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International Journal of Phytomedicine and Phytotherapy

Table 8 Effect of AKSS16-LIV01 onliver Lipid peroxidation, NO, iNOS levels and Hydroxyproline concentration in chronic ethanol-induced hepatic damage in mice

From: Antioxidant and immunomodulatory effect of AKSS16-LIV01 – a multi herbal formulation against ethanol induced liver dysfunction in mice

Parameters Normal Ethanol Ethanol + AKSS16-LIV01 (75) Ethanol+AKSS16-LIV01 (150) Ethanol+AKSS16-LIV01 (300) Ethanol +Silymarin(100) AKSS16-LIV01 (300)
Lipid Peroxidation (nm/100 g tissue) 68.16 ± 3.52 182.16 ± 3.09 92.35 ± 2.14* 77.92 ± 1.47* 62.58 ± 2.52** 82.57 ± 1.67* 66.57 ± 0.99*
NO (μmol/mg protein) 0.64 ± 0.004 2.29 ± 0.002# 102.77 ± 0.005* 0.84 ± 0.004* 0.69 ± 0.006** 0.88 ± 0.007* 0.65 ± 0.002*
iNOS (U/mg protein) 0.32 ± 0.003 1.11 ± 0.002# 0.62 ± 0.005* 0.46 ± 0.006* 0.38 ± 0.003** 0.45 ± 0.005* 0.39 ± 0.003*
Hydroxyproline (mq/g) 0.42 ± 0.004 0.99 ± 0.004# 0.76 ± 0.006* 0.55 ± 0.003* 0.47 ± 0.002** 0.56 ± 0.004* 0.44 ± 0.005*
  1. The values are expressed as the mean ± SEM. Significantly different from control #p < 0.001 and significantly different from ethanol*p < 0.05, **p < 0.001using analysis of variance (ANOVA) followed by Dunnettʼs Multiple Comparison Test