Articles

African locust bean (Parkia biglobosa, Jacq Benth) leaf extract affects mitochondrial redox chemistry and inhibits angiotensin-converting enzyme in vitro

Parkia biglobosa leaf has popular ethnomedicinal use in tropical Africa. However, little is known about its molecular biological effects. This study sought to investigate the in vitro ...

Authors: Kayode Komolafe, Afolabi C. Akinmoladun, Titilope R. Komolafe, Mary T. Olaleye, Akintunde A. Akindahunsi and Joao B. T. Rocha

Improved micropropagation of Bacopa monnieri (L.) Wettst. (Plantaginaceae) and antimicrobial activity of in vitro and ex vitro raised plants against multidrug-resistant clinical isolates of urinary tract infecting (UTI) and respiratory tract infecting (RTI) bacteria

Nowadays the multidrug-resistant (MDR) bacterial pathogens are a major concern of the medical science. Medicinal plants may be considered as new sources for producing antibacterial agents. The present study ai...

Authors: Sk Moquammel Haque, Avijit Chakraborty, Diganta Dey, Swapna Mukherjee, Sanghamitra Nayak and Biswajit Ghosh

Neuroprotective effects of Peltophorum pterocarpum leaf extract against hydrogen peroxide induced oxidative stress and cytotoxicity

Peltophorum pterocarpum is a plant from the family of Leguminosae and a tropical tree found in South East Asia region. The leaves of the plant is rich in anti-oxidant polyphenols. Trad...

Authors: Theanmalar Masilamani, Thavamanithevi Subramaniam, Norshariza Nordin and Rozita Rosli

Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

Artesunate-amodiaquine (AS-AQ) is an antimalarial drug. It is associated with improved cure rates, accelerated response to therapy and delayed development of resistance. However, liver damage, neurotoxicity an...

Authors: Mitchel Otieno Okumu, Francis Okumu Ochola, James Mucunu Mbaria, Laetitia Wakonyu Kanja, Daniel Waweru Gakuya, Alice Wairimu Kinyua, Paul Onyango Okumu and Stephen Gitahi Kiama

Toxicological implications of the therapeutic use of Acalypha wilkesiana leaves in traditional medicine

In traditional medicine, Acalypha wilkesiana is frequently used solely or as a composite part of many herbal preparations for therapeutic purposes. This study was therefore conducted to evaluate the effects of or...

Authors: Kingsley Omage, Marshall A. Azeke, Jerry N. E. Orhue and Sylvia O. Iseghohi

Pleurotus tuber-regium mushrooms in the diet of rats ameliorates reproductive and testicular injury caused by carbon tetrachloride

The incidence of male infertility arising from male sexual dysfunction is high especially in the sub saharan Africa. African foods may hold promise to reverse this trend. The aim of this study therefore is to ...

Authors: Kenneth Obinna Okolo, Orish Ebere Orisakwe and Iyeopu Minakiri Siminialayi

Comprehensive evaluation of pharmacological properties of Olea europaea L. for Cosmeceuticals prospects

Propionibacterium acnes (anaerobic bacteria) and Staphylococcus epidermidis (aerobic bacteria) have been acknowledged as key comedone forming pathological factor, eliciting an inflamma...

Authors: Afifa Qidwai, Manisha Pandey, Rajesh Kumar and Anupam Dikshit

The effect of black tea on human cognitive performance in a cognitive test battery

Black Tea is a widely consumed drink in the world. Evidence suggest Black Tea has stimulatory effect on humans. We investigated the effect of Black Tea on cognition using a cognitive test battery.

Authors: Ashfique Rizwan, Artyom Zinchenko, Ceyona Özdem, Md. Sohel Rana and Md. Mamun Al-Amin

Bioactivities of Bruguiera gymnorrhiza and profiling of its bioactive polyphenols by HPLC-DAD

In folk medicine leaves and stem of Bruguiera gymnorrhiza (L.) are commonly used to treat diarrhea, fever, diabetes, pain and a number of ailments. The present study was carried out to explore antioxidant, analge...

Authors: Imtiaz Mahmud, Md. Nazmul Hasan Zilani, Nripendra Nath Biswas and Bishwajit Bokshi

Sinupret® as add-on therapy to saline irrigation for children with acute Post-Viral Rhinosinusitis

The present randomized controlled study investigated the efficacy of the complex herbal medicine Sinupret® syrup in the treatment of acute post-viral rhinosinusitis in children.

Authors: Vasyl I. Popovich and Ivanna V. Koshel

Canephron® N in the treatment of recurrent cystitis in women of child-bearing Age: a randomised controlled study

The aim of this study was to investigate the effect of the herbal medicine Canephron®N, particularly regarding its ability to prevent recurrences of cystitis, associated with E.Coli in women of child-bearing age.

Authors: Maksim Sabadash and Alexander Shulyak

How the microbiome is influenced by the therapy of urological diseases: standard versus alternative approaches

Until recently the generally accepted paradigm implied that urine of healthy people is sterile. In the meantime several studies have established also a microbiome in the bladder with many different species. Wh...

Authors: Kurt G. Naber, Mikhail Kogan, Florian M. E. Wagenlehner, Roswitha Siener and André Gessner

The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution

The dried fruits of the chaste tree Vitex agnus castus (VAC) were traditionally used by monks as a substitute for pepper and was therefore also called Monk’s pepper. For the last 50 years it is commercially provi...

Authors: Dana Seidlova-Wuttke and Wolfgang Wuttke

Biological activity of Bauhinia racemosa against Diabetes and Interlinked Disorders like Obesity and Hyperlipidemia

Bauhinia racemosa Lam. (BR) has been used widely for the treatment of diabetes since ancient times. Along with its medicinal importance; the tree having great traditional value in Indi...

Authors: Vivek Kumar, Kalpana Rathore, Parag Jain and Zabeer Ahmed

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

Cancer causes leading death in the world population due to exposure of various carcinogenic/mutagenic agents, radiation and life style. There are 2.6 million new cases diagnosed each year. Therefore, the objec...

Authors: Arumugama Ponnan, Kavipriya Ramu, Murugan Marudhamuthu, Ramar Marimuthu, Kamalakannan Siva and Murugan Kadarkarai

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Dennettia tripetala is a medicinal plant with in vitro antioxidant activities. It is capable of protecting the liver and kidney of rats from damage when administered prior to a single ...

Authors: Sylvia O. Iseghohi and Noghayin E. J. Orhue

Gastrothylax crumenifer: Ultrastructure and histopathology study of in vitro trematodicidal action of Marattia fraxinea (Sm.)

Trematodicidal action of Marattia fraxinea (Sm.) rhizome, extracts against adult Gastrothylax crumenifer and its morphological changes under light and scanning electron microscope was studied in this work. This p...

Authors: Kalpana Devi Rajesh, Vasantha Subramani, Panneerselvam Annamalai, Rajesh Nakulan V., Jeyathilakan Narayanaperumal, Perumal Ponraj and Rajasekar Durai

Carbon tetrachloride induced hepatorenal toxicity in rats: possible protective effects of wild Pleurotus tuber-regium

The economic cost of and liver and kidney diseases in Sub Saharan Africa remain prohibitive, hence the quest for medicinal foods that can reverse hepato-renal damages. The aim of this study is to investigate t...

Authors: Kenneth Obinna Okolo, Iyeopu Minakiri Siminialayi and Orish Ebere Orisakwe

Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

Oxidative stress is found as one of the causes in various pathological conditions. It has been proven in many studies that medicinal plants have antioxidant constituents that help in coping with the oxidative ...

Authors: Harsha Lad and Deepak Bhatnagar

African natural products with potential antioxidants and hepatoprotectives properties: a review

Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals esp...

Authors: Bashir Lawal, Oluwatosin K. Shittu, Florence I. Oibiokpa, Eustace B. Berinyuy and Hadiza Mohammed

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

In the current study in vitro antioxidant, thrombolytic and in vivo analgesic, anti-inflammatory, anti-diarrheal activities of methanol extract of Ixora cuneifolia leaves (MEIL) were investigated.

Authors: Tamanna Binte Huq, M. Sohanur Rahman, M. Akhlatun Nure, Md Solayman Hossain, Abeer Sarwar, Azharul Islam, Munny Das, Md Emdadul Haque, Tasnia Malik, Md Wali Reza, Bikash Chandra Adhikary, Minhazur Rahman, Taslima Begum and Mst Marium Begum

Erratum to: Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice

Authors: Jarinyaporn Naowaboot and Pritsana Piyabhan

Vitex agnus-castus dry extract BNO 1095 (Agnucaston^®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

For many women, the monthly suffering induced by menstrual “cramps” is severe enough to profoundly disrupt their quality of life. In the case of primary dysmenorrhea, a condition related to premenstrual syndro...

Authors: Johann Röhrl, Oliver Werz, Aldo Ammendola and Gerald Künstle

Effects of Garcinia kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats

Garcinia kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fung...

Authors: Ene B. Adejor, Danladi A. Ameh, Dorcas B. James, Olumuyiwa A. Owolabi and Uche S. Ndidi

Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice

Senna alata (S. alata) has numerous pharmacological activities including anti-lipogenic effect in high-fat diet (HFD)-induced obese mice. The present study investigated the effect of S...

Authors: Jarinyaporn Naowaboot and Pritsana Piyabhan

Antioxidative and neuroprotective effects of Leea macrophylla methanol root extracts on diazepam-induced memory impairment in amnesic Wistar albino rat

A neurological disorder is becoming one of the major health problems worldwide. Synthetic drugs for neurological disorders often produce unwanted effects while traditional plant- derived drugs offer a unique s...

Authors: Sakia Ferdousy, Md Atiar Rahman, Md Mamun Al-Amin, Jannatul Aklima and J. M. Kamirul Hasan Chowdhury

An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Drugs are an important cause of liver injury. The use of natural remedies for the treatment of liver diseases has a long history and medicinal plants are still used all over the world for this purpose. For the...

Authors: Maryam Moossavi, Reyhane Hoshyar, Mina Hemmati, Ali Farahi and Hossein Javdani

A preliminary evaluation of effects of high doses of Jujube and Saffron on biochemical and hematological parameters in rats

We investigated effects of high doses of Jujube fruits and Saffron petals on biochemical and hematological biomarkers in rats. During 14 days treatment of herbs, mortality was not observed. No difference repor...

Authors: Banafsheh Safizadeh, Reyhane Hoshyar, Mina Hemmati, Asghar Zarban and Roshanak Ebrahimi

Alcoholic lung injury: pineapple peel extract modulates antioxidant enzymes and attenuates lipid peroxidation in rat models

The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. GC – MS was used in characterizing secondary metabolites of th...

Authors: Ochuko L. Erukainure, John A. Ajiboye, Oluwatoyin Y. Okafor, Emeka E. Okoro, Godfrey Asieba, Bolanle B. Sarumi, Sunday O. Adenekan and Moses Z. Zaruwa

Phytochemical screening, antioxidant and antimicrobial activities of Acalypha ciliata plant

Phytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work. This plant according to folk medicine has ...

Authors: Oluwakayode Odeja, Christiana Ene Ogwuche, Elias Emeka Elemike and Grace Obi

Retraction Note: Phytochemical Screening, Antioxidant and Antimicrobial activities of Senna occidentalis (L.) leaves Extract

Authors: Oluwakayode Odeja, Grace Obi, Christiana Ene Ogwuche, Elias Emeka Elemike and Yemi Oderinlo

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Oxidative stress (OS) has been linked to the pathology of a variety of chronic and degenerative diseases. Medicinal plants contain bioactive compounds which are capable of preventing and fighting these disease...

Authors: Anthonet Ndidi Ezejiofor, Nnaemeka Arinze Udowelle and Orish Ebere Orisakwe

Assessment of antistaphylococcal activity of ethanolic extract of Lenzites quercina (L) P. Karsten against clinical Staphylococcus species

Bioactive compounds in wild medicinal mushrooms are known to contain potent antimicrobial property. Hence, there is need to assess the antimicrobial properties of these wild mushrooms in order to adequately ut...

Authors: Zeniyat Abubakar, Olusola Clement Ogidi and Victor Olusegun Oyetayo

Ethnopharmacological investigations of methanolic extract of Pouzolzia Zeylanica (L.) Benn

Phytochemical derived from plant consisting of phenols and flavonoids possess antioxidant properties, which are useful to scavenge reactive oxygen species (ROS). The aim of the work is to ascertain the level o...

Authors: Md Solayman Hossain, M. Sohanur Rahman, A. H. M. Rahmatullah Imon, Sinthia Zaman, A. S. M. Badrul Alam Siddiky, Milon Mondal, Abeer Sarwar, Tamanna Binte Huq, Bikash Chandra Adhikary, Taslima Begum, Asma Tabassum, Sumaiya Alam and Mst Marium Begum

Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays

Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) related to Alzheimer’s disease as well as tyrosinase (TYR) relevant to Parkinson’s disease is an important approach to find novel drug...

Authors: Ilkay Erdogan Orhan, Fatma Sezer Senol, Mehmet Zeki Haznedaroglu, Halil Koyu, Sinem Aslan Erdem, Gulderen Yılmaz, Mehmet Cicek, A. Emre Yaprak, Esin Ari, Nurgun Kucukboyaci and Gulnur Toker

Efficiency of Canephron N in complex treatment of experimental heymann glomerulonephritis

While the most common pharmacological treatments for autoimmune renal pathologies are well studied, herbal remedies are often overlooked. In this study, the effect of the herbal treatment Canephron® N (CAN) in...

Authors: Konstantin V. Sivak, Elena E. Lesiovskaya, Kira I. Stosman and Tatyana N. Savateeva-Lubimova

Effectiveness and tolerability of Tonsilgon® N in the treatment of recurrent upper respiratory tract infections in children: a non-interventional study in Russia

Acute upper respiratory tract infections (ARI) in children are quite common and often recurrent. Overuse of antibiotics must be avoided, and thus herbal remedies are a useful therapeutic option, as most ARIs c...

Authors: Vera P. Vavilova, Dimitri Abramov-Sommariva, Hubert Steindl, Meinolf Wonnemann, Elena G. Ryzhova, Tatiana V. Rusova, Alexander A. Lebedenko and Ivan I. Kolchenko

The potential of silymarin for the treatment of hepatic disorders

Silymarin has long been used as a hepatoprotective remedy. Chronic toxicity studies in rodents have confirmed that silymarin has a very low toxicity. These data support its history as a safe medication in hepa...

Authors: Claus Hellerbrand, Jörn M. Schattenberg, Philipp Peterburs, Anja Lechner and Reto Brignoli

A new derivative of ionone from aerial parts of Viola odorata Linn. and its antibacterial role against respiratory pathogens

Viola odorata, widely distributed in Eastern and Western Himalaya region is extensively used in treatment of various respiratory ailment, calculous affections and nervous disorders. It...

Authors: Shiv Shanker Gautam, Navneet Bithel, Sanjay Kumar, Deepak Painuly and Jashbir Singh

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

Finding a treatment for diabetes that does not have side effects has remained elusive. Among natural agents, much attention has been focused on phenolic compounds. For both their medicinal and nutritional valu...

Authors: Mina Hemmati, Elham Serki, Maryam Gholami and Reyhane Hoshyar

A preliminary evaluation of cytotoxicity, antihyperglycemic and antinociceptive activity of Polygonum hydropiper L. ethanolic leaf extract

Polygonum hydropiper L. is used by folk medicinal practitioners of Bangladesh. Juice of leaves is used in headache, pain, toothache, liver enlargement, gastric ulcer, dysentery, loss o...

Authors: Arafat Rahman Oany, Al Ahad Siddikey, Mohammad Uzzal Hossain, Rafiad Islam and Abdullah-Al Emran

Effects of black cohosh on estrogen biosynthesis in hippocampus of non-human primates ex vivo in vitro and in human neuroblastoma cells in vitro

Estrogens have neuroprotective properties. The aim of the study was to assess the impact of an isopropanolic extract of Cimicifuga racemosa (iCR), 17ß-estradiol (E2), testosterone (T) and Tibolone’s 3α-OH meta...

Authors: Petra Stute, Gunnar Habermann, Ludwig Kiesel, Hans-Heinrich Henneicke-von Zepelin and Susana Garcia de Arriba

Nobelprize 2015 for Phytomedicine

Authors: André Gessner

Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

Hormone replacement therapy is still a popular and most effective treatment for vasomotor symptoms and bone loss prevention in the postmenopause but it is not without risks. This has driven many climacteric wo...

Authors: Wolfgang Wuttke and Dana Seidlová-Wuttke

Cruciferous vegetables: prototypic anti-inflammatory food components

There is increasing evidence that food components contribute to the pathogenesis of various disorders such as inflammatory bowel diseases, atherosclerosis, cancer or type 2 diabetes. Dietary factors especially...

Authors: Herbert Tilg

Acute toxicity studies of Myrsine africana aqueous seed extract in male Wistar rats on some hematological and biochemical parameters

Natural medicinal products have gained recognition worldwide in the treatment and control of diseases. One of the major concerns as they are used is the lack of adequate pharmacological and toxicological data ...

Authors: Zelipha N. Kabubii, James Mbaria and Mbaabu Mathiu

Safety of Canephron® N for the treatment of urinary tract infections in the first trimester of pregnancy

Urinary tract infections (UTIs) are among the most commonly occurring bacterial infections, particularly in pregnant women. Canephron® N (Bionorica, Germany) is a phytotherapeutic medicinal product that has pl...

Authors: Volodymir Medved

Sinupret® oral drops protect against respiratory epithelium atrophy in experimental acute rhinitis

More than 90 % of uncomplicated upper respiratory tract infections are caused by viruses, with a risk of developing subsequent bacterial infections in some patients. The risk of development of microbial compli...

Authors: Svitlana Yaremchuk, Dmytro Zabolotny, Іgor Vareniuk, Nikolay Makarchuk and Stanislav Veselsky

An open label, non-controlled, multicentre, interventional trial to investigate the safety and efficacy of Canephron® N in the management of uncomplicated urinary tract infections (uUTIs)

Despite of increasing prevalence of bacterial resistance to antibiotics and possible adverse drug reactions (ADRs), uncomplicated lower urinary tract infections (uUTIs) are usually treated with antibiotics. Ca...

Authors: Dmitry Ivanov, Dimitri Abramov-Sommariva, Kathrin Moritz, Herbert Eskötter, Tatyana Kostinenko, Liliya Martynyuk, Nikolay Kolesnik and Kurt G Naber

RETRACTED ARTICLE: Phytochemical Screening, Antioxidant and Antimicrobial activities of Senna occidentalis (L.) leaves Extract

Phytochemical screening, antimicrobial and antioxidant activities of the hexane, ethylacetate and methanol crude extracts of Senna occidentalis (L.) leaves were studied in this work. The ...

Authors: Oluwakayode Odeja, Grace Obi, Christiana Ene Ogwuche, Elias Emeka Elemike and Yemi Oderinlo