non-significant
V2–V1 -17.4 27.2 644.50 1869.50 -4.009 0.000 Significant
V3–V1 -95.4 -65.4 714.00 1939.00 -3.274 0.001 Significant
Nasal discharge V1 100 100 959.50 2184.50 -1.539 0.124 Non-significant
V2–V1 -25.5 -29.7 1062.50 2190.50 -0.743 0.457 Non-significant
V3–V1 -92.7 -85.7 999.00 2127.00 -1.223 0.221 Non-significant
Coughing V1 100 100 862.00 2087.00 -1.127 0.215 Non-significant
V2–V1 43.9 28.1 1126.50 2351.50 -0.203 0.839 Non-significant
V3–V1 -100.0 -51.0 1083.00 2211.00 -2.560 0.005 Significant
Anosmia V1 100 100 1129.00 2354.00 -0.192 0.848 Non-significant
V2–V1 170.0 177.2 1121.50 2346.50 -0.226 0.821 Non-significant
V3–V1 -11.3 74.7 952.00 2177.00 -3.498 0.000 Significant
Rhinolalia V1 100 100 1147.00 2372.00 -0.034 0.973 Non-significant
V2–V1 -13.1 23.0 946.00 2171.00 -1.985 0.004 Significant
V3–V1 -90.2 -65.1 1021.00 2246.00 -0.994 0.320 Non-significant
Sore throat V1 100 100 1113.00 2241.00 -0.294 0.769 Non-significant
V2–V1 -51.6 -34.7 973.00 2198.00 -1.457 0.145 Non-significant
V3–V1 -100.0 -90.9 1049.50 2274.50 -0.780 0.435 Non-significant
  1. *The conclusion has been made at a significance level of 0.05