Articles

Anthelmintic activity of Piper sylvaticum Roxb. (family: Piperaceae): In vitro and in silico studies

The present study was conducted to investigate the anthelmintic activity of methanol extract of Piper sylvaticum stem (MEPSS) in experimental model followed by in silico molecular docking study and ADME/T analysi...

Authors: Arkajyoti Paul, Md. Adnan, Mohuya Majumder, Niloy Kar, Muntasir Meem, Mohammed Shahariar Rahman, Akash Kumar Rauniyar, Nishat Rahman, Md. Nazim Uddin Chy and Mohammad Shah Hafez Kabir

Correction to: Phytochemical studies, antiangiogenic, antiinflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon

Following the publication of this article [1], the authors noticed that Figs. 1, 2 and 3 were in the incorrect order and thus had incorrect captions. The images that were incorrectly published as Figs. 1, 2 an...

Authors: Rick-Leonid Ngoua-Meye-Misso, Jean De La Croix Ndong, Cédric Sima-Obiang, Joseph Privat Ondo, Guy Roger Ndong-Atome, Felix Ovono Abessolo and Louis-Clément Obame-Engonga

Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and...

Authors: Mahadi Hasan, Mohammad Tuhin Ali, Rifat Khan, Parag Palit, Aminul Islam, Veronique Seidel, Rabeya Akter and Laizuman Nahar

Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon

The search for new anti-cancer molecules is one of the main concerns of oncology researchers. Scyphocephalium ochocoa is a plant of Myristicaceae family, used in traditional medicine against inflammatory diseases...

Authors: Rick-Leonid Ngoua-Meye-Misso, Jean De La Croix Ndong, Cédric Sima-Obiang, Joseph Privat Ondo, Guy Roger Ndong-Atome, Felix Ovono Abessolo and Louis-Clément Obame-Engonga

Pharmacological activities of leaf and bark extracts of a medicinal mangrove plant Avicennia officinalis L.

Avicennia officinalis is a medicinally important mangrove plant and used in traditional medicinal practices to treat various ailments like rheumatism, paralysis, asthma, dyspepsia, tumors etc. The objective of th...

Authors: Swagat Kumar Das, Dibyajyoti Samantaray, Archana Mahapatra, Nityasundar Pal, Rudranarayan Munda and Hrudayanath Thatoi

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

Zingiber officinale is a rhizome commonly consumed as a delicacy, medicine or spice. It is considered as a safe spice with several medicinal properties. The aim of this study was to evaluate in-vitro antioxidants...

Authors: Abubakar A. Yusuf, Bashir Lawal, Asmau N. Abubakar, Eustace B. Berinyuy, Yemisi O. Omonije, Sheriff I. Umar, Mohammed N. Shebe and Yusuf M. Alhaji

Anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Abutilon hirtum (Lam.) Sweet

Many plants of genus Abutilon are traditionally used for treatment of inflammation, bronchitis, piles, gonorrhea, diabetes and fever. Abutilon hirtum is traditionally used to ease the pain of kidney gravel, to tr...

Authors: Alshymaa A.-R. Gomaa, Mamdouh N. Samy, Samar Y. Desoukey and Mohamed S. Kamel

Caffeic acid rich Citrus macroptera peel powder supplementation prevented oxidative stress, fibrosis and hepatic damage in CCl₄ treated rats

Citrus macroptera has been used as a culinary fruit and medicinal plant in traditional medicine system in Bangladesh. The aim of the present study was to evaluate the presence of phenolic compounds in Citrus macr...

Authors: Md Ashraful Alam, Abu Taher Sagor, Nabila Tabassum, Anayt Ulla, Manik Chandra Shill, Ghazi Muhammad Sayedur Rahman, Hemayet Hossain and Hasan Mahmud Reza

Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase

In the past few years, there has been a tremendous increase in the number of plant-based health supplements with respect to their safety and efficacy in diseases treatment and prevention. Solanum dasyphyllum, als...

Authors: Efe Obade, Omotayo B. Ilesanmi, Olamide Crown, Afolabi C. Akinmoladun, Tolulope M. Olaleye and Akintunde A. Akindahunsi

A dose Dependent hepatoprotective and nephroprotective activity of eucalyptus oil on Streptozotocin induced diabetic mice model

Eucalyptus globulus are a prime source of global eucalyptus oil production. This oil has therapeutic, flavoring, antimicrobial, and biopesticide properties. This oil has got popularity because they are reported a...

Authors: Monalisa Chakraborty, Biswajoy Bagchi, Sukhen Das, Ruma Basu and Papiya Nandy

Evaluation of wound healing effect of herbal lotion in albino rats and its antibacterial activities

This particular study emphasis on the in vivo wound healing and in vitro antibacterial activity of herbal lotions preparated from Ethanolic extract of Justicia tranquebariensis, Aloe vera and Curcuma longa.

Authors: T. Dons and S. Soosairaj

Evaluation of phytochemical composition and antioxidative, hypoglycaemic and hypolipidaemic properties of methanolic extract of Hemidesmus indicus roots in streptozotocin-induced diabetic mice

Hemidesmus indicus is an important medicinal plant and extensively used in Ayurvedic and Unani system of medicine. The aim of the study was to evaluate the antioxidant, hypoglycaemic and hypolipidemic potential o...

Authors: Ankita Joshi, Harsha Lad, Harsha Sharma and Deepak Bhatnagar

Evaluation of antioxidant and antibacterial activities of Crotalaria pallida stem extract

Antioxidants play an important role in protecting cellular damage by reactive oxygen species. The aim of the present study is to assess the phytochemical nature, antioxidant and antibacterial activities of pet...

Authors: Md. Zahidul Islam, Md. Tanvir Hossain, Foysal Hossen, Sanjoy Kumar Mukharjee, Nahid Sultana and Shujit Chandra Paul

A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts

The herbal medicinal product Bronchipret® TP film-coated tablets contains a fixed combination of thyme and primula dry extracts (BRO) and has long and successfully been used for the treatment of acute bronchit...

Authors: Jan Seibel, Meinolf Wonnemann, Oliver Werz and Martin D. Lehner

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

Typha elephantina Roxb. is a widely scattered grass like medicinal plant in Bangladesh and thus demands biological investigations to discover its therapeutic potentiality. The aim of our present study was to asse...

Authors: Niloy Sen, Latifa Bulbul, Md. Saddam Hussain, Sujan Banik and Md. Shahbuddin Kabir Choudhuri

Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets

This study was conducted to evaluate the therapeutic benefits of oral administration of extracts of Acalypha wilkesiana leaves on some serum parameters that are indicators or risk factors of cardiovascular diseas...

Authors: Kingsley Omage, Marshall A. Azeke and Sylvia O. Omage

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Commelina diffusa Burm. (Family: Commelinaceae) is usually known as “climbing dayflower or spreading dayflower” in Bangladesh. The plant is used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrh...

Authors: Tania Sultana, Md. Abdul Mannan and Tajnin Ahmed

Screening of phytochemical and pharmacological activities of Syzygium caryophyllatum (L.) Alston

The systematic screening of plant species with the purpose of discovering new bioactive compounds is prerequisite for any bioprospecting study. Therefore the present study was carried out to assess the phytoch...

Authors: Stalin N and Sudhakar Swamy P

A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows vasocontrictive effects in an ex-vivo mucosal tissue model and in allergic rhinitis patients

This study aimed to investigate the nasal decongestive efficacy of an alternative to pharmacotherapy, a herbal nasal spray composed of Scutellaria baicalensis and Eleutherococcus senticosus.

Authors: Michael Katotomichelakis, K. Van Crombruggen, G. Holtappels, F. A. Kuhn, C. E. Fichandler, C. A. Kuhn-Glendye, J. B. Anon, C. T. Melroy, B. Karanfilov, T. W. Haegen, I. Kastanioudakis, C. Bachert and N. Zhang

Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Persicaria hydropiper Linn. (Family: Polygonaceae), it grows in damp places and the bank of rivers, canals, lakes, and roadsides of Bangladesh. The leaves of the plant used in traditio...

Authors: Md. Shahed-Al-Mahmud and Shah Marzia Mahjabin Lina

African locust bean (Parkia biglobosa, Jacq Benth) leaf extract affects mitochondrial redox chemistry and inhibits angiotensin-converting enzyme in vitro

Parkia biglobosa leaf has popular ethnomedicinal use in tropical Africa. However, little is known about its molecular biological effects. This study sought to investigate the in vitro ...

Authors: Kayode Komolafe, Afolabi C. Akinmoladun, Titilope R. Komolafe, Mary T. Olaleye, Akintunde A. Akindahunsi and Joao B. T. Rocha

Improved micropropagation of Bacopa monnieri (L.) Wettst. (Plantaginaceae) and antimicrobial activity of in vitro and ex vitro raised plants against multidrug-resistant clinical isolates of urinary tract infecting (UTI) and respiratory tract infecting (RTI) bacteria

Nowadays the multidrug-resistant (MDR) bacterial pathogens are a major concern of the medical science. Medicinal plants may be considered as new sources for producing antibacterial agents. The present study ai...

Authors: Sk Moquammel Haque, Avijit Chakraborty, Diganta Dey, Swapna Mukherjee, Sanghamitra Nayak and Biswajit Ghosh

Neuroprotective effects of Peltophorum pterocarpum leaf extract against hydrogen peroxide induced oxidative stress and cytotoxicity

Peltophorum pterocarpum is a plant from the family of Leguminosae and a tropical tree found in South East Asia region. The leaves of the plant is rich in anti-oxidant polyphenols. Trad...

Authors: Theanmalar Masilamani, Thavamanithevi Subramaniam, Norshariza Nordin and Rozita Rosli

Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

Artesunate-amodiaquine (AS-AQ) is an antimalarial drug. It is associated with improved cure rates, accelerated response to therapy and delayed development of resistance. However, liver damage, neurotoxicity an...

Authors: Mitchel Otieno Okumu, Francis Okumu Ochola, James Mucunu Mbaria, Laetitia Wakonyu Kanja, Daniel Waweru Gakuya, Alice Wairimu Kinyua, Paul Onyango Okumu and Stephen Gitahi Kiama

Toxicological implications of the therapeutic use of Acalypha wilkesiana leaves in traditional medicine

In traditional medicine, Acalypha wilkesiana is frequently used solely or as a composite part of many herbal preparations for therapeutic purposes. This study was therefore conducted to evaluate the effects of or...

Authors: Kingsley Omage, Marshall A. Azeke, Jerry N. E. Orhue and Sylvia O. Iseghohi

Pleurotus tuber-regium mushrooms in the diet of rats ameliorates reproductive and testicular injury caused by carbon tetrachloride

The incidence of male infertility arising from male sexual dysfunction is high especially in the sub saharan Africa. African foods may hold promise to reverse this trend. The aim of this study therefore is to ...

Authors: Kenneth Obinna Okolo, Orish Ebere Orisakwe and Iyeopu Minakiri Siminialayi

Comprehensive evaluation of pharmacological properties of Olea europaea L. for Cosmeceuticals prospects

Propionibacterium acnes (anaerobic bacteria) and Staphylococcus epidermidis (aerobic bacteria) have been acknowledged as key comedone forming pathological factor, eliciting an inflamma...

Authors: Afifa Qidwai, Manisha Pandey, Rajesh Kumar and Anupam Dikshit

The effect of black tea on human cognitive performance in a cognitive test battery

Black Tea is a widely consumed drink in the world. Evidence suggest Black Tea has stimulatory effect on humans. We investigated the effect of Black Tea on cognition using a cognitive test battery.

Authors: Ashfique Rizwan, Artyom Zinchenko, Ceyona Özdem, Md. Sohel Rana and Md. Mamun Al-Amin

Bioactivities of Bruguiera gymnorrhiza and profiling of its bioactive polyphenols by HPLC-DAD

In folk medicine leaves and stem of Bruguiera gymnorrhiza (L.) are commonly used to treat diarrhea, fever, diabetes, pain and a number of ailments. The present study was carried out to explore antioxidant, analge...

Authors: Imtiaz Mahmud, Md. Nazmul Hasan Zilani, Nripendra Nath Biswas and Bishwajit Bokshi

Sinupret® as add-on therapy to saline irrigation for children with acute Post-Viral Rhinosinusitis

The present randomized controlled study investigated the efficacy of the complex herbal medicine Sinupret® syrup in the treatment of acute post-viral rhinosinusitis in children.

Authors: Vasyl I. Popovich and Ivanna V. Koshel

Canephron® N in the treatment of recurrent cystitis in women of child-bearing Age: a randomised controlled study

The aim of this study was to investigate the effect of the herbal medicine Canephron®N, particularly regarding its ability to prevent recurrences of cystitis, associated with E.Coli in women of child-bearing age.

Authors: Maksim Sabadash and Alexander Shulyak

How the microbiome is influenced by the therapy of urological diseases: standard versus alternative approaches

Until recently the generally accepted paradigm implied that urine of healthy people is sterile. In the meantime several studies have established also a microbiome in the bladder with many different species. Wh...

Authors: Kurt G. Naber, Mikhail Kogan, Florian M. E. Wagenlehner, Roswitha Siener and André Gessner

The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution

The dried fruits of the chaste tree Vitex agnus castus (VAC) were traditionally used by monks as a substitute for pepper and was therefore also called Monk’s pepper. For the last 50 years it is commercially provi...

Authors: Dana Seidlova-Wuttke and Wolfgang Wuttke

Biological activity of Bauhinia racemosa against Diabetes and Interlinked Disorders like Obesity and Hyperlipidemia

Bauhinia racemosa Lam. (BR) has been used widely for the treatment of diabetes since ancient times. Along with its medicinal importance; the tree having great traditional value in Indi...

Authors: Vivek Kumar, Kalpana Rathore, Parag Jain and Zabeer Ahmed

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

Cancer causes leading death in the world population due to exposure of various carcinogenic/mutagenic agents, radiation and life style. There are 2.6 million new cases diagnosed each year. Therefore, the objec...

Authors: Arumugama Ponnan, Kavipriya Ramu, Murugan Marudhamuthu, Ramar Marimuthu, Kamalakannan Siva and Murugan Kadarkarai

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Dennettia tripetala is a medicinal plant with in vitro antioxidant activities. It is capable of protecting the liver and kidney of rats from damage when administered prior to a single ...

Authors: Sylvia O. Iseghohi and Noghayin E. J. Orhue

Gastrothylax crumenifer: Ultrastructure and histopathology study of in vitro trematodicidal action of Marattia fraxinea (Sm.)

Trematodicidal action of Marattia fraxinea (Sm.) rhizome, extracts against adult Gastrothylax crumenifer and its morphological changes under light and scanning electron microscope was studied in this work. This p...

Authors: Kalpana Devi Rajesh, Vasantha Subramani, Panneerselvam Annamalai, Rajesh Nakulan V., Jeyathilakan Narayanaperumal, Perumal Ponraj and Rajasekar Durai

Carbon tetrachloride induced hepatorenal toxicity in rats: possible protective effects of wild Pleurotus tuber-regium

The economic cost of and liver and kidney diseases in Sub Saharan Africa remain prohibitive, hence the quest for medicinal foods that can reverse hepato-renal damages. The aim of this study is to investigate t...

Authors: Kenneth Obinna Okolo, Iyeopu Minakiri Siminialayi and Orish Ebere Orisakwe

Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

Oxidative stress is found as one of the causes in various pathological conditions. It has been proven in many studies that medicinal plants have antioxidant constituents that help in coping with the oxidative ...

Authors: Harsha Lad and Deepak Bhatnagar

African natural products with potential antioxidants and hepatoprotectives properties: a review

Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals esp...

Authors: Bashir Lawal, Oluwatosin K. Shittu, Florence I. Oibiokpa, Eustace B. Berinyuy and Hadiza Mohammed

Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves

In the current study in vitro antioxidant, thrombolytic and in vivo analgesic, anti-inflammatory, anti-diarrheal activities of methanol extract of Ixora cuneifolia leaves (MEIL) were investigated.

Authors: Tamanna Binte Huq, M. Sohanur Rahman, M. Akhlatun Nure, Md Solayman Hossain, Abeer Sarwar, Azharul Islam, Munny Das, Md Emdadul Haque, Tasnia Malik, Md Wali Reza, Bikash Chandra Adhikary, Minhazur Rahman, Taslima Begum and Mst Marium Begum

Erratum to: Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice

Authors: Jarinyaporn Naowaboot and Pritsana Piyabhan

Vitex agnus-castus dry extract BNO 1095 (Agnucaston^®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

For many women, the monthly suffering induced by menstrual “cramps” is severe enough to profoundly disrupt their quality of life. In the case of primary dysmenorrhea, a condition related to premenstrual syndro...

Authors: Johann Röhrl, Oliver Werz, Aldo Ammendola and Gerald Künstle

Effects of Garcinia kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats

Garcinia kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fung...

Authors: Ene B. Adejor, Danladi A. Ameh, Dorcas B. James, Olumuyiwa A. Owolabi and Uche S. Ndidi

Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice

Senna alata (S. alata) has numerous pharmacological activities including anti-lipogenic effect in high-fat diet (HFD)-induced obese mice. The present study investigated the effect of S...

Authors: Jarinyaporn Naowaboot and Pritsana Piyabhan

Antioxidative and neuroprotective effects of Leea macrophylla methanol root extracts on diazepam-induced memory impairment in amnesic Wistar albino rat

A neurological disorder is becoming one of the major health problems worldwide. Synthetic drugs for neurological disorders often produce unwanted effects while traditional plant- derived drugs offer a unique s...

Authors: Sakia Ferdousy, Md Atiar Rahman, Md Mamun Al-Amin, Jannatul Aklima and J. M. Kamirul Hasan Chowdhury

An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Drugs are an important cause of liver injury. The use of natural remedies for the treatment of liver diseases has a long history and medicinal plants are still used all over the world for this purpose. For the...

Authors: Maryam Moossavi, Reyhane Hoshyar, Mina Hemmati, Ali Farahi and Hossein Javdani

A preliminary evaluation of effects of high doses of Jujube and Saffron on biochemical and hematological parameters in rats

We investigated effects of high doses of Jujube fruits and Saffron petals on biochemical and hematological biomarkers in rats. During 14 days treatment of herbs, mortality was not observed. No difference repor...

Authors: Banafsheh Safizadeh, Reyhane Hoshyar, Mina Hemmati, Asghar Zarban and Roshanak Ebrahimi

Alcoholic lung injury: pineapple peel extract modulates antioxidant enzymes and attenuates lipid peroxidation in rat models

The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. GC – MS was used in characterizing secondary metabolites of th...

Authors: Ochuko L. Erukainure, John A. Ajiboye, Oluwatoyin Y. Okafor, Emeka E. Okoro, Godfrey Asieba, Bolanle B. Sarumi, Sunday O. Adenekan and Moses Z. Zaruwa

Phytochemical screening, antioxidant and antimicrobial activities of Acalypha ciliata plant

Phytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work. This plant according to folk medicine has ...

Authors: Oluwakayode Odeja, Christiana Ene Ogwuche, Elias Emeka Elemike and Grace Obi