Articles

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding ...

Authors: Olumide Samuel Fadahunsi, Peter Ifeoluwa Adegbola, Olubukola Sinbad Olorunnisola, Temitayo Idris Subair, David Oluwasegun Adepoju and Ayodeji Zabdiel Abijo

Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review

Black pepper [Piper nigrum (L.), Family: Piperaceae] is used traditionally for the treatment of various diseases including; cough, cold, dyspnea throat diseases, intermittent fever, dysentery, stomachache, worms ...

Authors: Kaliyaperumal Ashokkumar, Muthusamy Murugan, M. K. Dhanya, Arjun Pandian and Thomas D. Warkentin

Anti-proliferative, antioxidant effects of methanol extract of Calotropis procera leaf on lung cancer cells (H1299) and its ameliorative effect on expression of CD146 on blood cells

Calotropis procera leaf is one of the plants commonly utilized in phytomedicine in Nigeria. The present investigation explored the use of the extracts on cell viability and apoptosis respectively. In this study, ...

Authors: Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao, Zhiwei Xu, Quncheng Zhang and Xiaoju Zhang

Diosgenin and galactomannans, natural products in the pharmaceutical sciences

Diosgenin is an isospirostane derivative, which is a steroidal sapogenin and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Galactomannans are heteropolysaccharides composed of...

Authors: Mohamad Hesam Shahrajabian, Wenli Sun, Diorge Jonatas Marmitt and Qi Cheng

Antioxidant property, anti-inflammatory and analgesic effects of aqueous extracts of two onion bulbs varieties (Allium cepa L.)

oxidative stress and inflammation remain the main health problems often linked to degenerative diseases. The aim of this study was to evaluate antioxidant, analgesic and anti-inflammatory properties of onion g...

Authors: Mang Yannick Dimitry, Panyo’o Akdowa Emmanuel, Djiogue Manejo Josiane Edith, Abdou Bouba Armand and Njintang Yanou Nicolas

Protective role of Pandanus tectorius Parkinson ex Du Roi in diabetes, hyperlipidemia, liver and kidney dysfunction in alloxan diabetic rats

Diabetes mellitus (DM), an endocrine disease is characterized by increased level of blood glucose. Diabetes may affect other functions of the body and organs including, renal function and lipid metabolism. Pandan...

Authors: Saima Sundus, Khan Hira, Nida Sohail, Habiba, Amna Tariq, Jehan Ara, Viqar Sultana and Syed Ehteshamul-Haque

Nutritional, antioxidant, angiotensin-converting-enzyme and carbohydrate-hydrolyzing-enzyme inhibitory activities of underutilized leafy vegetable: African wild lettuce (Lactuca taraxacifolia Willd)

African wild lettuce (Lactuca taraxacifolia Willd.) is an underutilised indigenous leafy vegetable containing essential nutrients and medicinal properties. Hence, this study aimed to determine the chemical compos...

Authors: Oluwole Steve Ijarotimi, Ibiyinka Helen Adesanya and Timilehin David Oluwajuyitan

Correction to: Attenuation of glycation and biochemical aberrations in fructose-loaded rats by polyphenol-rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

Authors: Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C. Nkwocha and Ben Chibuzo Amadi

Antimicrobial, antioxidant, anti-inflammatory and cytotoxic study of extracts of Guibourtia tessmanii (harms) J. Léonard from Gabon

Gabonese flora abounds in a significant reserve of plants in medical matter. Thus, medicinal plants occupy a significant place in African pharmacopeia. Aim of this work was to evaluate the antimicrobial, antio...

Authors: Cédric Sima Obiang, Rick Léonid Ngoua Meye Misso, Guy Roger Ndong Atome, Rany Berty Mbeng Obame, Joseph Privat Ondo, Louis Clément Obame Engonga and Edouard Nsi Emvo

Safety assessment of the standardized aqueous extract from solid-state cultured Xylaria nigripes (Wuling Shen) in rats

Xylaria nigripes (Koltz.) Cooke, also known as Wuling Shen, is a high-value medicinal mushroom. It is a herbal medicine traditionally used for treating insomnia, trauma and depression. However, its toxicity has n...

Authors: Ming-Nan Lai, Hui-Chen Hsu and Lean-Teik Ng

Effect of Aegle marmelos on the growth of brushite crystals

The urinary stone formation is a very common health problem due to the prolonged medication. Calcium Hydrogen Phosphate Dihydrate (CaHPO₄.2H₂O, CHPD and Brushite) is one of the major constituent of urinary stone ...

Authors: G. Anushya, R. Mahesh, T. H. Freeda, R. Ramachandran and G. Raju

In vitro antimalarial activity evaluation of two ethnomedicinal plants against chloroquine sensitive and resistant strains of Plasmodium falciparum

In this study, we selected two medicinal plants Citrus maxima (Burm.) Merr. and Artemisia nilagirica (C.B. Clarke) Pamp. on the basis of their traditional use in the treatment of fever associated with malaria in ...

Authors: Neelutpal Gogoi, Bhaskarjyoti Gogoi and Dipak Chetia

Attenuation of glycation and biochemical aberrations in fructose‐loaded rats by polyphenol‐rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

Different parts of the Parkia biglobosa plant are employed in traditional medicine in different African communities. However, information ratifying its use and biochemical influence on health is still scanty in l...

Authors: Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C Nkwocha and Ben Chibuzo Amadi

Hepatoprotective activity against acetaminophen-induced liver dysfunction and GC-MS profiling of a brown algae Sargassum ilicifolium

Drug-induced hepatotoxicity is one of the most important causes of liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug is generally considered safe but its overdose may cause liver tox...

Authors: Khan Hira, Hafiza Farhat, Nida Sohail, Madeeha Ansari, Jehan Ara and Syed Ehteshamul-Haque

Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice

The problem of drug resistance and toxicity in trypanosomiasis is ever-increasing, thereby creating a need to search for efficacious and safer alternatives that are of plant origin. We designed the present stu...

Authors: Nafisa Garba Ayawa, Suleiman Babatunde Ramon-Yusuf, Yunusa Adamu Wada, Sonnie Joshua Oniye and Dalhatu Mukhtari Shehu

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease aff...

Authors: R. Sivaranjani, T. John Zachariah and N. K. Leela

Phytochemical constituent and antimicrobial properties of guava extracts of east Hararghe of Oromia, Ethiopia

There is a need for the screening more effective, affordable and readily available antimicrobial substances from local medicinal plants or herbs as the pathogenic bacteria are developing the resistance to comm...

Authors: Dereje A. Oncho, Meseret C. Ejigu and Olyad E. Urgessa

In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

The majority of epidemic Vibrio cholerae strains have become resistant to multiple antimicrobial agents for many reasons, including mutations, horizontal gene transfers, etc. Therefore, secondary means of treatme...

Authors: Rubaba Karim, Mst Marium Begum, Yeasmin Jui, Tanjina Islam, Masum Billah, Yeasir Arafat, Mehnaz Karim, Ashfia Fatima Khan and Md. Sohanur Rahman

Effects of BNO 1016 on ciliary transport velocity and cell culture surface liquid height of sinonasal epithelial cultures

BNO 1016 is an ethanolic extract of a mixture of five herbs that has been sold in different formulations for decades in the European market and more recently, in the United States market as an over-the-counter...

Authors: Alan D. Workman, Ivy W. Maina, Vasiliki Triantafillou, Neil N. Patel, Charles C. L. Tong, Edward C. Kuan, David W. Kennedy, James N. Palmer, Nithin D. Adappa and Noam A. Cohen

Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review

Plumbago zeylanica L. (Plumbaginaceae) commonly known, as chitrak is pharmacologically important plant. Various studies have been undertaken to assess the pharmacological potential of different parts of the plant...

Authors: Babita Shukla, Sumedha Saxena, Shazia Usmani and Poonam Kushwaha

The protective effect of Rubus fruticosus L. on blood composition in cyclophosphamide treated male rats

Some chemotherapy drugs such cyclophosphamide (CP) has destructive effects on hematopoietic cells in the bone marrow tissue. Due to antioxidant and anti-inflammatory features, medicinal herbs have protective e...

Authors: Naser Mirazi, Ida Shahabi Baher, Zahra Izadi and Abdolkarim Hosseini

Studies on the anthelmintic potentials of the roots of Asparagus racemosus willd. (Asparagaceae)

The Santhal tribe in Assam, India use the roots of Asparagus racemosus (Asparagaceae) as a deworming remedy. The study aimed to investigate the anthelmintic credentials of this plant, using two representative gro...

Authors: Amar Deep Soren and Arun Kumar Yadav

Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

This review aims at establishing the emerging applications of phytobiotics in water treatment and disinfection.

Authors: Adeyemi O. Adeeyo, Joshua N. Edokpayi, Mercy A. Alabi, Titus A. M. Msagati and John O. Odiyo

Cardioprotective effect of Malva verticillata against doxorubicin -induced toxicity in rats

M. verticillata (Malvaceae) is a medicinal plant used in the treatment of wounds, boils, and liver injuries. The plant leaf extracts possess anti-inflammatory and antioxidant activities. Doxorubicin (DOX) is a po...

Authors: Doa’a Anwar Ibrahim, Mohammad Abdualqodous Almutawakel and Rowida Al-Badani

The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study

Herbal medicinal products have a long-standing history of use in the therapy of common respiratory infections. We sought to assess the potential of five validated herbal extracts regarding their ability to res...

Authors: Michela Luisa De Pellegrin, Anette Rohrhofer, Philipp Schuster, Barbara Schmidt, Philipp Peterburs and André Gessner

Bioactive constituents with antibacterial, resistance modulation, anti-biofilm formation and efflux pump inhibition properties from Aidia genipiflora stem bark

Antimicrobial resistance is a global health challenge. The involvement of bacterial biofilms and efflux pumps in the development of multidrug resistance (MDR) is well established. Medicinal plants have been pr...

Authors: Daniel Anokwah, Evelyn Asante-Kwatia, Abraham Y. Mensah, Cynthia Amaning Danquah, Benjamin K. Harley, Isaac Kingsley Amponsah and Lukas Oberer

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

Persea americana (PA) is a popular medicinal plant in folkloric medicines. The present study therefore investigates the ameliorative potentials of its leaves extract on carbon tetrachloride and rifampicin-induced...

Authors: Temidayo Ogunmoyole, Iretiogo Dada and Oluwatosin Adebukola Adebamigbe

Correction to: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, preventive potential and tolerability of BNO 1030 extract, containing Althea root, Chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

An amendment to this paper has been published and can be accessed via the original article.

Authors: Vasyl Popovych, Ivana Koshel, Oleksandr Malofiichuk, Lubov Pyletska, Oleksandr Semenyuk, Oksana Martynnyk and Ruslana Orlovska

Serotonergic and noradrenergic response of ethanol extract; opioidergic response of ethyl acetate extract of Dicranopteris linearis L. leaf

Dicranopteris linearis L. is among the popular tribal plants used for various ailments, although many of its pharmacological potentials have not been investigated yet. The neuropharmacological potentials of the l...

Authors: Mohammad Mustakim Billah, Ayreen Sonia Chowdhury, Kashfia Nawrin, Saqline Mostaq, Md. Abu Rayhan and Razwanur Rahman Tushar

Phytowaste as nutraceuticals in boosting public health

The utilization of bioactive constituent of peels and seeds provide an effective, environment friendly and inexpensive therapy for different forms of human disease, and the production, improvement and document...

Authors: Chinyere S. Dike, Chinna N. Orish, Chukwuemeka R. Nwokocha, Francis D. Sikoki, Bolaji B. Babatunde, Chiara Frazzoli and Orish E. Orisakwe

Proteolytic enzyme arbitrated antagonization of helminthiasis by Cinnamomum cappara leaf extract in Pheretima posthuma

There have been several studies carried out to irradiate Helminthiasis however very little research have been carried out where in the enzymatic activity of plants are exploited to antagonize infections. Here ...

Authors: Kayeen Vadakkan, Meena K Cheruvathur, Anu S Chulliparambil, Famy Francis and Anu P Abimannue

Benefits of Stryphnodendron adstringens when associated with hydrogel on wound healing in diabetic rats

The plant Stryphnodendron adstringens is a species of legume in the genus Stryphnodendron that is found in Brazil. It is also known as “barbatimão-verdadeiro” and it is popularly used in folk medicine due to its ...

Authors: Patricia de Souza de Aguiar, Áurea Pandolfo Correa, Flavia Tasmin Techera Antunes, Alexandre Falcão de Barros Ferraz, Suele Biehals Vencato, Gabriela Jouglard Vasques Amado, Elenir Wiiland, Dione Silva Corrêa, Ivana Grivicich and Alessandra Hubner de Souza

Alpha lipoic acid attenuated neuropathic pain induced by chronic constriction Injury of sciatic nerve in rats

Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and...

Authors: Prasad Neerati and Harika Prathapagiri

Evaluation of antipsoriatic activity of gel containing Pongamia pinnata extract on Imiquimod-induced psoriasis

Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate...

Authors: Kamlesh Wadher, Shital Dabre, Anjali Gaidhane, Sagar Trivedi and Milind Umekar

Sorghum halepense (L.) Pers rhizomes inhibitory potential against diabetes and free radicals

Owing to the side effects of synthetic medicine and less effectiveness against different syndromes, the researchers have focused on phytotherapy to overcome these problems. The purpose of this project was to s...

Authors: Muhammad Abdur Rehman Shah, Rahmat Ali Khan and Mushtaq Ahmed

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Midd...

Authors: Mohamad Hesam Shahrajabian, Wenli Sun and Qi Cheng

Phytodentistry in Africa: prospects for head and neck cancers

Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Al...

Authors: Henry A. Adeola, Saheed Sabiu, Raphael T. Aruleba, Tayo A. Adekiya, Anthonio O. Adefuye, Ogheneochuko J. Adefuye and Babatunji E. Oyinloye

Efficacy, safety and phytochemistry of medicinal plants used for the management of diabetes mellitus in Ethiopia: a systematic review

Despite tremendous developments in synthetic medicine, medicinal plants are still commonly used for the management of diabetes mellitus. This study synthesized scientific evidence on commonly used medicinal pl...

Authors: Serawit Deyno, Kassahun Eneyew, Sisay Seyfe and Elias Wondim

A randomized, open-label, multicentre, comparative study of therapeutic efficacy, preventive potential and tolerability of BNO 1030 extract, containing Althea root, Chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

Acute tonsillitis tends to recur. In cases where patients do not meet the Paradise criteria, the possibilities of non-surgical treatment are more often considered. The objective of this study was to evaluate t...

Authors: Vasyl Popovych, Ivana Koshel, Oleksandr Malofiichuk, Lubov Pyletska, Oleksandr Semenyuk, Oksana Martynnyk and Ruslana Orlovska

Phytochemical screening and anticancer activity of the aerial parts extract of Xanthium strumarium L. on HepG2 cancer cell line

Cancer is one of the most considerable concerns because of increasing the death rate all over the world. Recent studies have disclosed that plant extracts exhibit anticancer activity through various mechanisms. X...

Authors: Hai Trieu Ly, Trieu Minh Truong, Thi Thu Huong Nguyen, Hoang Dung Nguyen, Yuxia Zhao and Van Minh Le

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

The present study was designed to investigate the therapeutic effects against oxidative stress and alleviative effects of Peganum harmala seeds (PH) in rats with Complete Freund’s Adjuvant (CFA) induced arthritis...

Authors: Ashish Singhai and Umesh Kumar Patil

Composition and biological assays of the leaf essential oil of Asparagus flagellaris (Kunth) Bak

Asparagus flagellaris leaves are ethnomedicinally used to treat syphilis, gonorrhea and other sexually transmitted diseases (STDs), with no reports on the volatile constituents. This study was aimed to quantitati...

Authors: Oluwakayode O. Odeja, Michael Gabriel Ibok and Ejike O. Okpala

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the anxiolytic-like effects of Urena lobata L. (MEUL) methanolic extract in...

Authors: Muhammad Torequl Islam, Thoufiqul Alam Riaz, Seyed Abdulmajid Ayatollahi and Javad Sharifi-Rad

Efficacy of an herbal preparation based on lovage, rosemary, and centaury on patients after extracorporal shockwave lithotripsy

To study the effect of a herbal preparation containing a standardised BNO 1040 extract* (based on lovage root, rosemary leaves and aerial parts of centaury) on the extracorporeal shockwave lithotripsy (ESWL) r...

Authors: Volodymyr Frankovych Vitkovskyy

Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide

Authors: Noufissa Touiti, Tarik Sqalli Houssaini and Sanae Achour

Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model

Ziziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular and commonly known as “BAU Kul” in Bangladesh. This study was designed to ...

Authors: Md. Khokon Miah Akanda and A. H. M. Nazmul Hasan

Evaluation of anti-arthritic and anti-inflammatory activities of Martynia annua L. Ethanolic extract

Arthritis is a disorder of change in joint architecture and ligament degeneration. Rheumatoid arthritis is an autoimmune disorder in which body’s immune system targets own cells and degrade them. Martynia annua L...

Authors: Suruj Kaushik, Parag Jain, Trilochan Satapathy, Prerna Purabiya and Amit Roy

Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice

Authors: Valrielyn Saio, Donkupar Syiem, Ramesh Sharma and Careen Liza Pakyntein

Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis

Diabetes is a long-lasting and serious disease that effect in worldwide individual lives, families, and societies. Hyperglycemia of diabetes mellitus produced Advance Glycation End Products that are associated...

Authors: Ayesha Khan, Ajmal Khan, Manzoor Ahmad, Mumtaz Ali, Umar Farooq, Farhan Ahmad Khan and Syed Majid Bukhari

Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative ef...

Authors: Efosa Godwin Ewere, Ngozi Paulinus Okolie, Erhunmwunsee Dalton Avan and Patience Edet Umoh