Articles

Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model

Ziziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular and commonly known as “BAU Kul” in Bangladesh. This study was designed to ...

Authors: Md. Khokon Miah Akanda and A. H. M. Nazmul Hasan

Evaluation of anti-arthritic and anti-inflammatory activities of Martynia annua L. Ethanolic extract

Arthritis is a disorder of change in joint architecture and ligament degeneration. Rheumatoid arthritis is an autoimmune disorder in which body’s immune system targets own cells and degrade them. Martynia annua L...

Authors: Suruj Kaushik, Parag Jain, Trilochan Satapathy, Prerna Purabiya and Amit Roy

Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice

Authors: Valrielyn Saio, Donkupar Syiem, Ramesh Sharma and Careen Liza Pakyntein

Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis

Diabetes is a long-lasting and serious disease that effect in worldwide individual lives, families, and societies. Hyperglycemia of diabetes mellitus produced Advance Glycation End Products that are associated...

Authors: Ayesha Khan, Ajmal Khan, Manzoor Ahmad, Mumtaz Ali, Umar Farooq, Farhan Ahmad Khan and Syed Majid Bukhari

Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration of herbal medicine as alternatives. Also, the increasing rate of the use of herbal antimalarial...

Authors: Earnest Oghenesuvwe Erhirhie, Chidozie Ikegbune, Anthony Ifeanyi Okeke, Chukwunonso Chukwudike Onwuzuligbo, Ngozi Ukamaka Madubuogwu, Uche Maryann Chukwudulue and Onyinye Blessing Okonkwo

Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative ef...

Authors: Efosa Godwin Ewere, Ngozi Paulinus Okolie, Erhunmwunsee Dalton Avan and Patience Edet Umoh

Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. ...

Authors: Emmanuel Sina Akintimehin, Kayode Olayele Karigidi, Tope Samuel Omogunwa and Foluso Olutope Adetuyi

Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Azadirachta indica, Khaya senegalensis, Anogeissus leiocarpus and Tamarindus indica are important ethnomedicinal plants used for health mitigation since the history of mankind. They are used discretionarily in fo...

Authors: Abdullah M. Tauheed, Mohammed Mamman, Abubakar Ahmed, Na’imatu A. Sani, Mohammed M. Suleiman, Mohammed H. Sulaiman and Emmanuel O. Balogun

In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense)

Diabetes mellitus is a metabolic disorder of glucose metabolism and management of blood glucose level is the hallmark in the treatment of this disease. The present study investigated chemical composition, in v...

Authors: L. A. Sulaimon, E. O. Anise, E. M. Obuotor, T. A. Samuel, A. I. Moshood, M. Olajide and T. Fatoke

Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh

Thysanolaena maxima (Roxb.) Kuntze, a perennial grass plant, is usually distributed in hilly regions of the Indian Subcontinent. Different parts of T. maxima have been used as herbal medicine by traditional heale...

Authors: Nazia Hoque, Md. Hossain Sohrab, Farhana Afroz, Satyajit Roy Rony, Suriya Sharmin, Fatema Moni, Choudhury Mahmood Hasan and Md. Sohel Rana

Investigation of the nutritional value and antioxidant activities of common Bangladeshi edible mushrooms

Mushrooms have been recognized both as medicine and nutritional food in many countries for thousands of years, owing to the presence of significant amounts of carbohydrates, proteins, lipids, fibers, and antio...

Authors: Nazifa Sifat, Farhana Lovely, S. M. Neamul Kabir Zihad, Md. Golam Hossain, Jamil A. Shilpi, I. Darren Grice, Mohammad S. Mubarak and Shaikh Jamal Uddin

Lophira lanceolata protects testicular and spermatological damages induced by cisplatin in male Wistar rats

Chemotherapy is associated with male infertility. Cisplatin (CP), an antineoplastic agent has been successfully used for the treatment of diverse kinds of malignancies, however, the use of this effective agent...

Authors: Solomon Tsekohol Agu, Christian Okechukwu Ezihe, Paul Friday Itodo and Hyacinth Adakole Abu

Phytochemical screening and antioxidant, analgesic, and anthelmintic effect of ethanolic extract of Merremia umbellate stems

Merremia umbellata subsp. orientalis (Hallier f.), commonly known as Sapussunda in Bengali, is used in folk medicine for the treatment of different diseases such as helminthiasis, rheumatism, fever, wounds, burns...

Authors: Mst Nazmun Nahar, Amit Kumar Acharzo, Md Sohanur Rahaman, Iffat Ara Zabeen, Shariful Haque and Md Amirul Islam

Evidence-based management of acute rhinosinusitis with herbal products

The overuse of antibiotics for unjustified indications such as the management of acute uncomplicated rhinosinusitis has contributed to the emergence of antibiotic-resistant strains of bacteria and prompted the...

Authors: Claus Bachert

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Trend analysis, graphical representation, and summarization of pharmacological research trends were carried out to act as guidance for the future. The main objectives of the research are to find out the comple...

Authors: Shibam Karmakar, Somnath Paul, Nripendra Madhab Biswas, Jasmina Khanam, Sudip Kumar Kar, Hemanta Mukherjee and Sourav Poddar

In-Vitro antioxidant, anti-lipid peroxidative activities and In-Silico study of Terminalia chebula bioactive compounds

To evaluate the antioxidant activities and to identify the bioactive compounds in hot water extracts of Terminalia chebula fruit.

Authors: Syed Mubashar Sabir, Syed Rizwan Abbas, Shabnam Shahida and Muhammad Faraz Khan

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxico...

Authors: Reshu Tiwari, Mohammed Haris Siddiqui, Tarique Mahmood, Alvina Farooqui, Paramdeep Bagga, Farogh Ahsan and Arshiya Shamim

Correlative study of heavy metal content with biological importance of Solanum virginianum leaf extract

Rapid urbanization and industrialization have greatly impacted the inherent soil composition. Heavy metals disposed in the environment by anthropogenic activities toxicate flora and ultimately affect the phyto...

Authors: Biswash Guragain, Khem Raj Pant, Saugat Bhattarai and Narendra Kumar Chaudhary

Effects of Cnidium monnieri (L.) Cuss. fruit extract on sexual behaviors in male rats

Cnidium monnieri (L.) Cuss. has been used for a long time according to the traditional experiences and documentation in order to treat male sexual disorders. Osthole is one of the main bioactive components in Cni...

Authors: Thuy Duong Dau, Minh Ha Le, Tran Thi Giang Huong Nguyen, Thi Ngoc Mai Dang, Thi Nguyet Que Do and Quynh Trang Tran

Exploration of the role of a lithophytic fern, Pteris vittata L. in wound tissue regeneration and remodelling of genes in hyperglycaemic rat model

In hyperglycemic conditions like diabetes, impaired wound healing occurs due to endothelial damage, dysfunction of leukocyte, decreased phagocytosis and secondary infection which may lead to amputation and deb...

Authors: Tania S. Paul, Biswadeep B. Das, Yogesh P. Talekar and Suchitra Banerjee

Evaluation of in vivo wound healing activity of Moroccan Citrus reticulata peel extract

Citrus reticulata is one of the most cultivated fruit with great benefits for humans in the world. Citrus reticulata peel has several biological activities within them hypoglycemic, hepatoprotective, antimicrobia...

Authors: Sanae Dahmani, Rachida Chabir, Faouzi Errachidi, Wiam Berrada, Hafsa Lansari, Meryem Benidir, Lahsen El Ghadraoui and Abdellatif Bour

Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals

The present study was designed to investigate the in vivo wound healing activity of herbal ointment prepared from Calendula officinalis Linn. on excision wounded rats.

Authors: Shobana Gunasekaran, Agnel Arul John Nayagam and Rameshkannan Natarajan

Evaluation of Andira inermis stem bark extract for hypoglycaemic and antioxidant effects’

The aqueous methanolic extract of Andira inermis(A. inermis) stem bark was screened for phytochemical constituents, antioxidant activity, acute oral toxicity, and preliminary prophylactic normoglycaemic test and ...

Authors: Maxwell Osaronowen Egua, Florence Chimezie Nwinyi, Ode Julius Okwoche, Onakpa Micheal Monday, Akande Motunrayo Ganiyat, Onoja Samuel Okwudili, Mikail Hudu Garba, Akumka David Dezi and Adamu Mohammed

Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach

The practice of ethnomedicine remains to be the primary source of healthcare in many parts of the world, especially among the tribal communities. However, there is a lack of scientific outlook and investigatio...

Authors: Ananta Swargiary and Manita Daimari

Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced d...

Authors: Reyhane Javanshir, Moones Honarmand, Mehran Hosseini and Mina Hemmati

The in vivo toxicity evaluation of leaf and root methanolic extracts of Tephrosia vogelii Hook.f using animal model

Traditionally, herbal medicines are commonly used to cure several diseases since immemorial of human life. Nevertheless, the safety of some traditionally used medicinal plants is uncertain. Since Tephrosia vogeli...

Authors: Stephano Hanolo Mlozi, Juma A. Mmongoyo and Musa Chacha

Phytochemical and pharmacological activities of methanol extract of Artemisia vulgaris L. leaves

Artemisia vulgaris commonly known as “mugwort” is a very important medicinal plant which is used widely for the treatment of various ailments traditionally. The present studies aimed to conduct preliminary phytoc...

Authors: Nurpen Meitei Thangjam, Jasmina Taijong and Awadhesh Kumar

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel e...

Authors: Rosane Soh Matsinkou, Valere Aime Soh Oumbe, Judith Laure Ngondi and Julius Enyong Oben

The phytochemical and pharmacological screening of three crude extracts of Desmodium canum (strong back)

Desmodium canum (Strong Back) is deemed a versatile traditional medicine, where it is used to treat diabetes, hypertension, asthma and erectile dysfunction.

Authors: Ruby Lisa Alexander-Lindo, Roy Barrington Reynolds Porter, Chuckwuemeka Rapheal Nwokocha and Kemmoy Godfrey Lattibeaudiere

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

Obesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forc...

Authors: Kumaraswamy Athesh, Rangaraju Sivasubramanian, Gnanasekaran Jothi and Pemiah Brindha

Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression

Different parts of the medicinal plant Tamarindus indica L. are full of phytochemicals that are able to reduce elevated blood pressure, blood sugar and lipids. These pharmacological effects are due to the presenc...

Authors: Syed Abdul Kuddus, Mazharul Islam Bhuiyan, Nusrat Subhan, Md Hasanuzzaman Shohag, Aura Rahman, Muhammad Maqsud Hossain, Md Ashraful Alam and Ferdous Khan

Cardioprotective effect of garlic extract in isoproterenol-induced myocardial infarction in a rat model: assessment of pro-apoptotic caspase-3 gene expression

Myocardial Infarction (MI), also known as heart attack, is one of the most common cardiovascular diseases. Although certain drugs or mechanical means are used, day by day natural products such as herbs and spi...

Authors: Dipa Islam, Monisha Banerjee Shanta, Samina Akhter, Chadni Lyzu, Mahmuda Hakim, Md. Rezuanul Islam, Liton Chandra Mohanta, Evena Parvin Lipy and Dipankar Chandra Roy

An in vitro screening potential traditional medicinal plants for nephrolithiasis

Today, the attention of researchers has been drawn to the use of medicinal plant for the treatment of kidney stones. The aim of this study was to investigate the effect of five plants used in traditional medic...

Authors: Majid Shirani, Davood Arjaki, Soleiman Kheiri, Elham Bijad, Sareh Mohammadi and Zahra Lorigooini

Effect of hydro-methanol stem bark extract of Burkea africana on erythrocyte osmotic fragility and haematological parameters in acetaminophen-poisoned rats

Burkea africana is a widely used medicinal plant in folkloric medicine in many developing countries of the world. It is useful in the treatment of various ailments including hepatitis, jaundice, diarrhea, stomach...

Authors: Terhemen Festus Swem, Patrick Emeka Aba and Samuel Chukwuneke Udem

Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sa...

Authors: Kazeem Akinyinka Akinwumi, Afusat Jagun Jubril, Oreoluwa Oluwafunke Olaniyan and Yusuf Yusuf Umar

Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene

Renal failure is among the main complications of diabetes disorders and free radical from hyperglycemia is the major cause of this nephrotic complication. This study investigated the therapeutic effects of Bridel...

Authors: Damilola Alex Omoboyowa, Kayode Olayele Karigidi and Temitope Cosmas Aribigbola

Correction to: Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxaninduced diabetic rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Ronia Mostofa, Rayhana Begum, Hongbin Wang, Mst. Marium Begum, Rubaba Karim, Taslima Begum, Nur Alam Siddiquee, Rebeka Sultana, Sonia Sultana, A. K. Lutful Kabir, Sumaiya Alam and Tasnova Tasnim Nova

Triterpene saponins from Barringtonia acutangula (L.) Gaertn as a potent inhibitor of 11β-HSD1 for type 2 diabetes mellitus, obesity, and metabolic syndrome

Barringtonia acutangula (L.) Gaertn, Garcinia indica (Thouars) Choisy, and Feronia limonia (L.) Swingle is widely utilized in traditional folk medicine against diabetes, obesity, and metabolic syndrome but lacks ...

Authors: Vishal Shivalingappa Patil and Nayeem A. Khatib

Stem extract of Albizia richardiana exhibits potent antioxidant, cytotoxic, antimicrobial, anti-inflammatory and thrombolytic effects through in vitro approach

Albizia richardiana belongs Fabaceae family which different parts like fruits, flowers, barks, and roots are used medicinally. The study reports the in vitro anti-inflammatory, thrombolytic, cytotoxicity and anti...

Authors: Mohammad Nazmul Islam, Homyra Tasnim, Laiba Arshad, Md. Areeful Haque, Syed Mohammed Tareq, A. T. M. Mostafa Kamal, Md. Masudur Rahman, A S. M. Ali Reza, Kazi Ashfak Ahmed Chowdhury and Abu Montakim Tareq

Membrane stabilization as a mechanism of the anti-inflammatory activity of ethanolic root extract of Choi (Piper chaba)

This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba roots.

Authors: Samina Yesmin, Arkajyoti Paul, Tarannum Naz, A. B. M. Atiqur Rahman, Sarkar Farhana Akhter, Mir Imam Ibne Wahed, Talha Bin Emran and Shafayet Ahmed Siddiqui

Antidiabetic effect of Wedelia chinensis leaf extract in alloxan induced Swiss albino diabetic mice

Wedelia chinensis (W. chinensis) is a beneficial medicinal herb used in folk medicine to treat many chronic diseases. The present study is aimed to evaluate the antidiabetic property of methanolic extract of W. c...

Authors: Md. Wasim Bari, Md. Monirul Islam, Mahbuba Khatun, Mst Julia Sultana, Rabbi Ahmed, Ariful Islam, Md. Ismail Hossain, Md. Matiar Rahman and Mohammad Amirul Islam

Effects of aqueous extract of fruit pulp of Adansonia digitata L. on the oxidative stress profile against Trypanosoma brucei brucei infection in albino rats

Chemotherapy is the most widely used means of controlling trypanosomosis, however, effectiveness of the drugs available is limited by a number of factors. This study investigates the oxidative stress profile o...

Authors: Oluyomi Olajumoke Ogunleye, Isa Danladi Jatau, Audu Joseph Natala and Shola David Ola-Fadunsin

Characterization of anti-plasmodial, analgesic and anti-inflammatory fraction of Maytenus senegalensis (lam.) Exell leaf extract in mice

The treatment inadequacy and toxicity associated with conventional anti-malarial, anti-inflammatory and analgesic drugs has called for the search of alternatives from medicinal plants, particularly, their phyt...

Authors: Ali A. Jigam, Rachael Musa, Abdulkadir Abdullahi and Bashir Lawal

Anti-diabetic effects of pomegranate extracts in long-term high fructose-fat fed rats

A high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investi...

Authors: Zahra Amri, Mohamed Raâfet Ben Khedher, Mohamed Sghaier Zaibi, Wafa Kharroubi, Mouna Turki, Fatma Ayadi and Mohamed Hammami

Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice

Antioxidants have protective capacity, and can be used combinedly with other substances. Both, ascorbic acid (AA) and phytol (PHY) have many important biological activities, including antioxidant, anti-inflamm...

Authors: Md. Mizanur Rahaman, S. M. Hafiz Hassan, Miquel Martorell, Javad Sharifi-Rad and Muhammad Torequl Islam

Endangered Saudi Arabian plants having ethnobotanical evidence as antidotes for scorpion envenoming

Scorpion sting envenoming in Saudi Arabia posed major public health problems. Conventional treatment with antivenom with its limitations and hazards called for the use of support remediation like prazosin ther...

Authors: Abdulrahman Khazim Al-Asmari, Rajamohamed Abbasmanthiri, Nasreddien Mohammed Abdo Osman and Byan Abdulrahman Al-Asmari

Medicinal plants utilized for hepatic disorders in Ethiopian traditional medical practices: a review

Ethiopia is among the top floral biodiversity rich countries in the world. More than 7000 species of plants, 15% of they are endemic, are reported in the country. Accessibility, cultural enrichment, and cheapn...

Authors: Abrham Belachew Muluye and Muluken Wubetu Ayicheh

Ameliorative effect of Psidium guajava (l.) leaf aqueous extract on aluminium nitrate-induced liver damage in female Wistar rats

Aluminium nitrate and other aluminium-containing compounds have been demonstrated to cause several health challenges. Psidium guajava L) is a well known cultivated tree with hepatoprotective nature and radical sc...

Authors: Aanuoluwapo Adeyimika Afolabi, Ebenezer Adeola Ashamu and Olufemi Idowu Oluranti

Self-emulsifying formulation of Spinacia oleracea reduces the dose and escalates bioavailability of bioactive compounds to accelerate fracture repair in rats

Spinach (Spinacia oleracea) is a rich source of flavonoids and therefore widely used therapeutically as an antioxidant agent in traditional medicine. The present study was undertaken to study the bone regeneratin...

Authors: Ritu Trivedi, Sulekha Adhikary, Priyanka Kothari, Naseer Ahmad, Naresh Mittapelly, Gitu Pandey, Mahendra Shukla, Sudhir Kumar, Kapil Dev, Dharmendra Choudhary, Rakesh Maurya, Jawahar Lal and Prabhat Ranjan Mishra

Inhibitory effects of Mezoneuron benthamianum root extracts on oral cariogenic microorganisms and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging radical

Chewing sticks are commonly used as oral hygiene tool in Africa and reactive oxygen species have been linked to the cause of degenerative diseases because of their ability to induce oxidative damage to biologi...

Authors: Paul M. Osamudiamen, Bolaji B. Oluremi, Fisayo T. Osamudiamen and Olapeju O. Aiyelaagbe