International Journal of Phytomedicine and Phytotherapy
Study | Plant | Animal type and model | Extraction method/ component | Duration of treatment | % Difference From negative Control | % Difference From standard control |
---|---|---|---|---|---|---|
(Abebaw, Mishra et al. 2017) [1] | Osyris quadripartita Decne.(Santalaceae) | Pylorus ligation induced Wistar albino rats | Methanol | 20 days | 200 mg/kg = 68.42 | 200 mg/kg = 1.5% |
Ethanol-induced ulcer models Wistar albino rats |  | 20 days | 200 mg/kg = 85.35 | 200 mg/kg = −4.1% | ||
(Adane, Atnafie et al. 2021) [2] | Ficus thonningii (Moraceae) | Pylorus ligation | Hydromethanol | 10 days | 100 mg/kg = 33.6 200 mg/kg = 59.07 400 mg/kg = 62.1 | 100 mg/kg = −14.7 200 mg/kg = 10.57 400 mg/kg = 13.6 |
Ethanol-induced ulcer rodent models | Hydromethanol | 10 days | 100 mg/kg = 71.86 | 100 mg/kg = −1.1 | ||
Chloroform fraction | 10 days | 200 mg/kg = 39.16 | 200 mg/kg = −33.2 | |||
Aqueous fraction | 10 days | 200 mg/kg = 70.76 | 200 mg/kg = −2.2 | |||
Indomethacin induced | Hydromethanol | 4 days | 100 mg/kg = 55.02 200 mg/kg = 61.15 400 mg/kg = 63.35 | 100 mg/kg = − 44.98 200 mg/kg = − 38.85 400 mg/kg = − 36.65 | ||
(Belayneh, Amare et al. 2021) [9] | Solanum incanum L. (Solanaceae) | Pylorus ligation-induced model | Hydromethanol | 10 days | Leaf 100 mg/kg = 5.83 200 mg/kg = 34.17 400 mg/kg = 48.83 Root 100 mg/kg = 27.83 200 mg/kg = 30.5 400 mg/kg = 48.67 | Leaf 100 mg/kg = − 48.67 200 mg/kg = − 20.33 400 mg/kg = − 5.67 Root 100 mg/kg = − 26.6 200 mg/kg = − 24 400 mg/kg = − 5.83 |
Ethanol-induced Mice ulcer | Hydromethanol | 10 days | Leaf 100 mg/kg = 35.43 200 mg/kg = 44.88 400 mg/kg = 52.36 Root 100 mg/kg = 36.02 200 mg/kg = 42.32 400 mg/kg = 52.36 | Leaf 100 mg/kg = − 37.4 200 mg/kg = − 27.95 400 mg/kg = − 20.47 Root 100 mg/kg = − 36.81 200 mg/kg = − 30.51 400 mg/kg = − 20.47 | ||
(Mekonnen, Asrade Atnafie et al. 2020) [27] | Crotonmacrostachyus Hocsht:Ex Del. (Euphorbiaceae) | Acidified Ethanol-induced Mice ulcer | Methanol | 7 days | 100 mg/kg = 24.44 200 mg/kg = 45.93 400 mg/kg = 62.22 | 100 mg/kg = − 55.56 200 mg/kg = − 34.07 400 mg/kg = − 17.78 |
Chloroform | 7 days | 100 mg/kg = 53 200 mg/kg = 68.8 400 mg/kg = 78.1 | 100 mg/kg = − 28.4 200 mg/kg = − 12.6 400 mg/kg = − 3.3 | |||
Ethyl acetate fraction | 7 days | 100 mg/kg = 18.6 200 mg/kg = 46.6 400 mg/kg = 62.8 | 100 mg/kg = − 62.8 200 mg/kg = − 34.8 400 mg/kg = − 18.8 | |||
Aqueous fraction | 7 days | 100 mg/kg = 11.7 200 mg/kg = 11.32 400 mg/kg = 21.4 | 100 mg/kg = − 69.7 200 mg/kg = − 70.08 400 mg/kg = − 60 | |||
(Melese, Asres et al. 2011) [28] | Plantago lanceolata L | Indomethacin induced | aqueous extract | 4 hrs | 200 mg/kg = 27.3 400 mg/kg = 86.4 | 200 mg/kg = − 40.9 400 mg/kg = 18.2 |
cysteamine induced | aqueous extract | 24 hrs | 200 mg/kg = 40 400 mg/kg = 60 | 200 mg/kg = − 33.3 400 mg/kg = − 13.3 | ||
Acetic acid-induced | Aqueous extract | 10 days | 200 mg/kg = 50.9 400 mg/kg = 77.9 | 200 mg/kg = − 25.3 400 mg/kg = 1.7 | ||
Mequanente, Makonnen et al. 2006 [29] | Trigonella feonum-gracum | Indomethacin-induced | Aqueous extract | 6 hrs | 500 mg/kg = 33.6 1000 mg/kg = 59.9 1500 mg/kg = 65.5 | 500 mg/kg = − 20.8 1000 mg/kg = 5.5 1500 mg/kg = 11.1 |
Linum ussitatissimum | Indomethacin-induced | Aqueous extract | 6 hrs | 500 mg/kg = 42 1000 mg/kg = 58.6 1500 mg/kg = 67.8 | 500 mg/kg = − 12.4 1000 mg/kg = 4.2 1500 mg/kg = 13.4 | |
(Noamesi, Mensah et al. 1994) [35] | Taverniera abyssinica A. | Ethanol induced | Aqueous extract | 4 days | 125 mg/kg = 54 250 mg/kg = 58 500 mg/kg = 80 |  |
(Sisay, Andargie et al. 2021) [44] | Urtica simensis Hochst. ex. A. Rich. (Urticaceae) | pylorus-ligated rats. | Hydromethanolic | 10 days | 100 mg/kg = 50.34 200 mg/kg = 59.88 400 mg/kg = 67.68 | 100 mg/kg = − 16.96 200 mg/kg = − 7.32 400 mg/kg = 0.38 |
Cold restraint stress-induced ulcerated rats. | Hydromethanolic | 3 hrs | 100 mg/kg = 33.77 200 mg/kg = 49.93 400 mg/kg = 53.22 | 100 mg/kg = −8.08 200 mg/kg = − 12.37 400 mg/kg = − 27.53 | ||
acetic acid-induced ulcer in rats | Hydromethanolic | 20 days | 100 mg/kg = 33.54 200 mg/kg = 58.34 400 mg/kg = 67.07 | 100 mg/kg = − 30.79 200 mg/kg = − 6 400 mg/kg = 2.76 | ||
(Sisay Zewdu and Jemere Aragaw 2021) [45] | Rumex nepalensis | Pyloric ligation Rats | Hydromethanolic | 10 days | 100 mg/kg = 51.17 200 mg/kg = 59.78 400 mg/kg = 67.52 | 100 mg/kg = − 16.18 200 mg/kg = − 7.57 400 mg/kg = 0.17 |
Chloroform Fraction | 10 days | 100 mg/kg = 2.54 200 mg/kg = 4.4 400 mg/kg = 8.6 | 100 mg/kg = − 67.36 200 mg/kg = − 65.5 400 mg/kg = − 61.3 | |||
Ethyl acetate Fraction | 10 days | 100 mg/kg = 53.26 200 mg/kg = 61.4 400 mg/kg = 69.26 | 100 mg/kg = − 16.64 200 mg/kg = − 8.5 400 mg/kg = − 0.64 | |||
Aqueous fraction | 10 days | 100 mg/kg = 45.69 200 mg/kg = 55.6 400 mg/kg = 58.23 | 100 mg/kg = − 24.21 200 mg/kg = − 14.3 400 mg/kg = − 11.67 | |||
Acetic acid-induced ulcer Rats | Hydromethanolic | 15 days | 100 mg/kg = 26.1 200 mg/kg = 51.82 400 mg/kg = 54.59 | 100 mg/kg = − 36.94 200 mg/kg = − 9.82 400 mg/kg = − 8.45 | ||
(Yismaw, Abdelwuhab et al. 2020) [50] | Cordia africana Lam Boraginaceae) | Pyloric Ligated Rats | Methanol | 10 days | 600 mg/kg = 59.73 | 600 mg/kg = − 0.28 |
(Hailu 2021) [20] | Ensete ventricosum (Welw.) Cheesman (Musaceae) | Indomethacin induced Rat | Aqueous extract | 6 hrs | 100 mg/kg = 25.8 200 mg/kg = 42.3 400 mg/kg = 71.7 | 100 mg/kg = − 73.5 200 mg/kg = − 57 400 mg/kg = − 27.6 |
Ethanol-induced Rat | Aqueous extract | 1 hr. | 100 mg/kg = 24.24 200 mg/kg = 41.6 400 mg/kg = 55.04 | 100 mg/kg = − 46.08 200 mg/kg = − 28.72 400 mg/kg = − 15.28 | ||
Pyloric Ligated Rats | Aqueous extract | 4 hrs | 100 mg/kg = 40.07 200 mg/kg = 60.38 400 mg/kg = 98.53 | 100 mg/kg = − 59.53 200 mg/kg = − 39.22 400 mg/kg = − 1.07 | ||
(Ahmed 2019) [3] | Urtica simensis | Pyloric Ligated Rats | Aqueous extract | 6 hrs | 100 mg/kg = 33.7 200 mg/kg = 52.5 400 mg/kg = 65.5 | 100 mg/kg = − 35.8 200 mg/kg = − 17 400 mg/kg = − 4.2 |
Methanol extract | 6 hrs | 100 mg/kg = 34.8 200 mg/kg = 55.3 400 mg/kg = 67 | 100 mg/kg = − 34.7 200 mg/kg = − 14.2 400 mg/kg = − 2.5 | |||
Ethanol ulcer induced | Aqueous extract | 5 days | 200 mg/kg = 72.3 | 200 mg/kg = − 1 | ||
Methanol extract | 5 days | 200 mg/kg = 72.8 | 200 mg/kg = − 0.5 | |||
Indomethacin ulcer induced | Aqueous extract | 5 days | 200 mg/kg = 73.21 | 200 mg/kg = − 2.29 | ||
Methanol | 5 days | 200 mg/kg = 74.4 | 200 mg/kg = − 1.2 |