Cardioprotective effects of Rhododendron arboreum leaf extract against Doxorubicin-induced cardiotoxicity in Wistar rats by modulating electrocardiographic and cardiac biomarkers

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of Rhododendron arboreum leaf extract on various parameters of ECG of Wistar rats (N-6)

SL.NO	Treatments groups	Heart Rate (BPM)	QRS Interval (ms)	RR Interval (ms)	QT Interval (ms)	PR Interval (ms)
1.	Normal control	336.6 ± 1.65	13.82 ± 0.16	177.7 ± 0.14	44.74 ± 0.10	32.49 ± 0.11
2.	DOX control	458.4 ± 4.18^***	27.91 ± 0.62^***	134.8 ± 1.01^***	82.29 ± 3.05^***	49.17 ± 0.68^***
3.	RALD- 100 mg/kg	407.4 ± 1.79^***###	22.51 ± 1.60^***##	148.1 ± 0.70^***###	71.08 ± 2.06^***##	41.16 ± 0.26^***###
4.	RAHD- 250 mg/kg	383.1 ± 1.66^***###	17.60 ± 0.17^*###	153.5 ± 0.76^***###	56.34 ± 1.39^**###	37.49 ± 0.78^***###

Values are expressed as mean ± SEM, n = 6, ^***P < 0.001, ^**P < 0.01, ^*P < 0.05, when compared to normal group; ^###P < 0.001,^##P < 0.01, when compared to DOX control group
DOX Doxorubicin, RALD Rhododendron arboreum low dose, RAHD Rhododendron arboreum high dose