Articles

Impact of Althaea Officinalis extract in patients with atopic eczema: a double-blind randomized controlled trial

Althaea Officinalis introduced as an emerging anti-inflammatory agent with immunomodulatory effects that may suppress the symptoms of atopic eczema. In this study, we aimed to investigate the impact of liposomal ...

Authors: Negar Khalighi, Farahzad Jabbari-Azad, Maral Barzegar-Amini, Jalil Tavakkol-Afshari, Pouran Layegh and Roshanak Salari

A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19

COVID19 is a high burden for medicine and society as still no specific therapy exists. Most patients depend on symptomatic treatment, comparable to the symptomatic treatment in common respiratory infection e.g...

Authors: Vasyl Popovych, Ivana Koshel, Yulia Haman, Vitaly Leschak, Oleksandr Malofiichuk, Natalia Kapustina, Ihor Shevaga, Olha Shevaga and Tetiana Kunytska

Antiproliferative effect of extracts and fractions of the root of Terminalia avicennioides (Combretaceae) Guill and Perr. on HepG2 and Vero cell lines

Terminalia avicennioides Guill and Perr (Combretaceae) is an important West African medicinal plant. The plant is used locally against microbes and parasites in both humans and animals and studies have demonstrat...

Authors: Hadiza Aliyu-Amoo, Hamza Ibrahim Isa, Emmanuel Mfotie Njoya and Lyndy Joy McGaw

Correction to: An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Authors: Reshu Tiwari, Mohammed Haris Siddiqui, Tarique Mahmood, Alvina Farooqui, Paramdeep Bagga, Farogh Ahsan and Arshiya Shamim

Toxicological screening and evaluation of anti-allergic and anti-hyperglycemic potential of Sonneratia caseolaris (L.) Engl. fruits

Sonneratia caseolaris (L.) Engl. (S. caseolaris) belonging to the Sonneratiaceae family is commonly known as Ora. It is traditionally used as an astringent, antiseptic, to treat sprains, swellings, cough and in a...

Authors: Shrabanti Dev, Rabindra Nath Acharyya, Sheuly Akter, Md. Abdullah Al Bari, Kaniz Asma, Hemayet Hossain, Kishore Kumar Sarkar, Nripendra Nath Biswas and Asish Kumar Das

Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India

Cognitive impairment mainly affects learning and problem solving abilities of the person. Traditional medicines, due to fewer side effects, more efficacy and lesser cost are still the choice of treatment in In...

Authors: Sapna Saini, Manjusha Choudhary and Ankur Garg

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

This study was designed to evaluate the protective effects of a Rhamnus alaternus aqueous extract (RAAE) on aluminum chloride-induced hepatotoxicity in rats. A preliminary phytochemical study and antioxidant acti...

Authors: Chahrazed Benzaid, Lazhari Tichati, Fouzia Trea, Mahmoud Rouabhia and Kheireddine Ouali

Toxicological evaluation of the dried hydroethanolic extract of Amaranthus spinosus L. roots in Artemia salina larvae and Sprague Dawley rats

Amaranthus spinosus is a medicinal plant used in traditional medicine to treat several diseases including diabetes and its complications. The aim of this study was to prove the safety of the plant in animal healt...

Authors: Kokou Atchou, Povi Lawson-Evi, Aboudoulatif Diallo and Kwashie Eklu-Gadegbeku

Cardiovascular benefits of Momordica charantia in cholesterol-fed Wistar rats

Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated the beneficial effects of the ethanolic extract of M. charant...

Authors: Silvanus Olu Innih, Ikechi Gerald Eze and Kingsley Omage

Cure and prevention of cardiovascular diseases: herbs for heart

Herbs contribute to more than 60-70% in development of modern medicines in the world market either directly or indirectly. The herbal treatments for congestive heart failure, systolic hypertension, angina, ath...

Authors: Suman Ray and Mahesh Kumar Saini

Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study

Fenugreek (Trigonella foenum-graecum) seed is a popular kitchen spice and medicinal herb with wide applications in Indian folklore. Earlier studies have shown that the hydro-ethanolic extracts of fenugreek are ef...

Authors: Aman Khanna, Jestin Thomas, Febi John, Balu Maliakel and I. M. Krishnakumar

Effect of wound healing in gels containing tinctures of Alnus glutinosa (L) leaves

Alnus glutinosa (L) is a widespread medicinal plant on the territory of the Republic of Belarus. Alnus glutinosa (L) leaves tincture has an anti-inflammatory effect on the diseases of the throat, intestines, in r...

Authors: Volha Mushkina

Preliminary toxicology profile of Dennettia tripetala (Pepper Fruit) methanolic leaves extract

Dennentia tripetalla (Pepper Fruit) belongs to the Annonaceae family and is abundant in Nigeria. Its fruit in folklore medicine is used for treatment of varying ailments. While ample research evidence exists on t...

Authors: Joseph Chukwufumnanya Mordi, Patrick Chukwuyenum Ichipi-Ifukor, Godfery Rume Kweki, Rita Ngozi Ichipi-Ifukor, John Chukwuma Oyem and Uche Dennis-Eboh

Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review

Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Earlier to the innovation of synthetic drugs, human beings completely relied on the plants for the treatment of variou...

Authors: Devanesan Arul Ananth, Garlapati Deviram, Vijayaraghavan Mahalakshmi and V. Ratna Bharathi

Phytotoxicity, cytotoxicity and chemical composition of Spondias mombin Linn. Stem bark

Spondias mombin Linn. is a tropical climate plant with wide applications in ethnomedicinal practice. This study evaluates the phytotoxicity, cytotoxicity and chemical composition of the plant’s stem bark.

Authors: Kissinger Obaogie Orumwensodia, Patrick Ojeifo Uadia and Muhammed Iqbal Choudhary

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammat...

Authors: Luis Ângelo Macedo Santiago, Roberval Nascimento Moraes Neto, Ana Caroline Santos Ataíde, Dâmaris Cristina Sousa Carvalho Fonseca, Enio Fernandes Aragão Soares, Joicy Cortez de Sá Sousa, Renata Mondego-Oliveira, Rachel Melo Ribeiro, Maria do Socorro de Sousa Cartágenes, Lídio Gonçalves Lima-Neto, Rafael Cardoso Carvalho and Eduardo Martins de Sousa

Root extracts of Anacardium occidentale reduce hyperglycemia and oxidative stress in vitro

Hyperglycemia is the hallmark of diabetes, and the associated oxidative stress is a major concern that invites an array of diabetic complications. The traditional practices of medicare are of great, current in...

Authors: TM Archana, K Soumya, Jesna James and Sudheesh Sudhakaran

Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre

Gymnema sylvestre is a reputable medicinal plant commonly explore for the management of diabetes and other ailments in traditional medicine. In the present study, we investigated the phytochemical compositions an...

Authors: Rofiyat Omolara Raji, Hadiza Lami Muhammad, Abdulkadir Abubakar, Sophia Shekwoyan Maikai and Habibat Feyishara Raji

Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characte...

Authors: Olubanke O. Ogunlana, Babatunde O. Adetuyi, Miracle Rotimi, lohor Esalomi, Alaba Adeyemi, Julie Akinyele, Oluseyi E. Ogunlana, Oluwatosin A. Adetuyi, Oluwaseun A. Adebisi, Edward K. Opata, Roua S. Baty and Gaber El-Saber Batiha

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding ...

Authors: Olumide Samuel Fadahunsi, Peter Ifeoluwa Adegbola, Olubukola Sinbad Olorunnisola, Temitayo Idris Subair, David Oluwasegun Adepoju and Ayodeji Zabdiel Abijo

Variation for caffeic acid and phenolic content in different plant parts of Solanum xanthocarpum Schrad. and Wendl. – a commercially important dashmool species

Environmental factors have profound effect on quantity vis-a-vis quality of phytochemicals in medicinal plants. Solanum xanthocarpum Schrad. and Wendl. is among the 10 dashmool species which is utilized in more t...

Authors: Hari Om Saxena, Samiksha Parihar, Naseer Mohammad and Ganesh Pawar

Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review

Black pepper [Piper nigrum (L.), Family: Piperaceae] is used traditionally for the treatment of various diseases including; cough, cold, dyspnea throat diseases, intermittent fever, dysentery, stomachache, worms ...

Authors: Kaliyaperumal Ashokkumar, Muthusamy Murugan, M. K. Dhanya, Arjun Pandian and Thomas D. Warkentin

Anti-proliferative, antioxidant effects of methanol extract of Calotropis procera leaf on lung cancer cells (H1299) and its ameliorative effect on expression of CD146 on blood cells

Calotropis procera leaf is one of the plants commonly utilized in phytomedicine in Nigeria. The present investigation explored the use of the extracts on cell viability and apoptosis respectively. In this study, ...

Authors: Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao, Zhiwei Xu, Quncheng Zhang and Xiaoju Zhang

Diosgenin and galactomannans, natural products in the pharmaceutical sciences

Diosgenin is an isospirostane derivative, which is a steroidal sapogenin and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Galactomannans are heteropolysaccharides composed of...

Authors: Mohamad Hesam Shahrajabian, Wenli Sun, Diorge Jonatas Marmitt and Qi Cheng

Antioxidant property, anti-inflammatory and analgesic effects of aqueous extracts of two onion bulbs varieties (Allium cepa L.)

oxidative stress and inflammation remain the main health problems often linked to degenerative diseases. The aim of this study was to evaluate antioxidant, analgesic and anti-inflammatory properties of onion g...

Authors: Mang Yannick Dimitry, Panyo’o Akdowa Emmanuel, Djiogue Manejo Josiane Edith, Abdou Bouba Armand and Njintang Yanou Nicolas

Protective role of Pandanus tectorius Parkinson ex Du Roi in diabetes, hyperlipidemia, liver and kidney dysfunction in alloxan diabetic rats

Diabetes mellitus (DM), an endocrine disease is characterized by increased level of blood glucose. Diabetes may affect other functions of the body and organs including, renal function and lipid metabolism. Pandan...

Authors: Saima Sundus, Khan Hira, Nida Sohail, Habiba, Amna Tariq, Jehan Ara, Viqar Sultana and Syed Ehteshamul-Haque

Nutritional, antioxidant, angiotensin-converting-enzyme and carbohydrate-hydrolyzing-enzyme inhibitory activities of underutilized leafy vegetable: African wild lettuce (Lactuca taraxacifolia Willd)

African wild lettuce (Lactuca taraxacifolia Willd.) is an underutilised indigenous leafy vegetable containing essential nutrients and medicinal properties. Hence, this study aimed to determine the chemical compos...

Authors: Oluwole Steve Ijarotimi, Ibiyinka Helen Adesanya and Timilehin David Oluwajuyitan

Correction to: Attenuation of glycation and biochemical aberrations in fructose-loaded rats by polyphenol-rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

Authors: Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C. Nkwocha and Ben Chibuzo Amadi

Antimicrobial, antioxidant, anti-inflammatory and cytotoxic study of extracts of Guibourtia tessmanii (harms) J. Léonard from Gabon

Gabonese flora abounds in a significant reserve of plants in medical matter. Thus, medicinal plants occupy a significant place in African pharmacopeia. Aim of this work was to evaluate the antimicrobial, antio...

Authors: Cédric Sima Obiang, Rick Léonid Ngoua Meye Misso, Guy Roger Ndong Atome, Rany Berty Mbeng Obame, Joseph Privat Ondo, Louis Clément Obame Engonga and Edouard Nsi Emvo

Safety assessment of the standardized aqueous extract from solid-state cultured Xylaria nigripes (Wuling Shen) in rats

Xylaria nigripes (Koltz.) Cooke, also known as Wuling Shen, is a high-value medicinal mushroom. It is a herbal medicine traditionally used for treating insomnia, trauma and depression. However, its toxicity has n...

Authors: Ming-Nan Lai, Hui-Chen Hsu and Lean-Teik Ng

Effect of Aegle marmelos on the growth of brushite crystals

The urinary stone formation is a very common health problem due to the prolonged medication. Calcium Hydrogen Phosphate Dihydrate (CaHPO₄.2H₂O, CHPD and Brushite) is one of the major constituent of urinary stone ...

Authors: G. Anushya, R. Mahesh, T. H. Freeda, R. Ramachandran and G. Raju

In vitro antimalarial activity evaluation of two ethnomedicinal plants against chloroquine sensitive and resistant strains of Plasmodium falciparum

In this study, we selected two medicinal plants Citrus maxima (Burm.) Merr. and Artemisia nilagirica (C.B. Clarke) Pamp. on the basis of their traditional use in the treatment of fever associated with malaria in ...

Authors: Neelutpal Gogoi, Bhaskarjyoti Gogoi and Dipak Chetia

Attenuation of glycation and biochemical aberrations in fructose‐loaded rats by polyphenol‐rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

Different parts of the Parkia biglobosa plant are employed in traditional medicine in different African communities. However, information ratifying its use and biochemical influence on health is still scanty in l...

Authors: Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C Nkwocha and Ben Chibuzo Amadi

Hepatoprotective activity against acetaminophen-induced liver dysfunction and GC-MS profiling of a brown algae Sargassum ilicifolium

Drug-induced hepatotoxicity is one of the most important causes of liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug is generally considered safe but its overdose may cause liver tox...

Authors: Khan Hira, Hafiza Farhat, Nida Sohail, Madeeha Ansari, Jehan Ara and Syed Ehteshamul-Haque

Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice

The problem of drug resistance and toxicity in trypanosomiasis is ever-increasing, thereby creating a need to search for efficacious and safer alternatives that are of plant origin. We designed the present stu...

Authors: Nafisa Garba Ayawa, Suleiman Babatunde Ramon-Yusuf, Yunusa Adamu Wada, Sonnie Joshua Oniye and Dalhatu Mukhtari Shehu

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease aff...

Authors: R. Sivaranjani, T. John Zachariah and N. K. Leela

Phytochemical constituent and antimicrobial properties of guava extracts of east Hararghe of Oromia, Ethiopia

There is a need for the screening more effective, affordable and readily available antimicrobial substances from local medicinal plants or herbs as the pathogenic bacteria are developing the resistance to comm...

Authors: Dereje A. Oncho, Meseret C. Ejigu and Olyad E. Urgessa

In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

The majority of epidemic Vibrio cholerae strains have become resistant to multiple antimicrobial agents for many reasons, including mutations, horizontal gene transfers, etc. Therefore, secondary means of treatme...

Authors: Rubaba Karim, Mst Marium Begum, Yeasmin Jui, Tanjina Islam, Masum Billah, Yeasir Arafat, Mehnaz Karim, Ashfia Fatima Khan and Md. Sohanur Rahman

Effects of BNO 1016 on ciliary transport velocity and cell culture surface liquid height of sinonasal epithelial cultures

BNO 1016 is an ethanolic extract of a mixture of five herbs that has been sold in different formulations for decades in the European market and more recently, in the United States market as an over-the-counter...

Authors: Alan D. Workman, Ivy W. Maina, Vasiliki Triantafillou, Neil N. Patel, Charles C. L. Tong, Edward C. Kuan, David W. Kennedy, James N. Palmer, Nithin D. Adappa and Noam A. Cohen

Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review

Plumbago zeylanica L. (Plumbaginaceae) commonly known, as chitrak is pharmacologically important plant. Various studies have been undertaken to assess the pharmacological potential of different parts of the plant...

Authors: Babita Shukla, Sumedha Saxena, Shazia Usmani and Poonam Kushwaha

The protective effect of Rubus fruticosus L. on blood composition in cyclophosphamide treated male rats

Some chemotherapy drugs such cyclophosphamide (CP) has destructive effects on hematopoietic cells in the bone marrow tissue. Due to antioxidant and anti-inflammatory features, medicinal herbs have protective e...

Authors: Naser Mirazi, Ida Shahabi Baher, Zahra Izadi and Abdolkarim Hosseini

Studies on the anthelmintic potentials of the roots of Asparagus racemosus willd. (Asparagaceae)

The Santhal tribe in Assam, India use the roots of Asparagus racemosus (Asparagaceae) as a deworming remedy. The study aimed to investigate the anthelmintic credentials of this plant, using two representative gro...

Authors: Amar Deep Soren and Arun Kumar Yadav

Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

This review aims at establishing the emerging applications of phytobiotics in water treatment and disinfection.

Authors: Adeyemi O. Adeeyo, Joshua N. Edokpayi, Mercy A. Alabi, Titus A. M. Msagati and John O. Odiyo

Cardioprotective effect of Malva verticillata against doxorubicin -induced toxicity in rats

M. verticillata (Malvaceae) is a medicinal plant used in the treatment of wounds, boils, and liver injuries. The plant leaf extracts possess anti-inflammatory and antioxidant activities. Doxorubicin (DOX) is a po...

Authors: Doa’a Anwar Ibrahim, Mohammad Abdualqodous Almutawakel and Rowida Al-Badani

The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study

Herbal medicinal products have a long-standing history of use in the therapy of common respiratory infections. We sought to assess the potential of five validated herbal extracts regarding their ability to res...

Authors: Michela Luisa De Pellegrin, Anette Rohrhofer, Philipp Schuster, Barbara Schmidt, Philipp Peterburs and André Gessner

Bioactive constituents with antibacterial, resistance modulation, anti-biofilm formation and efflux pump inhibition properties from Aidia genipiflora stem bark

Antimicrobial resistance is a global health challenge. The involvement of bacterial biofilms and efflux pumps in the development of multidrug resistance (MDR) is well established. Medicinal plants have been pr...

Authors: Daniel Anokwah, Evelyn Asante-Kwatia, Abraham Y. Mensah, Cynthia Amaning Danquah, Benjamin K. Harley, Isaac Kingsley Amponsah and Lukas Oberer

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

Persea americana (PA) is a popular medicinal plant in folkloric medicines. The present study therefore investigates the ameliorative potentials of its leaves extract on carbon tetrachloride and rifampicin-induced...

Authors: Temidayo Ogunmoyole, Iretiogo Dada and Oluwatosin Adebukola Adebamigbe

Correction to: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, preventive potential and tolerability of BNO 1030 extract, containing Althea root, Chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

An amendment to this paper has been published and can be accessed via the original article.

Authors: Vasyl Popovych, Ivana Koshel, Oleksandr Malofiichuk, Lubov Pyletska, Oleksandr Semenyuk, Oksana Martynnyk and Ruslana Orlovska

Serotonergic and noradrenergic response of ethanol extract; opioidergic response of ethyl acetate extract of Dicranopteris linearis L. leaf

Dicranopteris linearis L. is among the popular tribal plants used for various ailments, although many of its pharmacological potentials have not been investigated yet. The neuropharmacological potentials of the l...

Authors: Mohammad Mustakim Billah, Ayreen Sonia Chowdhury, Kashfia Nawrin, Saqline Mostaq, Md. Abu Rayhan and Razwanur Rahman Tushar

Proteolytic enzyme arbitrated antagonization of helminthiasis by Cinnamomum cappara leaf extract in Pheretima posthuma

There have been several studies carried out to irradiate Helminthiasis however very little research have been carried out where in the enzymatic activity of plants are exploited to antagonize infections. Here ...

Authors: Kayeen Vadakkan, Meena K Cheruvathur, Anu S Chulliparambil, Famy Francis and Anu P Abimannue