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International Journal of Phytomedicine and Phytotherapy

Fig. 7 | Clinical Phytoscience

Fig. 7

From: Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

Fig. 7

Effect of CCAE on liver histology. Liver histology was studied using H&E (200 ×) and Oil Red O staining. According to H&E, large macrovesicular LDs accumulated in the liver of early-stage T2D; CCAE treatment eliminated the large LDs. Lipid in the LT2D liver was not noticeable, perhaps due to its different (microvesicular) morphology. Fibrosis of the portal area and fibroblast accumulation in the liver were other remarkable manifestations in the late-stage diabetic liver tissues, which did not seem to improve by CCAE treatment. Oil Red O staining approved the greater extent of fat accumulation in diabetic livers and the capacity of CCAE to decrease hepatic fat

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